{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:42:21Z","timestamp":1790613741298,"version":"4.1.0"},"reference-count":17,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[1988,1,1]]},"DOI":"10.1136\/hrt.59.1.62","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T21:46:00Z","timestamp":1190151960000},"page":"62-68","source":"Crossref","is-referenced-by-count":54,"title":["Infective endocarditis: incidence and mortality in the North East Thames Region."],"prefix":"10.1136","volume":"59","author":[{"given":"J D","family":"Skehan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P G","family":"Mills","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","reference":[{"key":"ref_1","first-page":"289","article-title":"Infective endocarditis with an analysis of 150 cases with special reference to the chronic form of the disease","volume":"2","author":"Horder, T.J.","year":"1909","unstructured":"Horder TJ. Infective endocarditis with an analysis of 150 cases with special reference to the chronic form of the disease. Q J Med 1909;2:289-324.","journal-title":"Q J Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1136\/hrt.50.6.513","article-title":"The microbiology and pathogenesis of infective endocarditis","volume":"50","author":"Bayliss, R.; Clarke, C.; Oakley, C.M.; Somerville, W.; Whitfield, A.G.W.; Young, S.E.J.","year":"1983","unstructured":"Bayliss R, Clarke C, Oakley CM, Somerville W, Whitfield AGW, Young SEJ. The microbiology and pathogenesis of infective endocarditis. Br Heart J 1983;50:513-9.","journal-title":"Br Heart J"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1136\/hrt.51.3.339","article-title":"The bowel, the genitourinary tract, and infective endocarditis","volume":"51","author":"Bayliss, R.; Clarke, C.; Oakley, C.M.; Somerville, W.; Whitfield, A.G.W.; Young, S.E.J.","year":"1984","unstructured":"Bayliss R, Clarke C, Oakley CM, Somerville W, Whitfield AGW, Young SEJ. The bowel, the genitourinary tract, and infective endocarditis. Br Heart J 1984;51:339-45.","journal-title":"Br Heart J"},{"key":"ref_4","first-page":"499","article-title":"Bacterial endocarditis in England in the 1970's. A review of 70 patients","volume":"46","author":"Schnarr, L.P.; Ball, A.P.; Geddes, A.M.; Gray, J.; McChie, D.","year":"1977","unstructured":"Schnarr LP, Ball AP, Geddes AM, Gray J, McChie D. Bacterial endocarditis in England in the 1970's. A review of 70 patients. Q J Med 1977;46:499-512.","journal-title":"Q J Med"},{"key":"ref_5","first-page":"\"315","article-title":"Infective endocarditis, 1970-1979","volume":"49","author":"Moulsdale, M.T.; Egkin, S.J.; Phillips, I.","year":"1980","unstructured":"Moulsdale MT, Egkin SJ, Phillips I. Infective endocarditis, 1970-1979. Q J Med 1980;49:315-28. (for example, uncontrolled infection, sudden death, 9 Bayliss R, Clark C, Oakley CM, Somerville W, stroke) do not necessarily respond so well to the use Whitfield AGW, Young SEJ. Incidence, mortality of antibiotic chemotherapy or other medical interand prevention of infective endocarditis. J R Coll ventions. After analysing the case records of the patients who died we believe that most deaths were unavoidable, mainly because serious complications were already established at the time of admission to hospital. It is clear that many of the complications of endocarditis are unresponsive to treatment and Physicians (Lond) 1986;20:15-20.","journal-title":"Q J Med; stroke) do not necessarily respond so well to the use Whitfield AGW, Young SEJ. Incidence, mortality of antibiotic chemotherapy or other medical interand prevention of infective endocarditis"},{"key":"ref_6","article-title":"Population and Census Surveys","author":"of, Office","year":"1984","unstructured":"Office of Population and Census Surveys. Monitor. PPI 84\/4. June 1984.","journal-title":"Monitor. PPI"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0140-6736(83)91713-0","article-title":"High dose oral erythromycin for preventing endocarditis","volume":"i:","author":"Shanson, D.C.; McNabb, W.R.; Ruby, K.","year":"1983","unstructured":"Shanson DC, McNabb WR, Ruby K. High dose oral erythromycin for preventing endocarditis [Letter]. Lancet 1983;i:299-300.","journal-title":"Lancet"},{"key":"ref_8","article-title":"Adult dental health. It is likely that endocarditis will continue to be a United Kingdom","volume-title":"Office of Population major clinical challenge mainly because of the unknown aetiological factors in nearly half the cases, the number of individuals presenting who were not previously known to have cardiac abnormalities, and increasing numbers of patients with prosthetic valves. A reduction of incidence might occur with and Census Surveys","volume":"2","author":"Todd, J.E.; Walker, A.M.; Dodd, P.","year":"1978","unstructured":"Todd JE, Walker AM, Dodd P. Adult dental health. It is likely that endocarditis will continue to be a United Kingdom 1978. Vol. 2. Office of Population major clinical challenge mainly because of the unknown aetiological factors in nearly half the cases, the number of individuals presenting who were not previously known to have cardiac abnormalities, and increasing numbers of patients with prosthetic valves. A reduction of incidence might occur with and Census Surveys. London: HMSO, 1982."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1136\/hrt.54.2.115","article-title":"The challenge and the reproach of infective endocarditis","volume":"54","author":"Goodwin, J.F.","year":"1985","unstructured":"Goodwin JF. The challenge and the reproach of infective endocarditis. Br Heart J 1985;54:115-8.","journal-title":"Br Heart J"},{"key":"ref_10","first-page":"1323","article-title":"Working Party of the British Society for Antimicrobal Chemotherapy. Antibiotic prophylaxis of infective improvements in the use of antibiotic prophylaxis or endocarditis","volume":"ii:","year":"1982","unstructured":"Working Party of the British Society for Antimicrobal Chemotherapy. Antibiotic prophylaxis of infective improvements in the use of antibiotic prophylaxis or endocarditis. Lancet 1982;ii:1323-6.","journal-title":"Lancet"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1136\/bmj.289.6457.1499","article-title":"Failure of single dose amoxycillin as prophylaxis against endocarditis","volume":"289","author":"Denning, D.W.; Cassidy, M.; Dougall, A.; Hills, W.S.","year":"1984","unstructured":"Denning DW, Cassidy M, Dougall A, Hills WS. Failure of single dose amoxycillin as prophylaxis against endocarditis. Br Med J 1984;289:1499-500.","journal-title":"Br Med J"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1093\/jac\/14.4.379","article-title":"Chemoprophylaxis for bacterial endocarditis-a survey of current practise in London","volume":"14","author":"Gould, I.","year":"1984","unstructured":"Gould I. Chemoprophylaxis for bacterial endocarditis-a survey of current practise in London. J Antimicrob Chemother 1984;14:379-94.","journal-title":"J Antimicrob Chemother"},{"key":"ref_13","first-page":"53","article-title":"The role of echocardiography in suspected bacterial endocarditis","volume":"C):","author":"Donaldson, R.M.; Westgate, C.; Bennett, J.G.; Rickards, A.F.","year":"1984","unstructured":"Donaldson RM, Westgate C, Bennett JG, Rickards AF. The role of echocardiography in suspected bacterial endocarditis. Eur Heart J 1984;5(suppl C): 53-7.","journal-title":"Eur Heart J"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1136\/hrt.53.3.310","article-title":"Vegetations in infective endocarditis: clinical relevance and diagnosis by cross sectional echocardiography","volume":"53","author":"Stafford, W.S.; Petch, J.; Radford, D.J.","year":"1985","unstructured":"Stafford WS, Petch J, Radford DJ. Vegetations in infective endocarditis: clinical relevance and diagnosis by cross sectional echocardiography. Br Heart J 1985;53:310-3.","journal-title":"Br Heart J"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0002-9343(71)90326-3","article-title":"Infective endocarditis at the Presbyterian Hospital in New York City from 1938-67","volume":"51","author":"Cherubin, C.E.; Nen, H.C.","year":"1971","unstructured":"Cherubin CE, Nen HC. Infective endocarditis at the Presbyterian Hospital in New York City from 1938-67. Am J Med 1971;51:83-96.","journal-title":"Am J Med"},{"key":"ref_16","first-page":"232","volume":"24","author":"endocarditis, Oakley C.M.Infective","year":"1980","unstructured":"Oakley CM. Infective endocarditis. Br J Hosp Med 1980;24:232-43.","journal-title":"Br J Hosp Med"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1136\/bmj.287.6388.320","article-title":"Surgical treatment of infective endocarditis with special reference to prosthetic valve infection","volume":"287","author":"Westaby, S.; Oakley, C.; Sapsford, R.N.; Bentall, H.H.","year":"1983","unstructured":"Westaby S, Oakley C, Sapsford RN, Bentall HH. Surgical treatment of infective endocarditis with special reference to prosthetic valve infection. Br Med J 1983;287:320-3.","journal-title":"Br Med J"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/hrt.59.1.62","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T01:03:04Z","timestamp":1601082184000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/hrt.59.1.62"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,1,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1988,1,1]]}},"URL":"https:\/\/doi.org\/10.1136\/hrt.59.1.62","relation":{},"ISSN":["1355-6037"],"issn-type":[{"value":"1355-6037","type":"print"}],"subject":[],"published":{"date-parts":[[1988,1,1]]}}}