{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T22:25:42Z","timestamp":1770071142781,"version":"3.49.0"},"reference-count":15,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Heart"],"accepted":{"date-parts":[[1997,12,15]]},"published-print":{"date-parts":[[1998,8,1]]},"abstract":"<jats:p>The symptomatic presentation of an unruptured sinus of Valsalva aneurysm is rare. A 48 year old man with a history of treated hypothyroidism, and a five year history of ileocolonic Crohn\u2019s disease of chronic low grade activity presented with a profound left hemiplegia. He was in sinus rhythm and normotensive. Cardiac auscultation was repeatedly normal. Computed tomography of the head performed early in the course of the illness was reported as normal. Duplex Doppler examination of the carotid arteries performed six months later revealed no significant atheroma. There was complete resolution of the neurological deficit over a period of months. A year later he presented with chest pain suggestive of myocardial ischaemia. Computed tomography, magnetic resonance imaging, transthoracic and transoesophageal echocardiography, and cardiac catheterisation pointed to a sinus of Valsalva aneurysm protruding into the left ventricular outflow tract. In view of the previous neurological event and ongoing chest pain suggestive of myocardial ischaemia, the lesion was resected. The patient made a good recovery and postoperative transoesophageal echocardiography showed normal aortic valve function with no residual regurgitation. This is the first reported case of pure left ventricular outflow tract extension of an unruptured left sinus aneurysm. The presentation with ischaemic cardiac pain does not seem to be explained by conventional mechanisms.<\/jats:p>","DOI":"10.1136\/hrt.80.2.190","type":"journal-article","created":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T15:31:45Z","timestamp":1413991905000},"page":"190-193","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Unruptured aneurysm of the left sinus of Valsalva extending into the left ventricular outflow tract: presentation and imaging"],"prefix":"10.1136","volume":"80","author":[{"given":"C","family":"Pepper","sequence":"first","affiliation":[{"name":"aDepartment of Cardiology, York District Hospital, Wigginton Road, York YO3 7HE, UK, \n\nbDepartment of Cardiothoracic Surgery, Yorkshire Heart Centre, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK, \n\ncDepartment of Radiology, Yorkshire Heart Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Munsch","sequence":"additional","affiliation":[{"name":"aDepartment of Cardiology, York District Hospital, Wigginton Road, York YO3 7HE, UK, \n\nbDepartment of Cardiothoracic Surgery, Yorkshire Heart Centre, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK, \n\ncDepartment of Radiology, Yorkshire Heart Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U M","family":"Sivananthan","sequence":"additional","affiliation":[{"name":"aDepartment of Cardiology, York District Hospital, Wigginton Road, York YO3 7HE, UK, \n\nbDepartment of Cardiothoracic Surgery, Yorkshire Heart Centre, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK, \n\ncDepartment of Radiology, Yorkshire Heart Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Pye","sequence":"additional","affiliation":[{"name":"aDepartment of Cardiology, York District Hospital, Wigginton Road, York YO3 7HE, UK, \n\nbDepartment of Cardiothoracic Surgery, Yorkshire Heart Centre, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK, \n\ncDepartment of Radiology, Yorkshire Heart Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1998,8,1]]},"reference":[{"key":"2025101723475199000_80.2.190.1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1136\/thx.12.2.125","article-title":"The pathologic anatomy of deficiencies between the aortic root and the heart including aortic sinus aneurysms.","volume":"12","author":"Edwards","year":"1957","journal-title":"Thorax"},{"key":"2025101723475199000_80.2.190.2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(93)90709-I"},{"key":"2025101723475199000_80.2.190.3","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.61.4.375"},{"key":"2025101723475199000_80.2.190.4","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(90)90714-C"},{"key":"2025101723475199000_80.2.190.5","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1093\/oxfordjournals.eurheartj.a061811","article-title":"Sinus of Valsalva aneurysm obstructing coronary arterial flow: case report and collective review of the literature.","volume":"6","author":"Brandt","year":"1985","journal-title":"Eur Heart J"},{"key":"2025101723475199000_80.2.190.6","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(84)90846-9"},{"key":"2025101723475199000_80.2.190.7","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.53.2.226"},{"key":"2025101723475199000_80.2.190.8","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S0022-5223(19)40117-7","article-title":"Congenital aneurysm of the sinus of Valsalva protruding into the left ventricle.","volume":"71","author":"Heydorn","year":"1976","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2025101723475199000_80.2.190.9","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(94)90256-9"},{"key":"2025101723475199000_80.2.190.10","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1093\/oxfordjournals.eurheartj.a062473","article-title":"Unruptured aneurysm of the sinus of Valsalva presenting with ventricular tachycardia.","volume":"9","author":"Channer","year":"1988","journal-title":"Eur Heart J"},{"key":"2025101723475199000_80.2.190.11","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/S0735-1097(86)80519-8","article-title":"Unruptured sinus of Valsalva aneurysm with right ventricular outflow obstruction diagnosed by two dimensional and Doppler echocardiography.","volume":"7","author":"Kiefaber","year":"1986","journal-title":"J Am Coll Cardiol"},{"key":"2025101723475199000_80.2.190.12","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(85)90608-8"},{"key":"2025101723475199000_80.2.190.13","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.54.4.442"},{"key":"2025101723475199000_80.2.190.14","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1161\/01.STR.27.8.1424","article-title":"Aneurysm of the left sinus of Valsalva. An unusual source of cerebral embolism.","volume":"27","author":"St\u00f6lberger","year":"1996","journal-title":"Stroke"},{"key":"2025101723475199000_80.2.190.15","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(90)90188-4"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/hrt.80.2.190","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T06:47:57Z","timestamp":1760770077000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/hrt.80.2.190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,8,1]]},"references-count":15,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1998,8,1]]},"published-print":{"date-parts":[[1998,8,1]]}},"alternative-id":["10.1136\/hrt.80.2.190"],"URL":"https:\/\/doi.org\/10.1136\/hrt.80.2.190","relation":{},"ISSN":["1355-6037","1468-201X"],"issn-type":[{"value":"1355-6037","type":"print"},{"value":"1468-201X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,8,1]]}}}