{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:00:19Z","timestamp":1788994819718,"version":"build-2803163510"},"reference-count":30,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[1994,3,1]]},"DOI":"10.1136\/hrt.71.3.282","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T21:46:00Z","timestamp":1190151960000},"page":"282-286","source":"Crossref","is-referenced-by-count":48,"title":["Effect of inhaled nitric oxide on raised pulmonary vascular resistance in children with congenital heart disease."],"prefix":"10.1136","volume":"71","author":[{"given":"P.","family":"Winberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. P.","family":"Lundell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. E.","family":"Gustafsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1161\/01.CIR.64.5.873","article-title":"Pulmonary vascular disease with congenital heart lesions: Pathologic features and causes","volume":"64","author":"Hoffman, J.I.E.; Rudolph, A.M.; Heyman, M.A.","year":"1981","unstructured":"Hoffman JIE, Rudolph AM, Heyman MA. Pulmonary vascular disease with congenital heart lesions: Pathologic features and causes. Circulation. 1981;64:873-7.","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/1010-7940(91)90118-4","article-title":"Pulmonary hypertensive crises following surgery for congenital heart defects in young children","volume":"5","author":"Hopkins, R.A.; Bull, C.; Haworth, S.G.; de Laval, M.R.; Stark, J.","year":"1991","unstructured":"Hopkins RA, Bull C, Haworth SG, de Laval MR, Stark J. Pulmonary hypertensive crises following surgery for congenital heart defects in young children. Eur Jf Cardiothorac Surg 1991;5:628-34.","journal-title":"Eur Jf Cardiothorac Surg"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/327524a0","article-title":"Nitric oxide release accounts for the biological activity of endothelium derived relaxing factor","volume":"327","author":"Palmer, R.M.J.; Ferrige, A.G.; Moncada, S.","year":"1987","unstructured":"Palmer RMJ, Ferrige AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium derived relaxing factor. Nature 1987;327:524-6.","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"9265","DOI":"10.1073\/pnas.84.24.9265","article-title":"Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide","volume":"84","author":"Ignarro, U.; Buga, G.M.; Wood, K.S.; Byrnes, R.E.; Chaudhuri, G.","year":"1987","unstructured":"Ignarro U, Buga GM, Wood KS, Byrnes RE, Chaudhuri G. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Nail Acad Sci USA 1987;84:9265-9.","journal-title":"Proc Nail Acad Sci USA"},{"key":"ref_5","first-page":"109","article-title":"Nitric oxide: Pathophysiology, and pharmacology","volume":"43","author":"Moncada, S.; Palmer, R.M.J.; Higg, E.A.","year":"1991","unstructured":"Moncada S, Palmer RMJ, Higg EA. Nitric oxide: Pathophysiology, and pharmacology. Pharmacol Rev 1991;43:109-42.","journal-title":"Pharmacol Rev"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1748-1716.1990.tb09021.x","article-title":"Endogenous nitric oxide as a probable modulator of pulmonary circulation and hypoxic pressor response in vivo","volume":"140","author":"Persson, M.G.; Gustafsson, L.E.; Wiklund, N.P.; Moncada, S.; Hedqvist, P.","year":"1990","unstructured":"Persson MG, Gustafsson LE, Wiklund NP, Moncada S, Hedqvist P. Endogenous nitric oxide as a probable modulator of pulmonary circulation and hypoxic pressor response in vivo. Acta Physiol Scand 1990;140:449-57.","journal-title":"Acta Physiol Scand"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/0006-291X(91)91268-H","article-title":"Endogeneous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans","volume":"181","author":"Gustafsson, L.E.; Leone, A.M.; Persson, M.G.; Wiklund, N.P.; Moncada, S.","year":"1991","unstructured":"Gustafsson LE, Leone AM, Persson MG, Wiklund NP, Moncada S. Endogeneous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans. Biochem Biophys Res Commum 1991;181:852-7.","journal-title":"Biochem Biophys Res Commum"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1113\/jphysiol.1957.sp005777","article-title":"The kinetics and equilibration of reactions of nitric oxide with sheep hemoglobin","volume":"136","author":"Gibson, Q.H.; Roughton, F.I.W.","year":"1957","unstructured":"Gibson QH, Roughton FIW. The kinetics and equilibration of reactions of nitric oxide with sheep hemoglobin. J Physiol 1957;136:507-26.","journal-title":"J Physiol"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1161\/01.CIR.83.6.2038","article-title":"Inhaled nitric oxide: A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction","volume":"83","author":"Frostell, C.; Fratacci, M.D.; Wain, J.C.; Jones, R.; Zapol, W.M.","year":"1991","unstructured":"Frostell C, Fratacci MD, Wain JC, Jones R, Zapol WM. Inhaled nitric oxide: A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction. Circulation 1991;83:2038-47.","journal-title":"Circulation"},{"key":"ref_10","first-page":"413","article-title":"Inhaled nitric oxide selectively reverses human hypoxic pulmonary vasoconstriction without causing systemic vasodilatation","volume":"78","author":"Frostell, C.G.; Hedenstierna, Blomqvist H.; G, Lundberg; J, Zapol; W.M.","year":"1993","unstructured":"Frostell CG, Blomqvist H Hedenstierna G, Lundberg J, Zapol WM. Inhaled nitric oxide selectively reverses human hypoxic pulmonary vasoconstriction without causing systemic vasodilatation. Anesthesiology 1993;78: 413-6.","journal-title":"Anesthesiology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/0140-6736(92)92686-A","article-title":"Inhaled nitric oxide in persistent pulmonary hypertension of the newborn","volume":"340","author":"Roberts, J.D.; Polander, D.M.; Lang, P.; Zapol, W.M.","year":"1992","unstructured":"Roberts JD, Polander DM, Lang P, Zapol WM. Inhaled nitric oxide in persistent pulmonary hypertension of the newborn. Lancet 1992;340:818-9.","journal-title":"Lancet"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/0140-6736(92)92687-B","article-title":"Low-dose inhalational nitric oxide in persistent pulmonary hypertension of the newborn","volume":"340","author":"Kinsella, J.P.; Neish, SR, Shaffer; E, Abman; S.H.","year":"1992","unstructured":"Kinsella JP, Neish SR, Shaffer E, Abman SH. Low-dose inhalational nitric oxide in persistent pulmonary hypertension of the newborn. Lancet 1992;340:819-20.","journal-title":"Lancet"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1056\/NEJM199302113280605","article-title":"Inhaled nitric oxide for the adult respiratory distress syndrome","volume":"328","author":"Rossaint, R.; Falke, K.J.; Pison, U.; Lopez, F.; Slama, K.; Pison, U.; Zapol, W.M.","year":"1993","unstructured":"Rossaint R, Falke KJ, Pison U, Lopez F, Slama K, Pison U, Zapol WM. Inhaled nitric oxide for the adult respiratory distress syndrome. N Engl J Med 1993;328: 399-405.","journal-title":"N Engl J Med"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1161\/01.CIR.87.2.447","article-title":"Inhaled nitric oxide in congenital heart disease","volume":"87","year":"1993","unstructured":"Roberts Jr JD, Lang P, Bigatello LM, Vlahakes GJ, Zapol WM. Inhaled nitric oxide in congenital heart disease. Circulation 1993;87:447-53.","journal-title":"Circulation"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1097\/00000542-199303000-00021","article-title":"Inhalation of nitric oxide reduced pulmonary hypertension after cardiac surgery in a 3-2 kg infant","volume":"78","author":"Sellden, H.; Winberg, P.; Gustafsson, L.G.; Lundell, B.; Book, K.; Frostell, C.G.","year":"1993","unstructured":"Sellden H, Winberg P, Gustafsson LG, Lundell B, Book K, Frostell CG. Inhalation of nitric oxide reduced pulmonary hypertension after cardiac surgery in a 3-2 kg infant. Anesthesiology 1993;78:577-80.","journal-title":"Anesthesiology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0013-9351(85)90116-1","article-title":"Effects of exposure of blood hemoglobin to nitric oxide","volume":"37","author":"Chiodi, H.; Mohler, J.G.","year":"1985","unstructured":"Chiodi H, Mohler JG. Effects of exposure of blood hemoglobin to nitric oxide. Environ Res 1985;37:355-63.","journal-title":"Environ Res"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3109\/08958379009145245","article-title":"Nitric oxide and nitrogen dioxide as inducers of acute pulmonary injury when inhaled at relatively high concentrations for a brief period","volume":"2","author":"Stavert, D.M.; Lehnert, B.E.","year":"1975","unstructured":"Stavert DM, Lehnert BE. Nitric oxide and nitrogen dioxide as inducers of acute pulmonary injury when inhaled at relatively high concentrations for a brief period. Inhal Toxicol 1975;2:53-67.","journal-title":"Inhal Toxicol"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/BF00377770","article-title":"Effect of exposure to 43 ppm nitric oxide and 3-6 ppm nitrogen dioxide on rabbit lung","volume":"42","author":"Hugod, C.","year":"1978","unstructured":"Hugod C. Effect of exposure to 43 ppm nitric oxide and 3-6 ppm nitrogen dioxide on rabbit lung. Int Arch Occup Environ Health 1978;42:159-67.","journal-title":"Int Arch Occup Environ Health"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/BF00377770","article-title":"Effect of exposure to 43 ppm nitric oxide and 3-6 ppm nitrogen dioxide on rabbit lung","volume":"42","author":"Hugod, C.","year":"1978","unstructured":"Hugod C. Effect of exposure to 43 ppm nitric oxide and 3-6 ppm nitrogen dioxide on rabbit lung. Int Arch Occup Environ Health 1978;42:159-67.","journal-title":"Int Arch Occup Environ Health"},{"key":"ref_20","first-page":"175","article-title":"Vergleich der wirkung von stickstoffdioxide und stickstoffmonoxide auf die lungenfunktion des menschen","volume":"35","author":"von Nieding G; HM, Wagner","year":"1975","unstructured":"von Nieding G, Wagner HM. Vergleich der wirkung von stickstoffdioxide und stickstoffmonoxide auf die lungenfunktion des menschen. Staub-Reinhart Luft 1975;35: 175-8.","journal-title":"Staub-Reinhart Luft"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1097\/00000542-198105000-00016","article-title":"An automated oscillometric technique for estimating mean arterial pressure in critically ill newborns","volume":"54","author":"Kimble, K.J.; Darnall, R.; Ayelderman, M.; Ariagno, R.L.; Ream, A.K.","year":"1981","unstructured":"Kimble KJ, Darnall R, Ayelderman M, Ariagno RL, Ream AK. An automated oscillometric technique for estimating mean arterial pressure in critically ill newborns. Anesthesiology 1981;54:423-5.","journal-title":"Anesthesiology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1021\/ac60288a034","article-title":"Homogeneous chemiluminescent measurement of nitric oxide with ozone","volume":"42","author":"Fontijn, A.; Sabadell, A.J.; Ronco, R.J.","year":"1970","unstructured":"Fontijn A, Sabadell AJ, Ronco RJ. Homogeneous chemiluminescent measurement of nitric oxide with ozone. Anal Chem 1970;42:575-9.","journal-title":"Anal Chem"},{"key":"ref_23","first-page":"21","article-title":"OSHA excursion limits. MMWR Morb Mortal Wkly Rep","volume":"37","year":"1988","unstructured":"OSHA excursion limits. MMWR Morb Mortal Wkly Rep 1988;37:21."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/205915b0","article-title":"Nitrogen oxide in tobacco smoke","volume":"205","author":"Norman, V.; Keith, C.","year":"1965","unstructured":"Norman V, Keith C. Nitrogen oxide in tobacco smoke. Nature 1965;205:915-6.","journal-title":"Nature"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/0735-1097(89)90090-9","article-title":"Pulmonary hypertension: A cellular basis for understanding the pathophysiology and treatment","volume":"11","author":"Rich, S.; Brundage, B.H.","year":"1989","unstructured":"Rich S, Brundage BH. Pulmonary hypertension: A cellular basis for understanding the pathophysiology and treatment. J Am Coil Cardiol 1989;11:545-50.","journal-title":"J Am Coil Cardiol"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1161\/01.CIR.87.2.440","article-title":"Impairment of endothelium-dependent pulmonary artery relaxation in infants with congenital heart disease and abnormal pulmonary hemodynamics","volume":"87","author":"Celermajer, D.S.; Cullen, S.; Deanfield, J.E.","year":"1993","unstructured":"Celermajer DS, Cullen S, Deanfield JE. Impairment of endothelium-dependent pulmonary artery relaxation in infants with congenital heart disease and abnormal pulmonary hemodynamics. Circulation 1993;87:440-6.","journal-title":"Circulation"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0022-3476(75)80142-9","article-title":"The pulmonary vascular bed in children with Down syndrome","volume":"86","author":"Chi, T.; Krovetz, J.","year":"1975","unstructured":"Chi T, Krovetz J. The pulmonary vascular bed in children with Down syndrome. Pediatrics 1975;86:533-8.","journal-title":"Pediatrics"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1056\/NEJM198211043071902","article-title":"Pulmonary hypoplasia in Down syndrome","volume":"307","author":"Cooney, T.P.; Thurlbeck, W.M.","year":"1982","unstructured":"Cooney TP, Thurlbeck WM. Pulmonary hypoplasia in Down syndrome. N EnglJ7 Med 1982;307:1170-3.","journal-title":"N EnglJ7 Med"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1177\/000992288202100104","article-title":"Alveolar hypoventilation and cor pulmonale associated with chronic airway obstruction in infants with Down syndrome","volume":"21","author":"Levine, R.O.; Simpser, M.","year":"1982","unstructured":"Levine RO, Simpser M. Alveolar hypoventilation and cor pulmonale associated with chronic airway obstruction in infants with Down syndrome. Clin Pediatr 1982;21: 25-9.","journal-title":"Clin Pediatr"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/0002-9149(86)90623-5","article-title":"Pulmonary vascular bed in children with complete atrioventricular defect: Relation between structural and hemodynamic abnormalities","volume":"57","author":"Haworth, S.G.","year":"1986","unstructured":"Haworth SG. Pulmonary vascular bed in children with complete atrioventricular defect: Relation between structural and hemodynamic abnormalities. Am J Cardiol 1986;57:833-9.","journal-title":"Am J Cardiol"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/hrt.71.3.282","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T01:05:11Z","timestamp":1601082311000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/hrt.71.3.282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,3,1]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1994,3,1]]}},"URL":"https:\/\/doi.org\/10.1136\/hrt.71.3.282","relation":{},"ISSN":["1355-6037"],"issn-type":[{"value":"1355-6037","type":"print"}],"subject":[],"published":{"date-parts":[[1994,3,1]]}}}