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Disopyramide was effective in preventing ventricular fibrillation during EPS. \u03b2 Adrenoceptor stimulation manifested bifid T waves and reduced ST segment elevation in right precordial leads. Simultaneously recorded monophasic action potential (MAP) duration at 90% repolarisation did not change in the right ventricular outflow tract, while it shortened in the left ventricular septum. These findings suggest that right precordial bifid T waves might result from relatively early repolarisation of the left ventricles. Moreover the gradient of action potential duration might explain the mechanism of ST segment abnormalities in a patient with Brugada syndrome.<\/jats:p>","DOI":"10.1136\/hrt.79.3.305","type":"journal-article","created":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T15:31:45Z","timestamp":1413991905000},"page":"305-307","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Bifid T waves induced by isoprenaline in a patient with Brugada syndrome"],"prefix":"10.1136","volume":"79","author":[{"given":"T","family":"Washizuka","sequence":"first","affiliation":[{"name":"First Department of Internal Medicine, Niigata University School of Medicine, Asahimachi 1\u2013754, Niigata 951, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Chinushi","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Niigata University School of Medicine, Asahimachi 1\u2013754, Niigata 951, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Niwano","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Niigata University School of Medicine, Asahimachi 1\u2013754, Niigata 951, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Aizawa","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Niigata University School of Medicine, Asahimachi 1\u2013754, Niigata 951, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1998,3,1]]},"reference":[{"key":"2025092006394384000_79.3.305.1","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/0735-1097(92)90253-J","article-title":"Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome.","volume":"20","author":"Brugada","year":"1992","journal-title":"Am J Cardiol"},{"key":"2025092006394384000_79.3.305.2","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1111\/j.1540-8159.1996.tb03389.x","article-title":"Electrophysiological findings in idiopathic recurrent ventricular fibrillation: Special reference to mode of induction, drug testing, and long-term outcomes.","volume":"19","author":"Aizawa","year":"1996","journal-title":"PACE"},{"doi-asserted-by":"publisher","key":"2025092006394384000_79.3.305.3","DOI":"10.1111\/j.1540-8167.1993.tb01236.x"},{"doi-asserted-by":"publisher","key":"2025092006394384000_79.3.305.4","DOI":"10.1136\/hrt.52.2.207"},{"doi-asserted-by":"publisher","key":"2025092006394384000_79.3.305.5","DOI":"10.1016\/0735-1097(95)00613-3"},{"doi-asserted-by":"publisher","key":"2025092006394384000_79.3.305.6","DOI":"10.1016\/0002-8703(79)90434-4"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/hrt.79.3.305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T13:39:51Z","timestamp":1758375591000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/hrt.79.3.305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,3,1]]},"references-count":6,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1998,3,1]]},"published-print":{"date-parts":[[1998,3,1]]}},"alternative-id":["10.1136\/hrt.79.3.305"],"URL":"https:\/\/doi.org\/10.1136\/hrt.79.3.305","relation":{},"ISSN":["1355-6037","1468-201X"],"issn-type":[{"type":"print","value":"1355-6037"},{"type":"electronic","value":"1468-201X"}],"subject":[],"published":{"date-parts":[[1998,3,1]]}}}