{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:04:16Z","timestamp":1762160656804,"version":"3.44.0"},"reference-count":21,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[1996,3]]},"abstract":"<jats:p>OBJECTIVE: To assess the prognostic value of minor myocardial damage in patients presenting with chest pain without myocardial infarction. DESIGN: The relative risk of suffering a cardiac event in the next six months was assessed in patients with minor myocardial damage assessed by the cardiac markers CK-MB, myoglobin, and troponin T. SETTING: Emergency department of a large university hospital. PATIENTS: In 128 consecutive patients with chest pain, acute myocardial infarction (by WHO criteria) was ruled out; of these, 39 had a rise and fall of one or more markers, indicating minor myocardial damage. The presence of a documented history of coronary artery disease was assessed on admission. RESULTS: 24 patients had a subsequent event (cardiac death, acute myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting) in the next six months. An abnormal troponin T predicted a subsequent event while abnormal CK-MB or myoglobin did not. The relative risk for troponin T was 2.8 (95% confidence interval: 1.0 to 7.9), for myoglobin 1.0 (0.3 to 3.2), and for CK-MB 0.9 (0.2 to 3.4). A documented history of coronary artery disease predicted subsequent events with a relative risk of 3.9 (1.3 to 11.3). CONCLUSIONS: Troponin T was the only marker that predicted future events, but a documented history of coronary artery disease was the best predictor in patients in whom an acute myocardial infarction had been ruled out.<\/jats:p>","DOI":"10.1136\/hrt.75.3.235","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:46:00Z","timestamp":1190137560000},"page":"235-239","source":"Crossref","is-referenced-by-count":53,"title":["Prognostic value of troponin T, myoglobin, and CK-MB mass in patients presenting with chest pain without acute myocardial infarction."],"prefix":"10.1136","volume":"75","author":[{"given":"R. J.","family":"de Winter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. W.","family":"Koster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. H.","family":"Schotveld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Sturk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. P.","family":"van Straalen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. T.","family":"Sanders","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1996,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1161\/01.CIR.88.2.750","article-title":"Biochemical markers of myocardial injury","volume":"88","author":"Adams, J.E.; Abendschein, D.R.; Jaffe, A.S.","year":"1993","unstructured":"Adams JE, Abendschein DR, Jaffe AS. Biochemical markers of myocardial injury. 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Clin Chem 1991;37:1405-11.","journal-title":"Clin Chem"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/clinchem\/37.6.845","article-title":"Cardiac troponin T in diagnosis of acute myocardial infarction","volume":"37","author":"Mair, J.; Artner-Dworzak, E.; Lechleitner, P.","year":"1991","unstructured":"Mair J, Artner-Dworzak E, Lechleitner P, et al. Cardiac troponin T in diagnosis of acute myocardial infarction. Clin Chem 1991;37:845-52.","journal-title":"Clin Chem"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1161\/01.CIR.83.3.902","article-title":"Diagnostic efficiency of troponin T measurements in acute myocardial infarction","volume":"83","author":"Katus, H.A.; Remppis, A.; Neumann, F.J.","year":"1991","unstructured":"Katus HA, Remppis A, Neumann FJ, et al. Diagnostic efficiency of troponin T measurements in acute myocardial infarction. 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Circulation 1989;80:410-14.","journal-title":"Circulation"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1016\/0002-9149(85)90957-9","article-title":"Diagnostic and prognostic significance of minimally elevated creatine kinase-MB in suspected acute myocardial infarction","volume":"55","author":"White, R.D.; Grande, P.; Califf, L.; Palmeri, S.T.; Califf, R.M.; Wagner, G.S.","year":"1985","unstructured":"White RD, Grande P, Califf L, Palmeri ST, Califf RM, Wagner GS. Diagnostic and prognostic significance of minimally elevated creatine kinase-MB in suspected acute myocardial infarction. Am J7 Cardiol 1985;55: 1478-84.","journal-title":"Am J7 Cardiol"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0002-9149(87)90793-4","article-title":"Significance of elevated MB isoenzyme with normal creatine kinase in acute myocardial infarction","volume":"59","author":"Yusuf, S.; Collins, R.; Lin, L.; Sterry, H.; Pearson, M.; Sleight, P.","year":"1987","unstructured":"Yusuf S, Collins R, Lin L, Sterry H, Pearson M, Sleight P. Significance of elevated MB isoenzyme with normal creatine kinase in acute myocardial infarction. Am J Cardiol 1987;59:245-50.","journal-title":"Am J Cardiol"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0009-8981(85)90281-5","article-title":"Semi-quantitative estimation of serum myoglobin by a rapid latex agglutination method: an emergency screening test for acute myocardial infarction","volume":"145","author":"Chapelle, J.P.; Heusgem, C.","year":"1985","unstructured":"Chapelle JP, Heusgem C. Semi-quantitative estimation of serum myoglobin by a rapid latex agglutination method: an emergency screening test for acute myocardial infarction. Clin Chim Acta 1985;145:143-50.","journal-title":"Clin Chim Acta"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"221","DOI":"10.7326\/0003-4819-105-2-221","article-title":"Serum enzyme assays in the diagnosis of acute myocardial infarction","volume":"105","author":"Lee, T.H.; Goldman, L.","year":"1986","unstructured":"Lee TH, Goldman L. 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Arch Intern Med 1988;148:1762-5.","journal-title":"Arch Intern Med"},{"key":"ref_18","first-page":"122","article-title":"Serum myoglobin determinations in the assessment of myocardial infarction","volume-title":"Eur Heart Y","volume":"3","author":"Chapelle, J.P.; Albert, A.; Smeets, J.P.; Boland, J.; Heusgem, C.; Kulbertus, H.E.","year":"1982","unstructured":"Chapelle JP, Albert A, Smeets JP, Boland J, Heusgem C, Kulbertus HE. Serum myoglobin determinations in the assessment of myocardial infarction. Eur Heart Y 1982;3: 122-9."},{"key":"ref_19","first-page":"45","article-title":"Troponin T and myoglobin at admission: value of early diagnosis of acute myocardial infarction","volume":"7","author":"Bakker, A.J.; Koelemay, M.J.W.; Gorgels, J.P.M.C.","year":"1994","unstructured":"Bakker AJ, Koelemay MJW, Gorgels JPMC, et al. Troponin T and myoglobin at admission: value of early diagnosis of acute myocardial infarction. Eur Heart _7 1994;15:45-53.","journal-title":"Eur Heart"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/S0735-1097(85)80216-3","article-title":"Creatine kinase release not associated with myocardial necrosis after short periods of coronary artery occlusion in conscious baboons","volume":"6","author":"Heyndrickx, G.R.; Amano, J.; Kenna, R.","year":"1985","unstructured":"Heyndrickx GR, Amano J, Kenna R, et al. Creatine kinase release not associated with myocardial necrosis after short periods of coronary artery occlusion in conscious baboons. _JAm Coll Cardiol 1985;6:1299-303.","journal-title":"_JAm Coll Cardiol"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0022-2828(84)80609-4","article-title":"Early enzyme release from myocardial cells is not due to irreversible cell damage","volume":"16","author":"Piper, H.M.; Schwarz, P.; Spahr, R.; Hutter, J.F.; Spieckermann, P.G.","year":"1984","unstructured":"Piper HM, Schwarz P, Spahr R, Hutter JF, Spieckermann PG. 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