{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T10:31:01Z","timestamp":1764239461648,"version":"build-2065373602"},"reference-count":45,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[1996,3]]},"abstract":"<jats:p>OBJECTIVE: To study the effect of transdermal scopolamine on heart rate variability, baroreflex sensitivity, and exercise performance in patients with heart failure and age matched healthy volunteers. DESIGN: Double blind, randomised, placebo controlled, crossover study. PATIENTS: 16 patients with chronic, stable heart failure due to ischaemic cardiomyopathy (mean (SEM) age 58 (2) years; mean (SEM) radionuclide left ventricular ejection fraction 28 (2)%; New York Heart Association class II-III) and eight age matched healthy controls. INTERVENTION: Transdermal scopolamine (500 micrograms delivered over 72 h) or a placebo patch was administered for 48 h. MAIN OUTCOME MEASURES: Indices of tonic and reflex cardiac vagal activity and exercise performance. RESULTS: In both groups scopolamine produced a reduction in the 24 h average heart rate and an increase in the time domain measures of heart rate variability. Both the incidence and severity of ventricular arrhythmias remained unchanged. Baroreflex sensitivity, evaluated by the phenylephrine technique, increased significantly (P &lt; 0.001) with scopolamine in patients with heart failure (6.22 (2.81) ms\/mm Hg) and in healthy volunteers (5.97 (2.20) ms\/mm Hg) as did the amplitude of respiratory sinus arrhythmia, computed by autoregressive spectral analysis of 10 min electrocardiographic recordings (319.9 (123.5) and 657.3 (126.6) ms2 respectively, P &lt; 0.001). While exercise performance did not change, heart rate at submaximal exercise was significantly reduced by scopolamine in each group. CONCLUSIONS: In patients with mild to moderate heart failure low doses of scopolamine increased tonic and reflex cardiac vagal activity. This was achieved without affecting exercise tolerance or the incidence and severity of ventricular arrhythmias.<\/jats:p>","DOI":"10.1136\/hrt.75.3.274","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:46:00Z","timestamp":1190137560000},"page":"274-280","source":"Crossref","is-referenced-by-count":31,"title":["Effect of low doses of scopolamine on RR interval variability, baroreflex sensitivity, and exercise performance in patients with chronic heart failure."],"prefix":"10.1136","volume":"75","author":[{"given":"B.","family":"Casadei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Conway","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Forfar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Sleight","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1996,3,1]]},"reference":[{"key":"ref_1","first-page":"40","article-title":"Plasma norepinephrine, plasma renin activity, and congestive heart failure. 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Med J7 Aust 1978;2:52."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1161\/01.CIR.78.4.816","article-title":"Baroreflex sensitivity, clinical correlates, and cardiovascular mortality among patients with a first myocardial infarction: a prospective study","volume":"78","author":"MT, La Rovere; G, Specchia; A, Mortara; PJ, Schwartz","year":"1988","unstructured":"La Rovere MT, Specchia G, Mortara A, Schwartz PJ. Baroreflex sensitivity, clinical correlates, and cardiovascular mortality among patients with a first myocardial infarction: a prospective study. Circulation 1988;78: 816-24.","journal-title":"Circulation"},{"key":"ref_4","first-page":"1","article-title":"and interpretation of randomized, controlled trials in congestive heart failure and left ventricular dysfunction","volume":"87","author":"Yusuf, S.; Design, Garg R.; results","year":"1993","unstructured":"Yusuf S, Garg R. 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Am Jf Physiol 1989;256:H 142-52.","journal-title":"Am Jf Physiol"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1042\/cs0870649","article-title":"Low-frequency spontaneous fluctuations of R-R interval and blood pressure in conscious humans: a baroreceptor or central phenomenon?","volume":"87","author":"Bemardi, L.; Leuzzi, S.; Radaelli, A.; Passino, C.; Johnston, J.A.; Sleight, P.","year":"1994","unstructured":"Bemardi L, Leuzzi S, Radaelli A, Passino C, Johnston JA, Sleight P. Low-frequency spontaneous fluctuations of R-R interval and blood pressure in conscious humans: a baroreceptor or central phenomenon? Clin Sci 1994;87: 649-54.","journal-title":"Clin Sci"},{"issue":"24","key":"ref_24","first-page":"109","article-title":"Reflex regulation of arterial pressure during sleep in man: a quantitative method of assessing baroreflex sensitivity","volume":"1969","author":"Smyth, H.S.; Sleight, P.; Pickering, G.W.","unstructured":"Smyth HS, Sleight P, Pickering GW. Reflex regulation of arterial pressure during sleep in man: a quantitative method of assessing baroreflex sensitivity. Circ Res 1969; 24: 109-21.","journal-title":"Circ Res"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1365-2125.1979.tb05903.x","article-title":"The two-period cross-over clinical trial","volume":"8","author":"Hills, M.; Armitage, P.","year":"1979","unstructured":"Hills M, Armitage P. The two-period cross-over clinical trial. BrJ Clin Pharmacol 1979;8:7-20.","journal-title":"BrJ Clin Pharmacol"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/0002-9149(87)90601-1","article-title":"Heart rate variability as an index of sympathovagal interaction after acute myocardial infarction","volume":"60","author":"Lombardi, F.; Sandrone, G.; Pernpruner, S.; Sala, R.; Garimoldi, M.; Cerutti, S.","year":"1987","unstructured":"Lombardi F, Sandrone G, Pernpruner S, Sala R, Garimoldi M, Cerutti S, et al. Heart rate variability as an index of sympathovagal interaction after acute myocardial infarction. Am Jf Cardiol 1987;60:1239-45.","journal-title":"Am Jf Cardiol"},{"issue":"146-5","key":"ref_27","first-page":"1","article-title":"Opposing central and peripheral effects of atropine on parasympathetic cardiac control","volume":"232","author":"Katona, P.G.; Lipson, D.; Dauchot, P.J.","year":"1977","unstructured":"Katona PG, Lipson D, Dauchot PJ. 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Decreased heart rate variability and its association with increased mortality after acute myocardial infarction","volume":"59","author":"Kleiger, R.E.; Miller, J.P.; JT, Jr, Bigger; Moss, A.J.","year":"1987","unstructured":"Kleiger RE, Miller JP, Bigger JT Jr, Moss AJ, and the Multicenter Post Infarction Research Group. Decreased heart rate variability and its association with increased mortality after acute myocardial infarction. Am J Cardiol 1987;59:256-62.","journal-title":"Am J Cardiol"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1136\/hrt.34.9.901","article-title":"Sinus rate in acute myocardial infarction","volume":"34","author":"Norris, R.M.; Mercer, C.J.; Yeates, S.E.","year":"1972","unstructured":"Norris RM, Mercer CJ, Yeates SE. Sinus rate in acute myocardial infarction. 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