{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:16:48Z","timestamp":1761823008784},"reference-count":35,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[1991,4,1]]},"DOI":"10.1136\/hrt.65.4.184","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T21:46:00Z","timestamp":1190151960000},"page":"184-187","source":"Crossref","is-referenced-by-count":7,"title":["Platelet aggregating activity in serum from patients with HLA-B27 associated rheumatic and cardiac disorders: a possible link to the proliferative vascular changes."],"prefix":"10.1136","volume":"65","author":[{"given":"L","family":"Bergfeldt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Edhag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Holm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Norberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1001\/archinte.1966.03870120064013","article-title":"Heart block in ankylosing spondylitis","volume":"117","author":"Weed, C.L.; Kulander, B.G.; Mazzarella, J.A.; Decker, J.L.","year":"1966","unstructured":"Weed CL, Kulander BG, Mazzarella JA, Decker JL. Heart block in ankylosing spondylitis. Arch Intern Med 1966;117:800-6.","journal-title":"Arch Intern Med"},{"key":"ref_2","first-page":"1309","article-title":"Cardiovascular manifestations ofankylosing spondylitis","volume":"111","author":"Kinsella, T.D.; Johnson, L.G.; Sutherland, R.I.","year":"1974","unstructured":"Kinsella TD, Johnson LG, Sutherland RI. Cardiovascular manifestations ofankylosing spondylitis. Can Med Assoc J 1974;111:1309-1 1.","journal-title":"Can Med Assoc J"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/0002-9343(83)91193-2","article-title":"HLA B27-associated rheumatic diseases with severe cardiac bradyarrhythmias. Clinical features and prevalence in 223 men with permanent pacemakers","volume":"75","author":"Bergfeldt, L.","year":"1983","unstructured":"Bergfeldt L. HLA B27-associated rheumatic diseases with severe cardiac bradyarrhythmias. Clinical features and prevalence in 223 men with permanent pacemakers. Am J Med 1983;75:210-5.","journal-title":"Am J Med"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/0002-9343(72)90142-8","article-title":"Aortic insufficiency in five patients with Reiter's syndrome. A detailed clinical and pathologic study","volume":"53","author":"Paulus, H.E.; Pearson, P.M.; W, Jr, Pitts","year":"1972","unstructured":"Paulus HE, Pearson PM, Pitts W Jr. Aortic insufficiency in five patients with Reiter's syndrome. A detailed clinical and pathologic study. Am J Med 1972;53:464-72.","journal-title":"Am J Med"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1161\/01.CIR.48.5.1014","article-title":"Ankylosing spondylitis and aortic regurgitation. Description ofthe characteristic lesion from study of eight necropsy patients","volume":"48","author":"Bulkley, B.H.; Roberts, W.C.","year":"1973","unstructured":"Bulkley BH, Roberts WC. Ankylosing spondylitis and aortic regurgitation. Description ofthe characteristic lesion from study of eight necropsy patients. Circulation 1973; 48:1014-27.","journal-title":"Circulation"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0002-9343(74)90602-0","article-title":"Combined mitral and aortic regurgitation in ankylosing spondylitis. Angiographic and anatomic features","volume":"56","author":"Roberts, W.C.; Hollingsworth, J.F.; Bulkley, B.H.; Jaffe, R.R.; Epstein, S.E.; Stinson, E.B.","year":"1974","unstructured":"Roberts WC, Hollingsworth JF, Bulkley BH, Jaffe RR, Epstein SE, Stinson EB. Combined mitral and aortic regurgitation in ankylosing spondylitis. Angiographic and anatomic features. Am J Med 1974;56:237-43.","journal-title":"Am J Med"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/0002-9343(84)90552-7","article-title":"HLA-B27-associated heart disease. Clinico-pathologic study ofthree cases","volume":"77","year":"1984","unstructured":"Bergfeldt L, Edhag 0, Rajs J. HLA-B27-associated heart disease. Clinico-pathologic study ofthree cases. Am J Med 1984;77:961-7.","journal-title":"Am J Med"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1093\/oxfordjournals.eurheartj.a061676","article-title":"Left ventricular function in patients with ankylosing spondylitis and Reiter's disease","volume":"5","author":"Ribeiro, P.; Morley, K.D.; Shapiro, L.M.; Garnett, R.A.F.; Hughes, G.R.V.; Goodwin, J.F.","year":"1984","unstructured":"Ribeiro P, Morley KD, Shapiro LM, Garnett RAF, Hughes GRV, Goodwin JF. Left ventricular function in patients with ankylosing spondylitis and Reiter's disease. Eur Heart J 1984;5:419-22.","journal-title":"Eur Heart J"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/S0140-6736(87)92268-9","article-title":"The myocardium in ankylosing spondylitis. A clinical, echocardiographic, and histopathological study","volume":"i:","author":"Brewerton, D.A.; Goddard, D.H.; Moore, R.B.","year":"1987","unstructured":"Brewerton DA, Goddard DH, Moore RB, et al. The myocardium in ankylosing spondylitis. A clinical, echocardiographic, and histopathological study. Lancet 1987;i:995-8.","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0002-9343(82)90177-2","article-title":"Ankylosing spondylitis: an important cause of severe disturbances of the cardiac conduction system. Prevalence among 223 pacemaker-treated men","volume":"73","year":"1982","unstructured":"Bergfeldt L, Edhag 0, Vedin L, Vallin H. Ankylosing spondylitis: an important cause of severe disturbances of the cardiac conduction system. Prevalence among 223 pacemaker-treated men. Am J Med 1982;73:187-91.","journal-title":"Am J Med"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1399-0039.1983.tb00188.x","article-title":"Complete heart block-another HLA B27 associated disease manifestation","volume":"21","author":"Bergfeldt, L.; Moller, E.","year":"1983","unstructured":"Bergfeldt L, Moller E. Complete heart block-another HLA B27 associated disease manifestation. Tissue Antigens 1983;21:385-90.","journal-title":"Tissue Antigens"},{"key":"ref_12","first-page":"941","article-title":"Pacemaker treated women with heart block have no increase in the frequency of HLA-B27 and associated rheumatic disorders in contrast to men-a sex linked difference in disease susceptibility","volume":"13","author":"Bergfeldt, L.; Moller, E.","year":"1986","unstructured":"Bergfeldt L, Moller E. Pacemaker treated women with heart block have no increase in the frequency of HLA-B27 and associated rheumatic disorders in contrast to men-a sex linked difference in disease susceptibility. J Rheumatol 1986;13:941-3.","journal-title":"J Rheumatol"},{"key":"ref_13","first-page":"757","article-title":"HLA antigens in isolated aortic incompetence","volume":"7","author":"Tan, P.L.J.; Butler, M.J.; Woodfield, D.G.; Jacobson, C.; Grigor, R.R.; Caughey, D.E.","year":"1980","unstructured":"Tan PLJ, Butler MJ, Woodfield DG, Jacobson C, Grigor RR, Caughey DE. HLA antigens in isolated aortic incompetence [Letter]. J Rheumatol 1980;7:757-9.","journal-title":"J Rheumatol"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1001\/archinte.1985.00360050066010","article-title":"Seronegative spondyloarthropathies in lone aortic insufficiency","volume":"145","author":"Qaiyumi, S.; Ul Hassan, Z.; Toone, E.","year":"1985","unstructured":"Qaiyumi S, Ul Hassan Z, Toone E. Seronegative spondyloarthropathies in lone aortic insufficiency. Arch Intern Med 1985;145:822-4.","journal-title":"Arch Intern Med"},{"key":"ref_15","first-page":"12","article-title":"Edhag 0. HLA-B27: an important genetic risk factor for lone aortic regurgitation and severe conduction system abnormalities","volume":"85","author":"Bergfeldt, L.; Insulander, P.; Lindblom, D.; Moller, E.","year":"1988","unstructured":"Bergfeldt L, Insulander P, Lindblom D, Moller E, Edhag 0. HLA-B27: an important genetic risk factor for lone aortic regurgitation and severe conduction system abnormalities. Am JMed 1988;85:12-8.","journal-title":"Am JMed"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1136\/ard.13.3.219","article-title":"Histological studies of pelvospondylitis ossificans (ankylosing spondylitis) correlated with clinical and radiological findings","volume":"13","author":"Engfeldt, B.; Romanus, R.; Yden, S.","year":"1954","unstructured":"Engfeldt B, Romanus R, Yden S. Histological studies of pelvospondylitis ossificans (ankylosing spondylitis) correlated with clinical and radiological findings. Ann Rheum Dis 1954;13:219-28.","journal-title":"Ann Rheum Dis"},{"key":"ref_17","first-page":"314","article-title":"Wood PHN, eds. Population studies of the rheumatic disease. Proceedings of the 3rd international symposium","volume":"1968","author":"Bennett, P.H.","year":"1966","unstructured":"Bennett PH, Wood PHN, eds. Population studies of the rheumatic disease. Proceedings of the 3rd international symposium, New York, 1966. Amsterdam: Excerpta Medica, 1968: 314-6, 456-7.","journal-title":"Amsterdam: Excerpta Medica"},{"key":"ref_18","first-page":"381","article-title":"Lymphocytotoxic micro-technique: purification of lymphocytes by flotation. In: Histocompatibility testing","author":"Kissmeyer-Nielsen, F.; Kjerbye, K.E.","year":"1967","unstructured":"Kissmeyer-Nielsen F, Kjerbye KE. Lymphocytotoxic micro-technique: purification of lymphocytes by flotation. In: Histocompatibility testing. Copenhagen: Munksgaard, 1967: 381-4."},{"key":"ref_19","first-page":"45","article-title":"Qualitative estimation of proteins by electrophoresis","volume":"15","author":"Laurell, C.B.","year":"1966","unstructured":"Laurell CB. Qualitative estimation of proteins by electrophoresis. Ann Biochem 1966;15:45-52."},{"key":"ref_20","first-page":"161","article-title":"Screening for deficiencies in the classical and alternative pathways of complement by hemolysis in gel","volume":"1","author":"Truedsson, L.; Sjoholm, A.G.; Laurell, A.B.","year":"1981","unstructured":"Truedsson L, Sjoholm AG, Laurell AB. Screening for deficiencies in the classical and alternative pathways of complement by hemolysis in gel. Acta Pathol Microbiol Scand,!C1 1981;89:161-6.","journal-title":"Acta Pathol Microbiol Scand,!"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/0002-9343(72)90064-2","article-title":"Mixed connective tissue disease-an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA)","volume":"52","author":"Sharp, G.C.; Irvin, W.S.; Tan, E.M.","year":"1972","unstructured":"Sharp GC, Irvin WS, Tan EM. Mixed connective tissue disease-an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA). Am J Med 1972;52:148-59.","journal-title":"Am J Med"},{"key":"ref_22","first-page":"396","article-title":"Routine assay for the detection of immune complexes of known immunoglobulin class using solid phase Clq. Clin Exp Immunol","volume":"24","author":"Hay, F.C.; Nineham, L.J.; Roitt, I.M.","year":"1976","unstructured":"Hay FC, Nineham LJ, Roitt IM. Routine assay for the detection of immune complexes of known immunoglobulin class using solid phase Clq. Clin Exp Immunol 1976;24:396-400."},{"key":"ref_23","first-page":"342","article-title":"Solid-phase enzyme immunoassay or radioimmunoassay for the detection of immune complexes based on their recognition by conglutinin: conglutinin binding test. Clin Exp Immunol","volume":"29","author":"Casali, P.; Bossus, A.; Carpentier, A.N.","year":"1977","unstructured":"Casali P, Bossus A, Carpentier AN, et al. Solid-phase enzyme immunoassay or radioimmunoassay for the detection of immune complexes based on their recognition by conglutinin: conglutinin binding test. Clin Exp Immunol 1977;29:342-54."},{"key":"ref_24","first-page":"493","article-title":"Evidence for circulating immune complexes in sarcoidosis. Clin Exp Immunol","volume":"16","author":"Hedfors, E.; Norberg, R.","year":"1974","unstructured":"Hedfors E, Norberg R. Evidence for circulating immune complexes in sarcoidosis. Clin Exp Immunol 1974;16: 493-6."},{"key":"ref_25","first-page":"904","article-title":"Ankylosing spondylitis and HL-A27","volume":"i:","author":"Brewerton, D.A.; Caffrey, M.; Hart, F.D.; James, D.C.O.; Nicholls, A.; Sturrock, R.D.","year":"1973","unstructured":"Brewerton DA, Caffrey M, Hart FD, James DCO, Nicholls A, Sturrock RD. Ankylosing spondylitis and HL-A27. Lancet 1973;i:904-7.","journal-title":"Lancet"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1056\/NEJM197304052881403","article-title":"High association of an HL-A antigen, W27, with ankylosing spondylitis","volume":"288","author":"Schlosstein, L.; Terasaki, P.I.; Bluestone, R.; Pearson, C.M.","year":"1973","unstructured":"Schlosstein L, Terasaki PI, Bluestone R, Pearson CM. High association of an HL-A antigen, W27, with ankylosing spondylitis. N Engl J Med 1973;288:704-6.","journal-title":"N Engl J Med"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1365-3083.1974.tb01253.x","article-title":"IgG complexes in serum of rheumatoid arthritis patients","volume":"3","author":"Norberg, R.","year":"1974","unstructured":"Norberg R. IgG complexes in serum of rheumatoid arthritis patients. Scand J Immunol 1974;3:229-36.","journal-title":"Scand J Immunol"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1056\/NEJM198602203140806","article-title":"The pathogenesis of atherosclerosis-an update","volume":"314","author":"Ross, R.","year":"1986","unstructured":"Ross R. The pathogenesis of atherosclerosis-an update. N Engl J Med 1986;314:488-500.","journal-title":"N Engl J Med"},{"key":"ref_29","first-page":"255","article-title":"Clinical and immunological aspects of cutaneous vasculitis","volume":"45","author":"Cream, J.J.","year":"1976","unstructured":"Cream JJ. Clinical and immunological aspects of cutaneous vasculitis. Q J Med 1976;45:255-76.","journal-title":"Q J Med"},{"key":"ref_30","first-page":"241","article-title":"Myocarditis and rheumatic fever predispose to cardiac conduction disturbances. An immunologic study","author":"Maisch, B.; Lotze, U.; Kochsiek, K.; Schneider, J.","year":"1987","unstructured":"Maisch B, Lotze U, Kochsiek K, Schneider J. Myocarditis and rheumatic fever predispose to cardiac conduction disturbances. An immunologic study. In: Belhassen B, Feldman S, Copperman Y, eds. Cardiac pacing and electrophysiology. Proceedings of the VIIIth world symposium on cardiac pacing 1987. Tel Aviv: R & L Creative Communications (Keterprises, Jerusalem), 1987:241-52.","journal-title":"Tel Aviv: R & L Creative Communications (Keterprises, Jerusalem); Cardiac pacing and electrophysiology. Proceedings of the VIIIth world symposium on cardiac pacing 1987"},{"key":"ref_31","first-page":"97","article-title":"Pathology and pathogenesis","author":"Ball, J.","year":"1980","unstructured":"Ball J. Pathology and pathogenesis. In: Moll JMH, ed. Ankylosing spondylitis. Edinburgh, London, Melbourne, New York: Churchill Livingstone, 1980:97-112."},{"key":"ref_32","first-page":"26","author":"In, Woodrow J.C.Genetics","year":"1980","unstructured":"Woodrow JC. Genetics. In: Moll JMH, ed. Ankylosing spondylitis. Edinburgh, London, Melbourne, New York: Churchill Livingstone, 1980:26-41."},{"key":"ref_33","first-page":"42","article-title":"Relationships between ankylosing spondylitis and other spondarthritides","author":"Wright, V.","year":"1980","unstructured":"Wright V. Relationships between ankylosing spondylitis and other spondarthritides. In: Moll JMH, ed. Ankylosing spondylitis. Edinburgh, London, Melbourne, New York: Churchill Livingstone, 1980:42-51."},{"key":"ref_34","first-page":"427","article-title":"Cardiac and aortic lesions","volume-title":"rheumatoid spondylitis. Proc Staff Meet Mayo Clin 1963","volume":"38","author":"Davidson, P.; Baggenstoss, A.H.; Slocumb, C.H.; Daugherty, G.W.","unstructured":"Davidson P, Baggenstoss AH, Slocumb CH, Daugherty GW. Cardiac and aortic lesions in rheumatoid spondylitis. Proc Staff Meet Mayo Clin 1963;38:427-35."},{"key":"ref_35","first-page":"217","article-title":"Cardiac conduction disturbances, an underestimated manifestation in ankylosing spondylitis. A 25-year follow-up study of 68 patients","volume":"212","year":"1982","unstructured":"Bergfeldt L, Edhag 0, Vallin H. Cardiac conduction disturbances, an underestimated manifestation in ankylosing spondylitis. A 25-year follow-up study of 68 patients. Acta Med Scand 1982;212:217-23.","journal-title":"Acta Med Scand"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/hrt.65.4.184","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T01:07:38Z","timestamp":1601082458000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/hrt.65.4.184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,4,1]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1991,4,1]]}},"URL":"https:\/\/doi.org\/10.1136\/hrt.65.4.184","relation":{},"ISSN":["1355-6037"],"issn-type":[{"value":"1355-6037","type":"print"}],"subject":[],"published":{"date-parts":[[1991,4,1]]}}}