{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:23:26Z","timestamp":1760783006201,"version":"3.44.0"},"reference-count":17,"publisher":"BMJ","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Heart"],"published-print":{"date-parts":[[1996,8]]},"abstract":"<jats:p>OBJECTIVES: To assess the value of dobutamine stress echocardiography (DSE) in the prediction of the extent and location of coronary artery stenosis in symptomatic patients with old myocardial infarction and to study the impact of the severity of resting wall motion abnormalities (WMA) on the diagnostic accuracy of the test. PATIENTS: One hundred and thirty two symptomatic patients with old myocardial infarction. METHODS: DSE (up to 40 micrograms\/kg\/min, with atropine up to 1 mg) was performed in all patients. Ischaemia was defined as new or worsened WMA. For each coronary artery, regional wall motion in the corresponding territory was classified as normal, mildly, moderately, or severely impaired according to the wall motion score index. Significant coronary stenosis was defined as &gt; or = 50% diameter stenosis. RESULTS: A positive DSE for ischaemia occurred in 87 of 111 patients with and three of 21 patients without coronary artery stenosis (sensitivity = 78%; CI 71 to 86, specificity = 86%; CI 79 to 92, accuracy = 80%; CI 73 to 87). The accuracy for the diagnosis of individual coronary stenosis was 69% in the presence of normal wall motion and 74%, 74%, and 61% respectively when there was mild, moderate, and severe WMA in the corresponding territories (P = NS). The sensitivity was higher in presence of mild or moderate WMA (73%) than with normal wall motion (53%) or severe WMA (56%, P &lt; 0.05 in both). In territories subtended by a stenotic artery, the regional wall motion score index was not different with or without ischaemia. CONCLUSION: DSE had a good overall accuracy for the diagnosis of coronary artery stenosis in symptomatic patients with old myocardial infarction. The presence of resting WMA did not limit DSE as a method of eliciting myocardial ischaemia and diagnosing significant coronary artery stenosis in patients with old myocardial infarctions.<\/jats:p>","DOI":"10.1136\/hrt.76.2.123","type":"journal-article","created":{"date-parts":[[2007,9,18]],"date-time":"2007-09-18T17:46:00Z","timestamp":1190137560000},"page":"123-128","source":"Crossref","is-referenced-by-count":22,"title":["Accuracy of dobutamine stress echocardiography for the diagnosis of coronary artery stenosis in patients with myocardial infarction: the impact of extent and severity of left ventricular dysfunction."],"prefix":"10.1136","volume":"76","author":[{"given":"A.","family":"Elhendy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. T.","family":"yan Domburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. R.","family":"Roelandt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. L.","family":"Geleijnse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. H.","family":"Cornel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. M.","family":"el-Said","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. M.","family":"Fioretti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1996,8,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0002-9149(87)90975-1","article-title":"Usefulness of residual ischemic myocardium within prior infarct zone for identifying patients at high risk late after acute myocardial infarction","volume":"60","author":"Brown, K.A.; Weiss, R.M.; Clements, J.P.; Wackers, F.J.I.T.","year":"1987","unstructured":"Brown KA, Weiss RM, Clements JP, Wackers FJIT. Usefulness of residual ischemic myocardium within prior infarct zone for identifying patients at high risk late after acute myocardial infarction. 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Am J Cardiol 1994;73:896-8.","journal-title":"Am J Cardiol"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/0735-1097(94)90388-3","article-title":"Quantitative coronary angiography in the estimation of the functional significance of coronary stenosis: correlation with dobutamine-atropine stress test","volume":"23","author":"Baptista, J.; Amese, M.; Roelandt, J.R.T.C.; Fioretti, P.; Keane, D.; Escaned, J.","year":"1994","unstructured":"Baptista J, Amese M, Roelandt JRTC, Fioretti P, Keane D, Escaned J, et al. Quantitative coronary angiography in the estimation of the functional significance of coronary stenosis: correlation with dobutamine-atropine stress test. 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The stunned myocardium: prolonged, postischemic ventricular dysfunction. Circulation 1982;66:1 146-9.","journal-title":"Circulation"},{"key":"ref_16","first-page":"18","article-title":"Stress echocardiography: comparison of exercise, dipyridamole and dobutamine in detecting and predicting the extent of coronary artery disease","volume":"62","author":"Dagianti, A.; Penco, M.; Agati, L.; Sciomer, S.; Dagianti, A.; Rosanio, S.","year":"1995","unstructured":"Dagianti A, Penco M, Agati L, Sciomer S, Dagianti A, Rosanio S, et al. Stress echocardiography: comparison of exercise, dipyridamole and dobutamine in detecting and predicting the extent of coronary artery disease. 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Circulation 1994;90-I452.","journal-title":"Circulation"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/hrt.76.2.123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T12:13:26Z","timestamp":1758370406000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/hrt.76.2.123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,8]]},"references-count":17,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1996,8,1]]},"published-print":{"date-parts":[[1996,8]]}},"alternative-id":["10.1136\/hrt.76.2.123"],"URL":"https:\/\/doi.org\/10.1136\/hrt.76.2.123","relation":{},"ISSN":["1355-6037","1468-201X"],"issn-type":[{"type":"print","value":"1355-6037"},{"type":"electronic","value":"1468-201X"}],"subject":[],"published":{"date-parts":[[1996,8]]}}}