{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T10:52:06Z","timestamp":1763808726639,"version":"3.44.0"},"reference-count":38,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[1996,2]]},"abstract":"<jats:p>OBJECTIVE: To investigate whether patients with constrictive pericarditis have changes in collagen content and architecture that could influence left ventricular function. DESIGN: Cohort study. SETTING: University teaching hospital. PATIENTS: Biopsy specimens of myocardium from 13 patients admitted consecutively for treatment of chronic constrictive pericarditis were compared with normal heart tissue taken at necropsy from 15 patients free of cardiac disease. INTERVENTION: Pericardiectomy through median sternotomy. Biopsy specimens (4 or 5) were taken from the left ventricular free wall. MAIN OUTCOME MEASURES: Biochemical and histological assessment of total collagen content, relative proportion of type I and III collagen, and amount of orthogonal collagen fibre meshwork (crosshatching) in the left ventricular tissue. RESULTS: There was more collagen in the myocardium of patients with constrictive pericarditis than in controls when measured either biochemically by hydroxyproline content (89.4 v 50.4 mg\/g dry weight) or by histological measurement of the collagen fraction of the myocardium (2.4% v 7.0%). Neither of these measurements, however, correlated with left ventricular ejection fraction, pulmonary wedge pressure, or right ventricular end diastolic pressure. The thickness of the fibrous trabeculae in the myocardium was, however, inversely related to both left ventricular ejection fraction (r = -0.76) and deceleration time (r = -0.68). Trabecular thickening was also related to NYHA class, with those in class III and IV having the greatest thickening. CONCLUSION: Changes in collagen content and architecture may contribute to impaired ventricular function in patients with chronic constrictive pericarditis.<\/jats:p>","DOI":"10.1136\/hrt.75.2.184","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:46:00Z","timestamp":1190137560000},"page":"184-189","source":"Crossref","is-referenced-by-count":14,"title":["Collagen network remodelling and left ventricular function in constrictive pericarditis."],"prefix":"10.1136","volume":"75","author":[{"given":"M.","family":"Chello","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Mastroroberto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Romano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Perticone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. R.","family":"Marchese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1996,2,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/S0022-5223(19)38783-5","article-title":"Early and late results of pericardiectomy for constrictive pericarditis","volume":"89","author":"McCaughan, B.C.; Hartzell, V.; Schaff, H.V.; Piehler, J.M.; Danielson, G.K.; Orsulak, T.A.","year":"1985","unstructured":"McCaughan BC, Hartzell V, Schaff HV, Piehler JM, Danielson GK, Orsulak TA, et al. Early and late results of pericardiectomy for constrictive pericarditis. J Thorac Cardiovasc Surg 1985;89:340-50.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"ref_2","first-page":"219","article-title":"Current indications, risks, and outcome after pericardiectomy","volume-title":"Collagen network remodelling and left ventricularfunction in constrictive pericarditis","volume":"52","author":"PA, De Valeria; WA, Baumgartner; AS, Casale; PS, Greene; DE, Cameron; TJ, Gardner","year":"1991","unstructured":"De Valeria PA, Baumgartner WA, Casale AS, Greene PS, Cameron DE, Gardner TJ, et al. Current indications, risks, and outcome after pericardiectomy. Ann Thorac Surg 1991;52:219-24. Collagen network remodelling and left ventricularfunction in constrictive pericarditis"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0003-4975(10)60850-8","article-title":"Pericardiectomy: current indications, concepts, and results in a university center","volume":"34","author":"Miller, J.I.; Mansour, K.A.; Hatcher, C.R.","year":"1982","unstructured":"Miller JI, Mansour KA, Hatcher CR. Pericardiectomy: current indications, concepts, and results in a university center. Ann Thorac Surg 1982;34:40-5.","journal-title":"Ann Thorac Surg"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1161\/01.CIR.48.5.1038","article-title":"The influence of pericardiectomy on the hemodynamics of chronic constrictive pericarditis","volume":"48","author":"Viola, A.R.","year":"1973","unstructured":"Viola AR. The influence of pericardiectomy on the hemodynamics of chronic constrictive pericarditis. Circulation 1973;48: 1038-42.","journal-title":"Circulation"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1161\/01.CIR.32.3.415","article-title":"Hemodynamic studies following pericardiectomy for constrictive pericarditis","volume":"32","author":"Kloster, F.E.; Crislip, R.L.; Bristow, J.D.; Herr, R.H.; Ritzman, L.W.; Griswold, H.E.","year":"1965","unstructured":"Kloster FE, Crislip RL, Bristow JD, Herr RH, Ritzman LW, Griswold HE. Hemodynamic studies following pericardiectomy for constrictive pericarditis. Circulation 1965;32:415-24.","journal-title":"Circulation"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/BF01906668","article-title":"Connective tissue content and myocardial stiffness in pressure overload hypertrophy. A combined study of morphologic, morphometric, biochemical and mechanical parameters","volume":"78","author":"Thiedemann, K.U.; Houbarsch, C.H.; Medugoral, I.; Jacob, R.","year":"1983","unstructured":"Thiedemann KU, Houbarsch CH, Medugoral I, Jacob R. Connective tissue content and myocardial stiffness in pressure overload hypertrophy. A combined study of morphologic, morphometric, biochemical and mechanical parameters. Bas Res Cardiol 1983;78:140-55.","journal-title":"Bas Res Cardiol"},{"key":"ref_7","first-page":"364","article-title":"The collagen network of the heart","volume-title":"Lab Invest","volume":"40","author":"Caulfield, J.B.; Borg, T.K.","year":"1979","unstructured":"Caulfield JB, Borg TK. The collagen network of the heart. Lab Invest 1979;40:364-72."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/BF01908312","article-title":"Characterization of intramuscular collagen in the mammalian left ventricle","volume":"77","author":"Medugoral, I.","year":"1982","unstructured":"Medugoral I. Characterization of intramuscular collagen in the mammalian left ventricle. Bas Res Cardiol 1982;77: 589-98.","journal-title":"Bas Res Cardiol"},{"key":"ref_9","first-page":"165","article-title":"Biochemical characteristics and biological significance of the genetically distinct collagens","volume":"130","author":"Miller, E.J.","year":"1975","unstructured":"Miller EJ. Biochemical characteristics and biological significance of the genetically distinct collagens. Mol Cell Biochem 1975;130:165-93.","journal-title":"Mol Cell Biochem"},{"key":"ref_10","first-page":"609","article-title":"Correlations of fibrosis in endomyocardial biopsies from patients with aortic valve disease","volume":"44","author":"Oldershaw, P.J.; Brooksby, I.A.B.; Davies, M.J.; Coltart, D.J.; Jenkins, B.S.; Webb-Peploe, M.M.","year":"1980","unstructured":"Oldershaw PJ, Brooksby IAB, Davies MJ, Coltart DJ, Jenkins BS, Webb-Peploe MM. Correlations of fibrosis in endomyocardial biopsies from patients with aortic valve disease. BrHeartJ 1980;44:609-1 1.","journal-title":"BrHeartJ"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/path.1711280205","article-title":"Histopathological types of cardiac fibrosis in myocardial disease","volume":"128","author":"Anderson, K.R.; St John Sutton, M.G.; Lie, J.T.","year":"1979","unstructured":"Anderson KR, St John Sutton MG, Lie JT. Histopathological types of cardiac fibrosis in myocardial disease. J Pathol 1979;128:79-85.","journal-title":"J Pathol"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1161\/01.RES.42.4.459","article-title":"The structural proteins of normal and diseased human myocardium","volume":"42","author":"Frederiksen, D.W.; Hoffnung, J.M.; Frederiksen, R.T.; Williams, R.B.","year":"1978","unstructured":"Frederiksen DW, Hoffnung JM, Frederiksen RT, Williams RB. The structural proteins of normal and diseased human myocardium. Circ Res 1978;42:459-66.","journal-title":"Circ Res"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/0735-1097(94)90514-2","article-title":"Diagnostic role of echocardiography in constrictive pericarditis","volume":"23","author":"Oh, J.K.; Hatle, L.K.; Seward, J.B.; Danielson, G.K.; Schaff, H.V.; Reeder, G.S.","year":"1994","unstructured":"Oh JK, Hatle LK, Seward JB, Danielson GK, Schaff HV, Reeder GS, et al. Diagnostic role of echocardiography in constrictive pericarditis. J Am Coll Cardiol 1994;23: 154-62.","journal-title":"J Am Coll Cardiol"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0009-8981(67)90167-2","article-title":"Determination of hydroxyproline","volume":"18","author":"Stageman, H.; Stadler, K.","year":"1967","unstructured":"Stageman H, Stadler K. Determination of hydroxyproline. Clin Chim Acta 1967;18:267-73.","journal-title":"Clin Chim Acta"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0003-2697(81)90081-6","article-title":"A simplified method for quantitation of the relative amounts of type I and type m collagen in small tissue samples","volume":"113","author":"Laurent, G.J.; Cockerill, P.; McAnulty, R.J.; Hastings, J.R.B.","year":"1981","unstructured":"Laurent GJ, Cockerill P, McAnulty RJ, Hastings JRB. A simplified method for quantitation of the relative amounts of type I and type m collagen in small tissue samples. Anal Biochem 1981;113:301-12.","journal-title":"Anal Biochem"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1679\/aohc1950.41.267","article-title":"Differential staining of collagens type I, II and III by sirius red polarization microscopy","volume":"41","author":"Junqueira, L.C.U.; Cossermelli, W.; Brentani, R.","year":"1978","unstructured":"Junqueira LCU, Cossermelli W, Brentani R. Differential staining of collagens type I, II and III by sirius red polarization microscopy. Arch Histol3'pn 1978;41:267-74.","journal-title":"Arch Histol3'pn"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/0735-1097(93)90560-N","article-title":"Influence of collagen network on left ventricular systolic and diastolic function in aortic valve disease","volume":"22","author":"Villari, B.; Campbell, S.E.; Hess, O.M.","year":"1993","unstructured":"Villari B, Campbell SE, Hess OM. Influence of collagen network on left ventricular systolic and diastolic function in aortic valve disease. Jf Am Coil Cardiol 1993;22: 1477-84.","journal-title":"Jf Am Coil Cardiol"},{"key":"ref_18","first-page":"277","article-title":"Total pericardiectomy for constricting pericarditis. Early and late results","volume":"5","author":"Stalpaert, G.; Suy, R.; Daenen, W.; Nhevelsteen, A.","year":"1981","unstructured":"Stalpaert G, Suy R, Daenen W, Nhevelsteen A. Total pericardiectomy for constricting pericarditis. Early and late results. Acta Chir Belg 1981;5:277-82.","journal-title":"Acta Chir Belg"},{"key":"ref_19","first-page":"5","article-title":"Constrictive pericarditis with special reference to the change in natural history brought about by surgical intervention","volume":"38","author":"Sommerville, W.","year":"1968","unstructured":"Sommerville W. Constrictive pericarditis with special reference to the change in natural history brought about by surgical intervention. Circulation 1968;38(suppl 5): 102-11.","journal-title":"Circulation"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1001\/archsurg.1964.01320050167017","article-title":"Late results of pericardiectomy. Chronic constrictive pericarditis","volume":"89","author":"Collins, H.A.; Woods, L.P.; Daniel, R.A.","year":"1964","unstructured":"Collins HA, Woods LP, Daniel RA. Late results of pericardiectomy. Chronic constrictive pericarditis. Arch Surg 1964;89:921-28.","journal-title":"Arch Surg"},{"key":"ref_21","first-page":"547","article-title":"Cardiac amyloidosis, constrictive pericarditis, and restrictive cardiomyopathy","volume":"38","author":"Meaney, E.; Shabetai, R.; Bhargava, V.; Shearer, M.; Weidner, C.; Manglardi, L.M.","year":"1956","unstructured":"Meaney E, Shabetai R, Bhargava V, Shearer M, Weidner C, Manglardi LM, et al. Cardiac amyloidosis, constrictive pericarditis, and restrictive cardiomyopathy. Am Jf Cardiol 1956;38:547-56.","journal-title":"Am Jf Cardiol"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1161\/01.CIR.48.6.1268","article-title":"Myocardial fibrosis in constrictive pericarditis. Electrocardiographic and pathologic observations","volume":"48","author":"Levine, H.O.","year":"1973","unstructured":"Levine HO. Myocardial fibrosis in constrictive pericarditis. Electrocardiographic and pathologic observations. Circulation 1973;48: 1268-81.","journal-title":"Circulation"},{"key":"ref_23","first-page":"93","article-title":"Myocardial atrophy in constrictive pericarditis","volume-title":"Mayo Clin Proc 1958","volume":"33","author":"Dines, D.E.; Edwards, J.E.; Burchell, J.B.","unstructured":"Dines DE, Edwards JE, Burchell JB. Myocardial atrophy in constrictive pericarditis. Mayo Clin Proc 1958;33:93-99."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/S0002-8703(41)90409-X","article-title":"The effect of chronic cardiac compression on the size of the heart human fibers","volume":"22","author":"Roberts, J.T.; Beck, C.S.","year":"1941","unstructured":"Roberts JT, Beck CS. The effect of chronic cardiac compression on the size of the heart human fibers. Am HeartJ 1941;22:314-20.","journal-title":"Am HeartJ"},{"key":"ref_25","first-page":"264","article-title":"Surgical treatment of constrictive pericarditis: analysis of outcome and diagnostic error. Circulation 1985; 72(suppl","author":"Seifert, F.C.; Miller, D.C.; Oesterle, S.N.; Oyer, P.E.; Stinson, E.B.; Shumway, N.E.","unstructured":"Seifert FC, Miller DC, Oesterle SN, Oyer PE, Stinson EB, Shumway NE. Surgical treatment of constrictive pericarditis: analysis of outcome and diagnostic error. Circulation 1985;72(suppl II):264-73."},{"key":"ref_26","first-page":"241","article-title":"Myocarditis and myocardial interstitial fibrosis in constrictive pericarditis-an extended pathological spectrum?","volume":"29","author":"Talwar, K.K.; Narula, J.P.; Chopra, P.","year":"1990","unstructured":"Talwar KK, Narula JP, Chopra P. Myocarditis and myocardial interstitial fibrosis in constrictive pericarditis-an extended pathological spectrum? Int 7 Cardiol 1990;29:241-43."},{"key":"ref_27","first-page":"879","article-title":"Analysis of healing after myocardial infarction using polarised light microscopy","volume":"134","author":"Whittaker, P.; Boughner, D.; Kloner, R.","year":"1989","unstructured":"Whittaker P, Boughner D, Kloner R. Analysis of healing after myocardial infarction using polarised light microscopy. Am J Path 1989;134:879-93.","journal-title":"Am J Path"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/0022-2828(90)90079-H","article-title":"Enhanced deposition of predominantly type I collagen in myocardial disease","volume":"22","author":"Greenshop, J.; Greenbaum, R.; Gibson, D.; Yacoub, M.; Laurent, G.","year":"1990","unstructured":"Greenshop J, Greenbaum R, Gibson D, Yacoub M, Laurent G. Enhanced deposition of predominantly type I collagen in myocardial disease. J Mol Cell Cardiol 1990;22:1157-65.","journal-title":"J Mol Cell Cardiol"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1159\/000169525","article-title":"Development of cardiomegaly: a unifying hypothesis explaining the growth of muscle fibers, blood vessels and collagen of heart","volume":"57","author":"Badeer, H.S.","year":"1972","unstructured":"Badeer HS. Development of cardiomegaly: a unifying hypothesis explaining the growth of muscle fibers, blood vessels and collagen of heart. Cardiology 1972;57:247-54.","journal-title":"Cardiology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/0735-1097(89)90360-4","article-title":"Cardiac interstitium in health and disease: the fibrillar collagen network","volume":"3","author":"Weber, K.T.","year":"1989","unstructured":"Weber KT. Cardiac interstitium in health and disease: the fibrillar collagen network. J Am Coll Cardiol 1989;3: 1637-52.","journal-title":"J Am Coll Cardiol"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1161\/01.CIR.83.6.1849","article-title":"Pathological hypertrophy and cardiac interstitium","volume":"83","author":"Weber, K.T.; Brilla, C.G.","year":"1991","unstructured":"Weber KT, Brilla CG. Pathological hypertrophy and cardiac interstitium. Circulation 1991;83:1849-65.","journal-title":"Circulation"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1161\/01.RES.65.2.258","article-title":"Fibrosis induced reduction of the endomyocardium in the rat after isoproterenol treatment","volume":"65","author":"Jalil, J.E.; Janicki, J.S.; Pick, R.; Abrahams, C.; Weber, K.T.","year":"1989","unstructured":"Jalil JE, Janicki JS, Pick R, Abrahams C, Weber KT. Fibrosis induced reduction of the endomyocardium in the rat after isoproterenol treatment. Circ Res 1989;65: 258-64.","journal-title":"Circ Res"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1161\/01.RES.64.6.1041","article-title":"Fibrillar collagen and myocardial stiffness in the intact hypertrophied rat left ventricle","volume":"64","author":"Jalil, J.E.; Doering, C.W.; Janicki, J.S.; Pick, R.; Shroff, S.G.; Weber, K.T.","year":"1989","unstructured":"Jalil JE, Doering CW, Janicki JS, Pick R, Shroff SG, Weber KT. Fibrillar collagen and myocardial stiffness in the intact hypertrophied rat left ventricle. Circ Res 1989;64: 1041-50.","journal-title":"Circ Res"},{"key":"ref_34","first-page":"121","article-title":"Patterns of myocardial fibrosis. J7 Mol Cell Cardiol 1989; 21(suppl V)","author":"Weber, K.T.; Pick, R.; Janin, J.E.; Janicki, J.S.; Carrol, E.P.","unstructured":"Weber KT, Pick R, Janin JE, Janicki JS, Carrol EP. Patterns of myocardial fibrosis. J7 Mol Cell Cardiol 1989; 21(suppl V):121-31."},{"key":"ref_35","first-page":"134","article-title":"Chronic and constrictive pericarditis","author":"Spodick, D.H.","year":"1964","unstructured":"Spodick DH. Chronic and constrictive pericarditis. New York: Grune and Stratton 1964:134-8."},{"key":"ref_36","first-page":"157","article-title":"Hemodynamic determinants of coronary flow: effects of changes in aortic pressure and cardiac output and the relationship between myocardial oxygen consumption and coronary flow","volume":"192","author":"Braunwal, E.; Sarnoff, S.J.; Case, R.B.; Stainsby, W.N.; CH, Jr, Welch","year":"1958","unstructured":"Braunwal E, Sarnoff SJ, Case RB, Stainsby WN, Welch CH Jr. Hemodynamic determinants of coronary flow: effects of changes in aortic pressure and cardiac output and the relationship between myocardial oxygen consumption and coronary flow. Am Jf Physiol 1958;192: 157-63.","journal-title":"Am Jf Physiol"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0033-8389(22)01790-0","article-title":"Radiation-induced heart disease. Clinical and experimental aspects","volume":"9","author":"Stewart, JR, Fajardo; L.F.","year":"1971","unstructured":"Stewart JR, Fajardo LF. Radiation-induced heart disease. Clinical and experimental aspects. Radiol Clin North Am 1971;9:511-31.","journal-title":"Radiol Clin North Am"},{"key":"ref_38","first-page":"552","article-title":"Effect of lactate on collagen proline hydroxylase activity","volume-title":"cultured L-929 fibroblasts. Proc NatlAcad Sci 1970","volume":"66","author":"Comstock, J.P.; Underfrind, S.","unstructured":"Comstock JP, Underfrind S. Effect of lactate on collagen proline hydroxylase activity in cultured L-929 fibroblasts. Proc NatlAcad Sci 1970;66:552-59."}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/hrt.75.2.184","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T07:07:35Z","timestamp":1758438455000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/hrt.75.2.184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,2]]},"references-count":38,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1996,2,1]]},"published-print":{"date-parts":[[1996,2]]}},"alternative-id":["10.1136\/hrt.75.2.184"],"URL":"https:\/\/doi.org\/10.1136\/hrt.75.2.184","relation":{},"ISSN":["1355-6037","1468-201X"],"issn-type":[{"type":"print","value":"1355-6037"},{"type":"electronic","value":"1468-201X"}],"subject":[],"published":{"date-parts":[[1996,2]]}}}