{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T01:17:32Z","timestamp":1771636652691,"version":"3.50.1"},"reference-count":21,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[1992,1,1]]},"DOI":"10.1136\/hrt.67.1.92","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T21:46:00Z","timestamp":1190151960000},"page":"92-96","source":"Crossref","is-referenced-by-count":87,"title":["Myocardial dysfunction in treated adult hypopituitarism: a possible explanation for increased cardiovascular mortality."],"prefix":"10.1136","volume":"67","author":[{"given":"M","family":"Shahi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S A","family":"Beshyah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Hackett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P S","family":"Sharp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D G","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R A","family":"Foale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","reference":[{"key":"ref_1","first-page":"1","article-title":"Anterior pituitary","volume-title":"Fundamental of clinical endocrinology","author":"Besser, G.M.","year":"1989","unstructured":"Besser GM. Anterior pituitary. In: Hall R, Besser GM, eds. Fundamental of clinical endocrinology. London: Churchill Livingstone, 1989:1-30."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0140-6736(90)91812-O","article-title":"Premature mortality due to cardiovascular disease in hypopituitarism","volume":"336","author":"Rosen, T.; Bengtsson, B.","year":"1990","unstructured":"Rosen T, Bengtsson B. Premature mortality due to cardiovascular disease in hypopituitarism. Lancet 1990;336: 285-8.","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1056\/NEJM198912283212605","article-title":"The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency","volume":"321","author":"Saloman, F.; Cuneo, R.C.; Hesp, R.; Sonksen, P.H.","year":"1989","unstructured":"Saloman F, Cuneo RC, Hesp R, Sonksen PH. The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency.N EnglJMed 1989;321:1797-803.","journal-title":"N EnglJMed"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1136\/bmj.288.6428.1401","article-title":"Abdominal adipose tissue distribution, obesity and risk of cardiovascular disease and death: 13 year follow-up of participants in the study of men born in 1913","volume":"288","author":"Larsson, B.; Svardsudd, K.; Welin, L.; Wilhelmsen, L.; Bjorntorp, P.; Tibblin, G.","year":"1984","unstructured":"Larsson B, Svardsudd K, Welin L, Wilhelmsen L, Bjorntorp P, Tibblin G. Abdominal adipose tissue distribution, obesity and risk of cardiovascular disease and death: 13 year follow-up of participants in the study of men born in 1913. BMJ 1984;288:1401-4.","journal-title":"BMJ"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1136\/bmj.289.6454.1257","article-title":"Distribution of adipose tissue and risk of cardiovascular disease and death: a 12 year follow-up of participants in the population study ofwomen in Gothenberg, Sweden","volume":"289","author":"Lapidus, L.; Bengtsson, C.; Larrson, B.; Pennert, K.; Rybo, E.; Sjostrom, L.","year":"1984","unstructured":"Lapidus L, Bengtsson C, Larrson B, Pennert K, Rybo E, Sjostrom L. Distribution of adipose tissue and risk of cardiovascular disease and death: a 12 year follow-up of participants in the population study ofwomen in Gothenberg, Sweden. BMJ 1984;289:1257-61.","journal-title":"BMJ"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/0026-0495(72)90036-4","article-title":"Studies of hyperlipidaemia in the hGH-deficient state","volume":"21","author":"Merimee, T.; Hollander, W.; Fineberg, E.","year":"1972","unstructured":"Merimee T, Hollander W, Fineberg E. Studies of hyperlipidaemia in the hGH-deficient state. Metabolism 1972; 21:1053-61.","journal-title":"Metabolism"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0026-0495(82)90121-4","article-title":"Growth hormone in the regulation of hyperlipidaemia","volume":"31","author":"Blackett, P.R.; Weech, P.K.; McConathy, W.J.; Fesmire, J.D.","year":"1982","unstructured":"Blackett PR, Weech PK, McConathy WJ, Fesmire JD. Growth hormone in the regulation of hyperlipidaemia. Metabolism 1982;31:117-20.","journal-title":"Metabolism"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1136\/jcp.25.6.512","article-title":"The relationship of total body potassium to height, weight and age in normal adults","volume":"25","author":"Boddy, K.; King, P.C.; Hume, R.; Weyers, E.","year":"1972","unstructured":"Boddy K, King PC, Hume R, Weyers E. The relationship of total body potassium to height, weight and age in normal adults. J Clin Pathol 1972;25:512-7.","journal-title":"J Clin Pathol"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1177\/000456328602300406","article-title":"The measurement ofinsulin-like growth factor 1: clinical applications and significance","volume":"23","author":"Teale, J.D.; Marks, V.","year":"1986","unstructured":"Teale JD, Marks V. The measurement ofinsulin-like growth factor 1: clinical applications and significance. Ann Clin Biochem 1986;23:413-24.","journal-title":"Ann Clin Biochem"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1136\/hrt.56.1.33","article-title":"Echocardiographic measurement of the normal adult right ventricle","volume":"56","author":"Foale, R.; Nihoyannopoulos, P.; McKenna, W.","year":"1986","unstructured":"Foale R, Nihoyannopoulos P, McKenna W, et al. Echocardiographic measurement of the normal adult right ventricle. Br Heart J 1986;56:33-44.","journal-title":"Br Heart J"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1161\/01.CIR.63.6.1398","article-title":"Quantitation of human left ventricular mass and volume by two-dimensional echocardiography: in vitro validation","volume":"63","author":"Helak, J.W.; Reichekk, N.","year":"1981","unstructured":"Helak JW, Reichekk N. Quantitation of human left ventricular mass and volume by two-dimensional echocardiography: in vitro validation. Circulation 1981; 63:1398-407.","journal-title":"Circulation"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1136\/hrt.59.6.672","article-title":"Influence of aging on Doppler echocardiographic indices ofleft ventricular diastolic function","volume":"59","author":"Spirito, P.; Maron, B.J.","year":"1988","unstructured":"Spirito P, Maron BJ. Influence of aging on Doppler echocardiographic indices ofleft ventricular diastolic function. Br Heart J 1988;59:672-9.","journal-title":"Br Heart J"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1159\/000470723","article-title":"Doppler transmitral flow velocity parameters: relationship between age, body surface area, blood pressure and gender in normal subjects","volume":"1","author":"Gardin, J.M.; Rohan, M.K.; Davidson","year":"1987","unstructured":"Gardin JM, Rohan MK, Davidson, et al. Doppler transmitral flow velocity parameters: relationship between age, body surface area, blood pressure and gender in normal subjects. Am iNoninvas Cardiol 1987;1:3-10.","journal-title":"Am iNoninvas Cardiol"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1542\/peds.32.4.742","article-title":"Exercise testing in adult normal subjects and cardiac patients","volume":"32","author":"Bruce, R.A.; Blackmon, JR, Jones; JW, Strait; G.","year":"1963","unstructured":"Bruce RA, Blackmon JR, Jones JW, Strait G. Exercise testing in adult normal subjects and cardiac patients. Pediatrics 1963;32:742-56.","journal-title":"Pediatrics"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/S0735-1097(84)80141-2","article-title":"Standardisation of M mode echocardiographic left ventricular anatomic measurements","volume":"4","author":"Devereux, R.B.; Lutas, E.M.; Casale, P.N.","year":"1984","unstructured":"Devereux RB, Lutas EM, Casale PN, et al. Standardisation of M mode echocardiographic left ventricular anatomic measurements. JAm Coll Cardiol 1984;4:1222-30.","journal-title":"JAm Coll Cardiol"},{"key":"ref_16","first-page":"357","article-title":"Cardiac architectural changes with hypertrophy induced by excess growth hormone in rats","volume":"59","author":"Lei, L.Q.; Rubin, S.A.; Fishbein, M.C.","year":"1988","unstructured":"Lei LQ, Rubin SA, Fishbein MC, Cardiac architectural changes with hypertrophy induced by excess growth hormone in rats. Lab Invest 1988;59:357-62.","journal-title":"Lab Invest"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/S0140-6736(89)92328-3","article-title":"Beneficial effects of growth hormone treatment in GH-deficient adults","volume":"i:","author":"Jorgensen, J.O.L.; Pedersen, S.A.; Thuesen, L.","year":"1989","unstructured":"Jorgensen JOL, Pedersen SA, Thuesen L, et al. Beneficial effects of growth hormone treatment in GH-deficient adults. Lancet 1989;i:1221-5.","journal-title":"Lancet"},{"key":"ref_18","first-page":"778","article-title":"Congestive heart failure with normal systolic function","volume":"54","author":"Dougherty, A.H.; Naccerelli, G.V.; Gray, E.L.; Hicks, C.H.; Golstein, R.A.","year":"1987","unstructured":"Dougherty AH, Naccerelli GV, Gray EL, Hicks CH, Golstein RA. Congestive heart failure with normal systolic function. Am J Cardiol 1987;54:778-82.","journal-title":"Am J Cardiol"},{"key":"ref_19","first-page":"193","article-title":"Increased myocardial contractility following growth hormone admninistration in normal man: an echocardiographic study","volume":"35","author":"Thuesen, L.; Christiansen, J.S.; Sorensen, K.E.; Jorgensen, J.O.L.; Orskov, H.; Henningsen, P.","year":"1988","unstructured":"Thuesen L, Christiansen JS, Sorensen KE, Jorgensen JOL, Orskov H, Henningsen P. Increased myocardial contractility following growth hormone admninistration in normal man: an echocardiographic study. Dan Med Bull 1988; 35:193-6.","journal-title":"Dan Med Bull"},{"key":"ref_20","first-page":"838","article-title":"Cardiac failure responding to growth hormone","volume":"i:","author":"Cuneo, R.C.; Wilmhurst, P.; Lowy, C.; McGauley, G.; Sonksen, P.H.","year":"1989","unstructured":"Cuneo RC, Wilmhurst P, Lowy C, McGauley G, Sonksen PH. Cardiac failure responding to growth hormone. Lancet 1989;i:838-9.","journal-title":"Lancet"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1161\/01.CIR.70.4.547","article-title":"The abnormal exercise electrocardiogram in apparently healthy men: a predictor of angina pectoris as an initial coronary event during long-term follow-up","volume":"70","author":"McHenry, P.L.; O'Donnell, J.; Morris, S.N.; Jordan, J.J.","year":"1984","unstructured":"McHenry PL, O'Donnell J, Morris SN, Jordan JJ. The abnormal exercise electrocardiogram in apparently healthy men: a predictor of angina pectoris as an initial coronary event during long-term follow-up. Circulation 1984;70:547-52.","journal-title":"Circulation"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/hrt.67.1.92","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,14]],"date-time":"2023-05-14T05:33:28Z","timestamp":1684042408000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/hrt.67.1.92"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,1,1]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1992,1,1]]}},"URL":"https:\/\/doi.org\/10.1136\/hrt.67.1.92","relation":{},"ISSN":["1355-6037"],"issn-type":[{"value":"1355-6037","type":"print"}],"subject":[],"published":{"date-parts":[[1992,1,1]]}}}