{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T11:10:19Z","timestamp":1764587419733},"reference-count":30,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[1988,11,1]]},"DOI":"10.1136\/hrt.60.5.455","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T21:46:00Z","timestamp":1190151960000},"page":"455-458","source":"Crossref","is-referenced-by-count":35,"title":["Intracardiac thrombosis, phospholipid antibodies, and two-chambered right ventricle."],"prefix":"10.1136","volume":"60","author":[{"given":"M A","family":"Coppock","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R E","family":"Safford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G K","family":"Danielson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","reference":[{"key":"ref_1","first-page":"738","article-title":"Boyle In 1924, Libman and Sacks reported valvar and","volume-title":"Measurement of anti-cardiolipin mural endocarditis associated with systemic lupus erythematosus.'9 Since their initial report, systemic lupus erythematosus has been shown to have protean cardiovascular manifestations.21 These have included pancarditis with pericardial thickening and antibodies by an enzyme-linked immunosorbent assay (ELISA): standardization and quantitation of results. Clin Exp Immunol 1985; 62","author":"Loizou, S.; McCrea, J.D.; Rudge, A.C.; Reynolds, R.","unstructured":"Loizou S, McCrea JD, Rudge AC, Reynolds R, Boyle In 1924, Libman and Sacks reported valvar and CC, Harris EN. Measurement of anti-cardiolipin mural endocarditis associated with systemic lupus erythematosus.'9 Since their initial report, systemic lupus erythematosus has been shown to have protean cardiovascular manifestations.21 These have included pancarditis with pericardial thickening and antibodies by an enzyme-linked immunosorbent assay (ELISA): standardization and quantitation of results. Clin Exp Immunol 1985;62:738-45."},{"key":"ref_2","first-page":"1271","article-title":"revised criteria for the classification of systemic lupus erythematosus","volume":"25","author":"Tan, E.M.; Cohen, A.S.; Fries, J.F.","year":"1982","unstructured":"Tan EM, Cohen AS, Fries JF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982;25:1271-7.","journal-title":"The"},{"key":"ref_3","series-title":"Clin carditis, valvar thickening, aortic insufficiency, mitral regurgitation, and infective endocarditis. Echocardiographic findings have included pericardial thickening, thickened aortic and mitral valves, and calcification of the mitral annulus.' To our knowledge, an intracardiac mass in a patient with a Invest 1952; 31","first-page":"621","article-title":"coronary artery disease with myocardial 3 Conley CL, Hartmann RC. A hemorrhagic disorder infarction, and, rarely, coronary arteritis. Reported caused by circulating anticoagulant in patients with valvar lesions have included Libman-Sacks endodisseminated lupus erythematosus","author":"effusion","unstructured":"effusion, coronary artery disease with myocardial 3 Conley CL, Hartmann RC. A hemorrhagic disorder infarction, and, rarely, coronary arteritis. Reported caused by circulating anticoagulant in patients with valvar lesions have included Libman-Sacks endodisseminated lupus erythematosus [Abstract]. J Clin carditis, valvar thickening, aortic insufficiency, mitral regurgitation, and infective endocarditis. Echocardiographic findings have included pericardial thickening, thickened aortic and mitral valves, and calcification of the mitral annulus.' To our knowledge, an intracardiac mass in a patient with a Invest 1952;31:621-2."},{"key":"ref_4","first-page":"416","article-title":"Thrombosis in systemic lupus erythematosus despite circulating anticoagulants","volume":"62","author":"Bowie, E.J.W.; JH, Jr, Thompson; Pascuzzi, C.A.; CA, Jr, Owen","year":"1963","unstructured":"Bowie EJW, Thompson JH Jr, Pascuzzi CA, Owen CA Jr. Thrombosis in systemic lupus erythematosus despite circulating anticoagulants. J Lab Clin Med 1963;62:416-30.","journal-title":"J Lab Clin Med"},{"key":"ref_5","article-title":"Acquired inhibitors of blood coagulation. Prog Hemost Thromb 1972; 1: lupus-like illness, lupus anticoagulant activity, and 75-95. cardiolipin antibodies has not been reported before","author":"Feinstein, D.I.; Rapaport, S.I.","unstructured":"Feinstein DI, Rapaport SI. Acquired inhibitors of blood coagulation. Prog Hemost Thromb 1972;1: lupus-like illness, lupus anticoagulant activity, and 75-95. cardiolipin antibodies has not been reported before."},{"key":"ref_6","first-page":"265","article-title":"219 cases","volume":"19","author":"laboratory features of","year":"1985","unstructured":"laboratory features of 219 cases. Am J Hematol 1985;19:265-75.","journal-title":"Am J Hematol"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"156","DOI":"10.7326\/0003-4819-92-2-156","article-title":"Thrombosis in patients with the lupus anticoagulant","volume":"92","author":"Mueh, JR, Herbst; KD, Rapaport; S.I.","year":"1980","unstructured":"Mueh JR, Herbst KD, Rapaport SI. Thrombosis in patients with the lupus anticoagulant. Ann Intern Med 1980;92:156-9.","journal-title":"Ann Intern Med"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1056\/NEJM198511213132104","article-title":"Obstetric complications associated with the lupus chemical correlates of lupus anticoagulant activity anticoagulant","volume":"313","year":"1985","unstructured":"Obstetric complications associated with the lupus chemical correlates of lupus anticoagulant activity anticoagulant. N Engl J Med 1985;313:1322-6.","journal-title":"N Engl J Med"},{"key":"ref_9","first-page":"3278","article-title":"and phospholipid antibodies were found","volume":"253","author":"N, Friberg J.","year":"1985","unstructured":"and phospholipid antibodies were found in our 9 Gleicher N, Friberg J. IgM gammopathy and the lupus patient, ingluding prolonged phospholipid-dependent coagulation, inability to restore normal prothrombin time and activated partial thromboplastin time during mixing studies, a positive platelet neutralisation test, and raised titres to cardiolipin anticoagulant syndrome in habitual aborters. JAMA 1985;253:3278-81.","journal-title":"JAMA; IgM gammopathy and the lupus patient, ingluding prolonged phospholipid-dependent coagulation, inability to restore normal prothrombin time and activated partial thromboplastin time during mixing studies, a positive platelet neutralisation test, and raised titres to cardiolipin anticoagulant syndrome in habitual aborters"},{"key":"ref_10","first-page":"398","article-title":"The lupusanticoagulant: clinical and obstetric implications","volume":"97","author":"Lubbe, W.F.; Butler, W.S.; Liggins, G.C.","year":"1984","unstructured":"Lubbe WF, Butler WS, Liggins GC. The lupusanticoagulant: clinical and obstetric implications. NZ Med J 1984;97:398-402.","journal-title":"NZ Med J"},{"key":"ref_11","article-title":"Thrombosis in systemic We speculate that an abnormal flow pattern in the lupus erythematosus: striking association with the right ventricle (caused by the anomalous muscle presence of circulating lupus anticoagulant","author":"Loizou, S.; Hughes, G.R.V.","unstructured":"Loizou S, Hughes GRV. Thrombosis in systemic We speculate that an abnormal flow pattern in the lupus erythematosus: striking association with the right ventricle (caused by the anomalous muscle presence of circulating lupus anticoagulant. Br Med J","journal-title":"Br Med J"},{"key":"ref_12","first-page":"1021","article-title":"bundles), associated with a tendency to thrombosis because of the cardiolipin antibodies, led to the formation of the intracardiac mass in our patient. Six months after operation the patient was symptom free. Although there are no data on the efficacy of long term anticoagulation in preventing recurrent thrombosis in this setting, the reports by 1983; 287","unstructured":"bundles), associated with a tendency to thrombosis because of the cardiolipin antibodies, led to the formation of the intracardiac mass in our patient. Six months after operation the patient was symptom free. Although there are no data on the efficacy of long term anticoagulation in preventing recurrent thrombosis in this setting, the reports by 1983;287:1021-3."},{"key":"ref_13","first-page":"349","article-title":"Lupus anticoagulant: revival of an old phenomenon. Clin Exp Rheumatol","volume":"3","author":"Derksen, R.H.W.M.; Kater, L.","year":"1985","unstructured":"Derksen RHWM, Kater L. Lupus anticoagulant: revival of an old phenomenon. Clin Exp Rheumatol 1985;3:349-57."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1056\/NEJM198507183130304","article-title":"Antibody to cardiolipin as a predictor of fetal distress or death in pregnant patients with systemic lupus erythematosus","volume":"313","author":"Lockshin, M.D.; Druzin, M.L.; Goel, S.","year":"1985","unstructured":"Lockshin MD, Druzin ML, Goel S, et al. Antibody to cardiolipin as a predictor of fetal distress or death in pregnant patients with systemic lupus erythematosus. N Engl J Med 1985;313:152-6.","journal-title":"N Engl J Med"},{"key":"ref_15","first-page":"1211","article-title":"Hughes\"","volume":"ii:","author":"al 6; EN, Gharavi A.E.; ML, Boey","year":"1983","unstructured":"Hughes\" and Gastineau et al 6 suggest that oral 14 Harris EN, Gharavi AE, Boey ML, et al. Anticaranticoagulation may be protective. In addition, Asherson et al have reported that warfarin withdrawal is associated with a high incidence of diolipin antibodies: detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus. Lancet 1983;ii:1211-4.","journal-title":"and Gastineau et; Anticaranticoagulation may be protective. In addition, Asherson et al have reported that warfarin withdrawal is associated with a high incidence of diolipin antibodies: detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus"},{"key":"ref_16","first-page":"285","article-title":"The anticardiolipin syndrome. Clin Exp Rheumatol","volume":"3","author":"Hughes, G.R.V.","year":"1985","unstructured":"Hughes GRV. The anticardiolipin syndrome. Clin Exp Rheumatol 1985;3:285-6."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1136\/bmj.287.6399.1088","article-title":"Thrombosis, abortion, cerebral disease, and the lupus anticoagulant","volume":"287","author":"Hughes, G.R.V.","year":"1983","unstructured":"Hughes GRV. Thrombosis, abortion, cerebral disease, and the lupus anticoagulant. Br Med J 1983; 287:1088-9.","journal-title":"Br Med J"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1136\/ard.44.12.823","article-title":"Anticardiolipin antibody, recurrent thrombosis, and warfarin withdrawal","volume":"44","author":"Asherson, R.A.; Chan, J.K.H.; Harris, E.N.; Gharavi, A.E.; Hughes, G.R.V.","year":"1985","unstructured":"Asherson RA, Chan JKH, Harris EN, Gharavi AE, Hughes GRV. Anticardiolipin antibody, recurrent thrombosis, and warfarin withdrawal. Ann Rheum Dis 1985;44:823-5.","journal-title":"Ann Rheum Dis"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1001\/archinte.1986.00360230069012","article-title":"Thrombosis, recurrent fetal loss, and thrombocytopenia: predictive value of the anticardiolipin antibody test","volume":"146","author":"Harris, E.N.; Chan, J.K.H.; Asherson, R.A.; Aber, V.R.; Gharavi, A.E.; Hughes, G.R.V.","year":"1986","unstructured":"Harris EN, Chan JKH, Asherson RA, Aber VR, Gharavi AE, Hughes GRV. Thrombosis, recurrent fetal loss, and thrombocytopenia: predictive value of the anticardiolipin antibody test. Arch Intern Med 1986;146:2153-6.","journal-title":"Arch Intern Med"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1001\/archinte.1924.00110300044002","article-title":"A hitherto undescribed form of valvular and mural endocarditis","volume":"33","author":"Libman, E.; Sacks, B.","year":"1924","unstructured":"Libman E, Sacks B. A hitherto undescribed form of valvular and mural endocarditis. Arch Intern Med 1924;33:701-37.","journal-title":"Arch Intern Med"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0307-742X(21)00207-1","article-title":"Cardiac manifestations of SLE","volume":"8","author":"Chang, R.W.","year":"1982","unstructured":"Chang RW. Cardiac manifestations of SLE. Clin Rheum Dis 1982;8:197-206.","journal-title":"Clin Rheum Dis"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/0002-8703(85)90023-7","article-title":"Cardiovascular manifestations of systemic lupus erythematosus","volume":"110","author":"Doherty, N.E.; Siegel, R.J.","year":"1985","unstructured":"Doherty NE, Siegel RJ. Cardiovascular manifestations of systemic lupus erythematosus. Am Heart J 1985;110: 1257-65.","journal-title":"Am Heart J"},{"key":"ref_23","unstructured":"British Cardiac Society"},{"key":"ref_24","article-title":"The Autumn Meeting will be held at the Wembley Conference Centre, London, on 22 to 24 November 1988. The closing date for receipt of abstracts was","unstructured":"The Autumn Meeting will be held at the Wembley Conference Centre, London, on 22 to 24 November 1988. The closing date for receipt of abstracts was"},{"key":"ref_25","article-title":"The Annual General Meeting for 1989 will take place in Oxford","volume-title":"and the closing date for receipt of abstracts will be","author":"1988, June","year":"1989","unstructured":"June 1988. The Annual General Meeting for 1989 will take place in Oxford on 6 and 7 April 1989, and the closing date for receipt of abstracts will be 6 January 1989."},{"key":"ref_26","article-title":"A meeting on Electrocardiography: Past and Future will be held","volume-title":"For further information contact the Conference Department, The New York Academy of Sciences, 2 East 63rd","year":"1989","unstructured":"A meeting on Electrocardiography: Past and Future will be held in Nice on 7 to 9 September 1989. For further information contact the Conference Department, The New York Academy of Sciences, 2 East 63rd Street, New York, NY 10021, USA."},{"key":"ref_27","article-title":"The 2nd International Conference on Preventive Cardiology (sponsored by the Council on Epidemiology, American Heart Association) will take place in","volume-title":"For details write to Secretariat, 9650 Rockville Pike","author":"Bethesda,","year":"1989","unstructured":"The 2nd International Conference on Preventive Cardiology (sponsored by the Council on Epidemiology, American Heart Association) will take place in Washington, DC, on 18 to 22 June 1989. For details write to Secretariat, 9650 Rockville Pike, Bethesda, Maryland 20814, USA."},{"key":"ref_28","article-title":"Atrial arrhythmias An international symposium on Current Concepts in the Study and Management of Atrial Arrhythmias will be held in Lyon","volume-title":"For further information write to Professor P Touboul, Hopital Cardiovasculaire et Pneumologique Louis Pradel, BP Lyon Montchat, 69394 Lyon Cedex 3, France","year":"1989","unstructured":"Atrial arrhythmias An international symposium on Current Concepts in the Study and Management of Atrial Arrhythmias will be held in Lyon on 6 to 8 December 1989. For further information write to Professor P Touboul, Hopital Cardiovasculaire et Pneumologique Louis Pradel, BP Lyon Montchat, 69394 Lyon Cedex 3, France."},{"key":"ref_29","article-title":"The 16th World Congress on Diseases of the Chest will be held at the Sheraton-Boston Hotel and Towers and the John B Hynes Convention Auditorium on 30 October to 3 November 1989. Information from Division of","volume":"911","unstructured":"The 16th World Congress on Diseases of the Chest will be held at the Sheraton-Boston Hotel and Towers and the John B Hynes Convention Auditorium on 30 October to 3 November 1989. Information from Division of Education, American College of Chest Physicians, 911 Busse Highway, Park Ridge, IL 60068-2375, USA.","journal-title":"Education, American College of Chest Physicians; Busse Highway, Park"},{"key":"ref_30","first-page":"\"6NN\" # \"5773).\"","article-title":"British Nuclear Cardiology Group The annual meeting of the British Nuclear Cardiology Group will be held at the Robin Brook Centre, St Bartholomew's Hospital, West Smithfield, London EClA 7BE on 21 November 1988. For further details contact Dr Richard Underwood, MR Unit, National Heart and Chest Hospitals, 30 Britten Street","volume":"3","author":"(01-351","unstructured":"British Nuclear Cardiology Group The annual meeting of the British Nuclear Cardiology Group will be held at the Robin Brook Centre, St Bartholomew's Hospital, West Smithfield, London EClA 7BE on 21 November 1988. For further details contact Dr Richard Underwood, MR Unit, National Heart and Chest Hospitals, 30 Britten Street, London SW3 6NN (01-351 5773).","journal-title":"London"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/hrt.60.5.455","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T19:45:20Z","timestamp":1629747920000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/hrt.60.5.455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,11,1]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1988,11,1]]}},"URL":"https:\/\/doi.org\/10.1136\/hrt.60.5.455","relation":{},"ISSN":["1355-6037"],"issn-type":[{"value":"1355-6037","type":"print"}],"subject":[],"published":{"date-parts":[[1988,11,1]]}}}