{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:07:08Z","timestamp":1765609628856,"version":"3.44.0"},"reference-count":39,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Heart"],"accepted":{"date-parts":[[1998,4,24]]},"published-print":{"date-parts":[[1998,9,1]]},"abstract":"<jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>To compare the clinical and morphological characteristics of patients with<jats:italic>Streptococcus bovis<\/jats:italic> endocarditis with those of patients with endocarditis caused by other microorganisms.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec sec-type=\"methods\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>177 consecutive patients (<jats:italic>Streptococcus bovis<\/jats:italic>, 22; other s<jats:italic>treptococci<\/jats:italic>, 94;<jats:italic>staphylococci<\/jats:italic>, 44; other, 17) with definite infective endocarditis according to the Duke criteria were included. All patients underwent transthoracic and transoesophageal echocardiography. In 88 patients, findings from surgery\/necropsy were obtained.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>S bovis endocarditis was associated with older patients, with a higher mortality (p\u2009=\u20090.04), and with a higher rate of cardiac surgery (p\u2009&lt;\u20090.001) than other microorganisms, although embolic events were observed less often (p\u2009=\u20090.02). Pathological gastrointestinal lesions were detected in 45% of the patients. Multiple valves were affected in 68% of the patients with<jats:italic>S bovis<\/jats:italic> endocarditis and in 20% of those with other organisms (p\u2009&lt;\u20090.001). Moderate or severe regurgitation occurred more often in <jats:italic>S bovis <\/jats:italic>endocarditis than with other microorganisms (p\u2009=\u20090.05). When surgery or necropsy was performed, infectious myocardial infiltration of the left ventricle was confirmed histopathologically in 36% of the patients with<jats:italic>S bovis<\/jats:italic> endocarditis and in 10% of those with other organisms (p\u2009=\u20090.002).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>S bovis endocarditis is a severe illness because of the more common involvement of multiple valves, and of the frequent occurrence of haemodynamically relevant valvar regurgitation and infectious myocardial infiltration.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/hrt.80.3.276","type":"journal-article","created":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T15:31:45Z","timestamp":1413991905000},"page":"276-280","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":86,"title":["Clinical and morphological characteristics in<i>Streptococcus bovis<\/i> endocarditis: a comparison with other causative microorganisms in 177 cases"],"prefix":"10.1136","volume":"80","author":[{"given":"I","family":"Kupferwasser","sequence":"first","affiliation":[{"name":"aDepartment of Medicine II, Mainz University, Mainz, Germany, \n\nbDepartment of Pathology, Mainz University, \n\ncDepartment of Biostatistics, Mainz University, \n\ndDepartment of Cardiothoracic and Vascular Surgery, Mainz University, \n\neDivision of Cardiology, University of Essen, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Darius","sequence":"additional","affiliation":[{"name":"aDepartment of Medicine II, Mainz University, Mainz, Germany, \n\nbDepartment of Pathology, Mainz University, \n\ncDepartment of Biostatistics, Mainz University, \n\ndDepartment of Cardiothoracic and Vascular Surgery, Mainz University, \n\neDivision of Cardiology, University of Essen, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A M","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"aDepartment of Medicine II, Mainz University, Mainz, Germany, \n\nbDepartment of Pathology, Mainz University, \n\ncDepartment of Biostatistics, Mainz University, \n\ndDepartment of Cardiothoracic and Vascular Surgery, Mainz University, \n\neDivision of Cardiology, University of Essen, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Mohr-Kahaly","sequence":"additional","affiliation":[{"name":"aDepartment of Medicine II, Mainz University, Mainz, Germany, \n\nbDepartment of Pathology, Mainz University, \n\ncDepartment of Biostatistics, Mainz University, \n\ndDepartment of Cardiothoracic and Vascular Surgery, Mainz University, \n\neDivision of Cardiology, University of Essen, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Westermeier","sequence":"additional","affiliation":[{"name":"aDepartment of Medicine II, Mainz University, Mainz, Germany, \n\nbDepartment of Pathology, Mainz University, \n\ncDepartment of Biostatistics, Mainz University, \n\ndDepartment of Cardiothoracic and Vascular Surgery, Mainz University, \n\neDivision of Cardiology, University of Essen, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Oelert","sequence":"additional","affiliation":[{"name":"aDepartment of Medicine II, Mainz University, Mainz, Germany, \n\nbDepartment of Pathology, Mainz University, \n\ncDepartment of Biostatistics, Mainz University, \n\ndDepartment of Cardiothoracic and Vascular Surgery, Mainz University, \n\neDivision of Cardiology, University of Essen, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Erbel","sequence":"additional","affiliation":[{"name":"aDepartment of Medicine II, Mainz University, Mainz, Germany, \n\nbDepartment of Pathology, Mainz University, \n\ncDepartment of Biostatistics, Mainz University, \n\ndDepartment of Cardiothoracic and Vascular Surgery, Mainz University, \n\neDivision of Cardiology, University of Essen, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Meyer","sequence":"additional","affiliation":[{"name":"aDepartment of Medicine II, Mainz University, Mainz, Germany, \n\nbDepartment of Pathology, Mainz University, \n\ncDepartment of Biostatistics, Mainz University, \n\ndDepartment of Cardiothoracic and Vascular Surgery, Mainz University, \n\neDivision of Cardiology, University of Essen, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1998,9,1]]},"reference":[{"key":"2025092021492695000_80.3.276.1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90890-4"},{"key":"2025092021492695000_80.3.276.2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)90885-G"},{"key":"2025092021492695000_80.3.276.3","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1982.00340170145023"},{"key":"2025092021492695000_80.3.276.4","doi-asserted-by":"crossref","unstructured":"Kaye D. Changing pattern of infective endocarditis.Am J Med1985;78(suppl 6B):157\u201362.","DOI":"10.1016\/0002-9343(85)90378-X"},{"key":"2025092021492695000_80.3.276.5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197710132971503"},{"key":"2025092021492695000_80.3.276.6","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1001\/archinte.1978.03630320037013","article-title":"Streptococcus bovis bacteremia and underlying gastrointestinal disease.","volume":"138","author":"Murray","year":"1978","journal-title":"Arch Intern Med"},{"key":"2025092021492695000_80.3.276.7","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/19.2.361"},{"key":"2025092021492695000_80.3.276.8","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(88)90173-1"},{"key":"2025092021492695000_80.3.276.9","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1056\/NEJM197712152972421","article-title":"Streptococcus bovis endocarditis with carcinoma of the colon [letter].","volume":"297","author":"Steinberg","year":"1977","journal-title":"N Engl J Med"},{"key":"2025092021492695000_80.3.276.10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)92652-1"},{"key":"2025092021492695000_80.3.276.11","first-page":"7012","article-title":"Streptococcus bovis as the cause of combined endocarditis of the aortic, mitral and tricuspid valves.","volume":"157","author":"Friis","year":"1995","journal-title":"Ugeskr\u2013Laegr"},{"key":"2025092021492695000_80.3.276.12","doi-asserted-by":"publisher","DOI":"10.1007\/BF01641351"},{"key":"2025092021492695000_80.3.276.13","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/ehj\/9.1.43","article-title":"Improved diagnostic value of echocardiography in patients with infective endocarditis by transesophageal approach. A prospective study.","volume":"9","author":"Erbel","year":"1988","journal-title":"Eur Heart J"},{"key":"2025092021492695000_80.3.276.14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199103213241203"},{"key":"2025092021492695000_80.3.276.15","doi-asserted-by":"crossref","unstructured":"Daniel WG, Schr\u00f6der E, Nonnast-Daniel B,et al. Conventional and transesophageal echocardiography in the diagnosis of infective endocarditis.Eur Heart J1987;8(suppl J):287\u201392.","DOI":"10.1093\/eurheartj\/8.suppl_J.287"},{"key":"2025092021492695000_80.3.276.16","doi-asserted-by":"publisher","DOI":"10.1378\/chest.105.2.377"},{"key":"2025092021492695000_80.3.276.17","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)80719-X"},{"key":"2025092021492695000_80.3.276.18","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1093\/oxfordjournals.eurheartj.a060961","article-title":"Identification of high-risk subgroups in infective endocarditis and the role of echocardiography.","volume":"16","author":"Erbel","year":"1995","journal-title":"Eur Heart J"},{"key":"2025092021492695000_80.3.276.19","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(94)90143-0"},{"key":"2025092021492695000_80.3.276.20","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.75.1.175"},{"key":"2025092021492695000_80.3.276.21","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(86)90619-3"},{"key":"2025092021492695000_80.3.276.22","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/0735-1097(92)90612-Q","article-title":"Quantitation of mitral regurgitation by transesophageal echocardiography with Doppler color flow mapping: correlation with cardiac catheterization.","volume":"19","author":"Castello","year":"1992","journal-title":"J Am Coll Cardiol"},{"key":"2025092021492695000_80.3.276.23","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1161\/01.CIR.85.4.1237","article-title":"Evaluation of biplane color Doppler transesophageal echocardiography in 200 consecutive patients.","volume":"85","author":"Omoto","year":"1992","journal-title":"Circulation"},{"key":"2025092021492695000_80.3.276.24","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(87)80254-1"},{"key":"2025092021492695000_80.3.276.25","doi-asserted-by":"publisher","DOI":"10.2307\/2281868"},{"key":"2025092021492695000_80.3.276.26","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1093\/oxfordjournals.eurheartj.a060923","article-title":"Characteristics of infective endocarditis in France in 1991. 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Report of 10 cases.","volume":"39","author":"Oumeskour","year":"1990","journal-title":"Ann Cardiol Angeiol Paris"},{"key":"2025092021492695000_80.3.276.36","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(91)80159-J"},{"key":"2025092021492695000_80.3.276.37","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1056\/NEJM197803092981014","article-title":"More on Streptococcus bovis endocarditis and bowel carcinoma.","volume":"298","author":"Brooks","year":"1978","journal-title":"N Engl J Med"},{"key":"2025092021492695000_80.3.276.38","doi-asserted-by":"crossref","first-page":"572","DOI":"10.7326\/0003-4819-118-7-199304010-00026","article-title":"Significance of Streptococcus bovis endocarditis [letter].","volume":"118","author":"Tornos","year":"1993","journal-title":"Ann Intern Med"},{"key":"2025092021492695000_80.3.276.39","first-page":"162","article-title":"Carcinoma of the colon 2 years after endocarditis due to Streptococcus bovis.","volume":"78","author":"Robbins","year":"1983","journal-title":"Am J Gastroenterol"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/hrt.80.3.276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T04:49:35Z","timestamp":1758430175000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/hrt.80.3.276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,9,1]]},"references-count":39,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1998,9,1]]},"published-print":{"date-parts":[[1998,9,1]]}},"alternative-id":["10.1136\/hrt.80.3.276"],"URL":"https:\/\/doi.org\/10.1136\/hrt.80.3.276","relation":{},"ISSN":["1355-6037","1468-201X"],"issn-type":[{"type":"print","value":"1355-6037"},{"type":"electronic","value":"1468-201X"}],"subject":[],"published":{"date-parts":[[1998,9,1]]}}}