{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:00:19Z","timestamp":1788994819504,"version":"build-2803163510"},"reference-count":31,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[1993,11,1]]},"DOI":"10.1136\/hrt.70.5.461","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T21:46:00Z","timestamp":1190151960000},"page":"461-468","source":"Crossref","is-referenced-by-count":62,"title":["Profile of paediatric patients with pulmonary hypertension judged by responsiveness to vasodilators."],"prefix":"10.1136","volume":"70","author":[{"given":"C","family":"Houde","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D J","family":"Bohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R M","family":"Freedom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Rabinovitch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","reference":[{"key":"ref_1","first-page":"1414","article-title":"Primary pulmonary hypertension: Favorable effect of isoproterenol","volume":"295","author":"Shettiger, U.R.; Hultgren, H.N.; Specter, M.","year":"1976","unstructured":"Shettiger UR, Hultgren HN, Specter M, et al. Primary pulmonary hypertension: Favorable effect of isoproterenol. NEnglJ7Med 1976;295:1414-5."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1056\/NEJM198001103020204","article-title":"Diazoxide in primary pulmonary hypertension","volume":"302","author":"Klinke, W.P.; Gilbert, J.A.L.","year":"1980","unstructured":"Klinke WP, Gilbert JAL. Diazoxide in primary pulmonary hypertension. N Engl Med 1980;302:91-2.","journal-title":"N Engl Med"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1056\/NEJM198206033062203","article-title":"Deleterious effects of hydralazine in patients with primary pulmonary hypertension","volume":"306","author":"Packer, M.B.; Greenberg, B.; Massie, B.","year":"1982","unstructured":"Packer MB, Greenberg B, Massie B, et al. Deleterious effects of hydralazine in patients with primary pulmonary hypertension. N Engl J Med 1982;306:1326-31.","journal-title":"N Engl J Med"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1378\/chest.95.6.1173","article-title":"Is it ethical to administer vasodilator drugs to patients with primary pulmonary hypertension?","volume":"95","author":"Packer, M.","year":"1989","unstructured":"Packer M. Is it ethical to administer vasodilator drugs to patients with primary pulmonary hypertension? Chest 1989;95:1173-4.","journal-title":"Chest"},{"key":"ref_5","first-page":"901","article-title":"Treatment for primary pulmonary hypertension: back to the future","volume":"96","author":"McManigle, J.E.; Tenholder, M.F.","year":"1989","unstructured":"McManigle JE, Tenholder MF. Treatment for primary pulmonary hypertension: back to the future. Chest 1989; 96:901-5.","journal-title":"Chest"},{"key":"ref_6","first-page":"513","article-title":"Etiologic mechanisms in primary pulmonary hypertension","volume-title":"vascular physiology and pathophysiology","author":"Voelkel, N.F.; Weir, E.K.","year":"1989","unstructured":"Voelkel NF, Weir EK. Etiologic mechanisms in primary pulmonary hypertension. In: Weir EK, Reeves JT, eds. Pldmonary vascular physiology and pathophysiology. New York: Marcel Dekker 1989:513-39."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/S0022-5223(19)36651-6","article-title":"Single lung transplantation: alternative indications and technique","volume":"101","author":"Calhoon, J.H.; Grover, F.L.; Gibbons, W.J.","year":"1991","unstructured":"Calhoon JH, Grover FL, Gibbons WJ, et al. Single lung transplantation: alternative indications and technique. J Thorac Cardiovasc Surg 1991;101:816-25.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"ref_8","first-page":"1209","article-title":"Single lung transplantation: a new option for patients with","volume-title":"pulmonary hypertension. Transplant Proc","volume":"23","author":"Starnes, V.A.; Stinson, E.B.; Oyer, P.E.","year":"1991","unstructured":"Starnes VA, Stinson EB, Oyer PE, et al. Single lung transplantation: a new option for patients with pulmonary hypertension. Transplant Proc 1991;23:1209-10."},{"key":"ref_9","first-page":"2275","article-title":"Singlelung transplantation for pulmonary","volume":"84","author":"Pasque, M.K.; Elbert, P.T.; Kaiser, L.R.; Cooper, J.D.","year":"1991","unstructured":"Pasque MK, Elbert PT, Kaiser LR, Cooper JD. Singlelung transplantation for pulmonary hypertension: three month hemodynamic follow-up. Circulation 1991;84: 2275-79."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"216","DOI":"10.7326\/0003-4819-107-2-216","article-title":"Primary pulmonary hypertension: a national prospective study","volume":"107","author":"Rich, S.; Dantzker, D.R.; Ayres, S.M.","year":"1987","unstructured":"Rich S, Dantzker DR, Ayres SM, et al. Primary pulmonary hypertension: a national prospective study. Ann Intern Med 1987;107:216-23.","journal-title":"Ann Intern Med"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1161\/01.CIR.18.4.533","article-title":"The pathology of hypertensive pulmonary vascular disease","volume":"18","author":"Heath, D.; Edwards, J.E.","year":"1958","unstructured":"Heath D, Edwards JE. The pathology of hypertensive pulmonary vascular disease. Circulation 1958;18:533-47.","journal-title":"Circulation"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1161\/01.CIR.58.6.1107","article-title":"Lung biopsy in congenital heart disease: a morphometnic approach to pulmonary vascular disease","volume":"58","author":"Rabinovitch, M.; Haworth, S.G.; Castaneda, A.R.","year":"1978","unstructured":"Rabinovitch M, Haworth SG, Castaneda AR, et al. Lung biopsy in congenital heart disease: a morphometnic approach to pulmonary vascular disease. Circulation 1978;58:1107-22.","journal-title":"Circulation"},{"key":"ref_13","first-page":"143","article-title":"Clinical measurement of vascular resistance and assessment of vasodilator drugs","author":"Grossman, W.","year":"1991","unstructured":"Grossman W. Clinical measurement of vascular resistance and assessment of vasodilator drugs. In: Grossman W, ed. Cardiac catheterization and angiography. Philadelphia: Lea and Febiger, 1991:143-51.","journal-title":"Philadelphia: Lea and Febiger; catheterization and angiography"},{"key":"ref_14","first-page":"63","article-title":"Primary pulmonary hypertension: modes of diagnosis and aggressive treatment with vasodilators","volume":"57","author":"Rich, S.","year":"1990","unstructured":"Rich S. Primary pulmonary hypertension: modes of diagnosis and aggressive treatment with vasodilators. Mt SinaiJMed 1990;57:63-73.","journal-title":"Mt SinaiJMed"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1542\/peds.36.1.75","article-title":"Primary pulmonary vascular obstruction in children","volume":"36","author":"Thilenius, O.G.; Nadas, A.S.; Jockin, H.","year":"1965","unstructured":"Thilenius OG, Nadas AS, Jockin H. Primary pulmonary vascular obstruction in children. Pediatrics 1965;36: 75-87.","journal-title":"Pediatrics"},{"key":"ref_16","first-page":"217","article-title":"Idiopathic pulmonary hypertension in infancy and childhood","volume":"79","author":"Robertson, B.","year":"1971","unstructured":"Robertson B. Idiopathic pulmonary hypertension in infancy and childhood. Acta Pathologica et Microbiologica Scandinavica 1971;79:217-27.","journal-title":"Acta Pathologica et Microbiologica Scandinavica"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0022-3476(84)80413-8","article-title":"Pulmonary hypertension in paediatric patients","volume":"105","author":"Perkin, R.M.; Anas, N.G.","year":"1984","unstructured":"Perkin RM, Anas NG. Pulmonary hypertension in paediatric patients. J Pediatr 1984;105:511-22.","journal-title":"J Pediatr"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1378\/chest.89.4.497","article-title":"Pharmacologically induced pulmonary vasodilatation in children and young adults with primary pulmonary hypertension","volume":"89","author":"Barst, R.J.","year":"1986","unstructured":"Barst RJ. Pharmacologically induced pulmonary vasodilatation in children and young adults with primary pulmonary hypertension. Chest 1986;89:497-503.","journal-title":"Chest"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1164\/ajrccm\/140.6.1623","article-title":"The acute administration of vasodilators in primary pulmonary hypertension","volume":"140","author":"Weir, E.K.; Rubin, L.J.; Ayres, S.M.","year":"1989","unstructured":"Weir EK, Rubin LJ, Ayres SM, et al. The acute administration of vasodilators in primary pulmonary hypertension. Am Rev Respir Dis 1989;140:1623-30.","journal-title":"Am Rev Respir Dis"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1161\/01.CIR.70.4.580","article-title":"Primary pulmonary hypertension: natural history and the importance of thrombosis","volume":"70","author":"Fuster, V.; Steele, P.M.; Edwards, W.D.","year":"1984","unstructured":"Fuster V, Steele PM, Edwards WD, et al. Primary pulmonary hypertension: natural history and the importance of thrombosis. Circulation 1984;70:580-7.","journal-title":"Circulation"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1136\/hrt.55.5.449","article-title":"Factors that influence the outcome of primary pulmonary hypertension","volume":"55","author":"Rozkovec, A.; Montanes, P.; Oakley, C.M.","year":"1986","unstructured":"Rozkovec A, Montanes P, Oakley CM. Factors that influence the outcome of primary pulmonary hypertension. Br HeartJ 1986;55:449-58.","journal-title":"Br HeartJ"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/0002-9149(78)90872-X","article-title":"Left ventricular function in chronic pulmonary hypertension","volume":"41","year":"1978","unstructured":"Krayenbuehl HP, Turina J, Hess 0. Left ventricular function in chronic pulmonary hypertension. Am Jf Cardiol 1978;41:1150-8.","journal-title":"Am Jf Cardiol"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"343","DOI":"10.7326\/0003-4819-115-5-343","article-title":"Survival in patients with primary pulmonary hypertenson: results from a national prospective registry","volume":"115","author":"D'Alonzo, G.E.; Barst, R.J.; Ayres, S.M.","year":"1991","unstructured":"D'Alonzo GE, Barst RJ, Ayres SM, et al. Survival in patients with primary pulmonary hypertenson: results from a national prospective registry. Ann Intern Med 1991;115:343-9.","journal-title":"Ann Intern Med"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1161\/01.CIR.82.6.2018","article-title":"Prostacyclin and acetylcholine as screening agents for acute pulmonary vasodilator responsiveness in primary pulmonary hypertension","volume":"82","author":"Palevsky, H.I.; Long, W.; Crow, J.; Fishman, A.P.","year":"1990","unstructured":"Palevsky HI, Long W, Crow J, Fishman AP. Prostacyclin and acetylcholine as screening agents for acute pulmonary vasodilator responsiveness in primary pulmonary hypertension. Circulation 1990;82:2018-26.","journal-title":"Circulation"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1164\/ajrccm\/136.3.773","article-title":"Prostacyclin and PGE, treatment of pulmonary hypertension","volume":"136","author":"Long, W.A.; Rubin, U.","year":"1987","unstructured":"Long WA, Rubin U. Prostacyclin and PGE, treatment of pulmonary hypertension. Am Rev Respir Dis 1987; 136:773-6.","journal-title":"Am Rev Respir Dis"},{"key":"ref_26","first-page":"231","article-title":"The acute effect of the synthetic prostacyclin analogue iloprost in primary pulmonary hypertension","volume":"44","author":"Scott, J.P.; Higenbottam, T.; Wallwork, J.","year":"1990","unstructured":"Scott JP, Higenbottam T, Wallwork J. The acute effect of the synthetic prostacyclin analogue iloprost in primary pulmonary hypertension. BrJ Clin PIract 1990;44:231-4.","journal-title":"BrJ Clin PIract"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"485","DOI":"10.7326\/0003-4819-112-7-485","article-title":"Treatmnent of primary pulmonary hypertension with continuous intravenous prostacyclin (epoprostenol): results of a randomized trial","volume":"112","author":"Rubin, U.; Mendoza, J.; Hood, M.","year":"1990","unstructured":"Rubin U, Mendoza J, Hood M, et al. Treatmnent of primary pulmonary hypertension with continuous intravenous prostacyclin (epoprostenol): results of a randomized trial. Ann Intern Med 1990;112:485-91.","journal-title":"Ann Intern Med"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1001\/jama.1991.03460080084038","article-title":"The management of primary pulmonary hypertension","volume":"265","author":"Palevsky, H.I.; Fishman, A.P.","year":"1991","unstructured":"Palevsky HI, Fishman AP. The management of primary pulmonary hypertension. JAMA 1991;265: 1014-20.","journal-title":"JAMA"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0002-8703(83)90288-0","article-title":"Reassessment of the effects of vasodilator drugs in primary pulmonary hypertension: guidelines for determining a pulmonary vasodilator response","volume":"105","author":"Rich, S.; Martinez, J.; Lam, W.; Levy, P.S.; Rosen, K.M.","year":"1983","unstructured":"Rich S, Martinez J, Lam W, Levy PS, Rosen KM. Reassessment of the effects of vasodilator drugs in primary pulmonary hypertension: guidelines for determining a pulmonary vasodilator response. Am HeartJ 1983; 105:119-27.","journal-title":"Am HeartJ"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1161\/01.CIR.71.6.1191","article-title":"The effect of vasodilator therapy on the clinical outcome of patients with primary pulmonary hypertension","volume":"71","author":"Rich, S.; Brundage, B.H.; Levy, P.S.","year":"1985","unstructured":"Rich S, Brundage BH, Levy PS. The effect of vasodilator therapy on the clinical outcome of patients with primary pulmonary hypertension. Circulation 1985;71:1191-6.","journal-title":"Circulation"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1161\/01.CIR.76.1.135","article-title":"High-dose calcium channel-blocking therapy for primary pulmonary hypertension: evidence for long-term reduction in pulmonary arterial pressure and regression of right ventricular hypertrophy","volume":"76","author":"Rich, S.; Brundage, B.H.","year":"1987","unstructured":"Rich S, Brundage BH. High-dose calcium channel-blocking therapy for primary pulmonary hypertension: evidence for long-term reduction in pulmonary arterial pressure and regression of right ventricular hypertrophy. Circulation 1987;76:135-41.","journal-title":"Circulation"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/hrt.70.5.461","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T02:41:11Z","timestamp":1737427271000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/hrt.70.5.461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,11,1]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1993,11,1]]}},"URL":"https:\/\/doi.org\/10.1136\/hrt.70.5.461","relation":{},"ISSN":["1355-6037"],"issn-type":[{"value":"1355-6037","type":"print"}],"subject":[],"published":{"date-parts":[[1993,11,1]]}}}