{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T10:54:56Z","timestamp":1774954496906,"version":"3.50.1"},"reference-count":31,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Heart"],"accepted":{"date-parts":[[1998,6,24]]},"published-print":{"date-parts":[[1998,11,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To investigate the safety, efficacy, and clinical application of a new self centring device (\u201cangel wings\u201d) for closure of secundum atrial septal defects (ASD II) and persistent foramen ovale in all age groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Multicentre, prospective, non-randomised study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients<\/jats:title>\n                  <jats:p>Inclusion criteria: defects with an occlusive diameter of \u2a7d\u200920 mm and a surrounding rim of &gt;\u20094 mm; body weight &gt;\u200910\u2009kg; and an indication for surgical closure of secundum atrial septal defect. Additionally, there were compassionate indications for closure in patients with persistent foramen ovale.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Interventions<\/jats:title>\n                  <jats:p>Defects were closed by a transcatheter device consisting of two square frames made of superelastic nitinol wire. The frames are covered by elastic polyester fabric, which is sewn together at a central circle. All procedures, except for three interventions that were carried out under sedation, were performed under general anaesthesia using transoesophageal echocardiography and fluoroscopy to monitor intervention.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Closure was attempted in 75 (71%) of 105 patients. An ASD II was present in 35 children and 15 adults. A persistent foramen ovale was present in 25 adults with suspected paradoxical embolism. Transcatheter closure was unsuccessful in three children and crossover to surgery was required. Residual shunts were found in 20 patients (27%) immediately after the procedure. A transient atrioventricular third degree block occurred in three patients (4%) and the right atrial disk was not fully deployed in three. A minor shunt (&lt;\u20093\u2009mm) was present in only three (4%) of 72 patients during follow up of 1\u201317 months. Blood clots on the right atrial disks in two patients (one required lysis) were seen during follow up transoesophageal echocardiography. Serious complications demanding surgical removal of the device occurred in three patients. One patient had haemopericardial tamponade because of an aortic lesion. Left atrial thrombus formation due to an unfolded right atrial disk was found in a second patient and dislodgement of the left atrial disk resulted in a large residual shunt in a third.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Percutaneous closure of a central ASD with a diameter \u2a7d\u200920\u2009mm in paediatric and adult patients is feasible and effective with this new device. It is a promising alternative to surgical closure. Modifications of the design, however, seem to be mandatory as 4% of patients developed serious complications.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/hrt.80.5.517","type":"journal-article","created":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T15:31:45Z","timestamp":1413991905000},"page":"517-521","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":73,"title":["Percutaneous closure of secundum atrial septal defect with a new self centring device (\u201cangel wings\u201d)"],"prefix":"10.1136","volume":"80","author":[{"given":"C","family":"Rickers","sequence":"first","affiliation":[{"name":"aDepartment of Paediatric Cardiology, University Hospital Eppendorf, Hamburg, Germany, \n\nbDepartment of Cardiology, University Hospital Eppendorf, \n\ncDepartment of Cardiology, Hospital Bethanien, Frankfurt, Germany, \n\ndDepartment of Paediatric Cardiology, University Hospital Gie\u03b2en, Germany, \n\neDepartment of Paediatric Cardiology, University Hospital, M\u00fcnster, Germany, \n\nfDepartment of Paediatric Cardiology, Heart Center Munich, Germany, \n\ngDepartment of Cardiology, Heart Center Bad Oeynhausen, Germany,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Hamm","sequence":"additional","affiliation":[{"name":"aDepartment of Paediatric Cardiology, University Hospital Eppendorf, Hamburg, Germany, \n\nbDepartment of Cardiology, University Hospital Eppendorf, \n\ncDepartment of Cardiology, Hospital Bethanien, Frankfurt, Germany, \n\ndDepartment of Paediatric Cardiology, University Hospital Gie\u03b2en, Germany, \n\neDepartment of Paediatric Cardiology, University Hospital, M\u00fcnster, Germany, \n\nfDepartment of Paediatric Cardiology, Heart Center Munich, Germany, \n\ngDepartment of Cardiology, Heart Center Bad Oeynhausen, Germany,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Stern","sequence":"additional","affiliation":[{"name":"aDepartment of Paediatric Cardiology, University Hospital Eppendorf, Hamburg, Germany, \n\nbDepartment of Cardiology, University Hospital Eppendorf, \n\ncDepartment of Cardiology, Hospital Bethanien, Frankfurt, Germany, \n\ndDepartment of Paediatric Cardiology, University Hospital Gie\u03b2en, Germany, \n\neDepartment of Paediatric Cardiology, University Hospital, M\u00fcnster, Germany, \n\nfDepartment of Paediatric Cardiology, Heart Center Munich, Germany, \n\ngDepartment of Cardiology, Heart Center Bad Oeynhausen, Germany,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Hofmann","sequence":"additional","affiliation":[{"name":"aDepartment of Paediatric Cardiology, University Hospital Eppendorf, Hamburg, Germany, \n\nbDepartment of Cardiology, University Hospital Eppendorf, \n\ncDepartment of Cardiology, Hospital Bethanien, Frankfurt, Germany, \n\ndDepartment of Paediatric Cardiology, University Hospital Gie\u03b2en, Germany, \n\neDepartment of Paediatric Cardiology, University Hospital, M\u00fcnster, Germany, \n\nfDepartment of Paediatric Cardiology, Heart Center Munich, Germany, \n\ngDepartment of Cardiology, Heart Center Bad Oeynhausen, Germany,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Franzen","sequence":"additional","affiliation":[{"name":"aDepartment of Paediatric Cardiology, University Hospital Eppendorf, Hamburg, Germany, \n\nbDepartment of Cardiology, University Hospital Eppendorf, \n\ncDepartment of Cardiology, Hospital Bethanien, Frankfurt, Germany, \n\ndDepartment of Paediatric Cardiology, University Hospital Gie\u03b2en, Germany, \n\neDepartment of Paediatric Cardiology, University Hospital, M\u00fcnster, Germany, \n\nfDepartment of Paediatric Cardiology, Heart Center Munich, Germany, \n\ngDepartment of Cardiology, Heart Center Bad Oeynhausen, Germany,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Schr\u00e4der","sequence":"additional","affiliation":[{"name":"aDepartment of Paediatric Cardiology, University Hospital Eppendorf, Hamburg, Germany, \n\nbDepartment of Cardiology, University Hospital Eppendorf, \n\ncDepartment of Cardiology, Hospital Bethanien, Frankfurt, Germany, \n\ndDepartment of Paediatric Cardiology, University Hospital Gie\u03b2en, Germany, \n\neDepartment of Paediatric Cardiology, University Hospital, M\u00fcnster, Germany, \n\nfDepartment of Paediatric Cardiology, Heart Center Munich, Germany, \n\ngDepartment of Cardiology, Heart Center Bad Oeynhausen, Germany,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Sievert","sequence":"additional","affiliation":[{"name":"aDepartment of Paediatric Cardiology, University Hospital Eppendorf, Hamburg, Germany, \n\nbDepartment of Cardiology, University Hospital Eppendorf, \n\ncDepartment of Cardiology, Hospital Bethanien, Frankfurt, Germany, \n\ndDepartment of Paediatric Cardiology, University Hospital Gie\u03b2en, Germany, \n\neDepartment of Paediatric Cardiology, University Hospital, M\u00fcnster, Germany, \n\nfDepartment of Paediatric Cardiology, Heart Center Munich, Germany, \n\ngDepartment of Cardiology, Heart Center Bad Oeynhausen, Germany,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Schranz","sequence":"additional","affiliation":[{"name":"aDepartment of Paediatric Cardiology, University Hospital Eppendorf, Hamburg, Germany, \n\nbDepartment of Cardiology, University Hospital Eppendorf, \n\ncDepartment of Cardiology, Hospital Bethanien, Frankfurt, Germany, \n\ndDepartment of Paediatric Cardiology, University Hospital Gie\u03b2en, Germany, \n\neDepartment of Paediatric Cardiology, University Hospital, M\u00fcnster, Germany, \n\nfDepartment of Paediatric Cardiology, Heart Center Munich, Germany, \n\ngDepartment of Cardiology, Heart Center Bad Oeynhausen, Germany,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Michel-Behnke","sequence":"additional","affiliation":[{"name":"aDepartment of Paediatric Cardiology, University Hospital Eppendorf, Hamburg, Germany, \n\nbDepartment of Cardiology, University Hospital Eppendorf, \n\ncDepartment of Cardiology, Hospital Bethanien, Frankfurt, Germany, \n\ndDepartment of Paediatric Cardiology, University Hospital Gie\u03b2en, Germany, \n\neDepartment of Paediatric Cardiology, University Hospital, M\u00fcnster, Germany, \n\nfDepartment of Paediatric Cardiology, Heart Center Munich, Germany, \n\ngDepartment of Cardiology, Heart Center Bad Oeynhausen, Germany,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Vogt","sequence":"additional","affiliation":[{"name":"aDepartment of Paediatric Cardiology, University Hospital Eppendorf, Hamburg, Germany, \n\nbDepartment of Cardiology, University Hospital Eppendorf, \n\ncDepartment of Cardiology, Hospital Bethanien, Frankfurt, Germany, \n\ndDepartment of Paediatric Cardiology, University Hospital Gie\u03b2en, Germany, \n\neDepartment of Paediatric Cardiology, University Hospital, M\u00fcnster, Germany, \n\nfDepartment of Paediatric Cardiology, Heart Center Munich, Germany, \n\ngDepartment of Cardiology, Heart Center Bad Oeynhausen, Germany,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Kececioglu","sequence":"additional","affiliation":[{"name":"aDepartment of Paediatric Cardiology, University Hospital Eppendorf, Hamburg, Germany, \n\nbDepartment of Cardiology, University Hospital Eppendorf, \n\ncDepartment of Cardiology, Hospital Bethanien, Frankfurt, Germany, \n\ndDepartment of Paediatric Cardiology, University Hospital Gie\u03b2en, Germany, \n\neDepartment of Paediatric Cardiology, University Hospital, M\u00fcnster, Germany, \n\nfDepartment of Paediatric Cardiology, Heart Center Munich, Germany, \n\ngDepartment of Cardiology, Heart Center Bad Oeynhausen, Germany,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Sebening","sequence":"additional","affiliation":[{"name":"aDepartment of Paediatric Cardiology, University Hospital Eppendorf, Hamburg, Germany, \n\nbDepartment of Cardiology, University Hospital Eppendorf, \n\ncDepartment of Cardiology, Hospital Bethanien, Frankfurt, Germany, \n\ndDepartment of Paediatric Cardiology, University Hospital Gie\u03b2en, Germany, \n\neDepartment of Paediatric Cardiology, University Hospital, M\u00fcnster, Germany, \n\nfDepartment of Paediatric Cardiology, Heart Center Munich, Germany, \n\ngDepartment of Cardiology, Heart Center Bad Oeynhausen, Germany,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Eicken","sequence":"additional","affiliation":[{"name":"aDepartment of Paediatric Cardiology, University Hospital Eppendorf, Hamburg, Germany, \n\nbDepartment of Cardiology, University Hospital Eppendorf, \n\ncDepartment of Cardiology, Hospital Bethanien, Frankfurt, Germany, \n\ndDepartment of Paediatric Cardiology, University Hospital Gie\u03b2en, Germany, \n\neDepartment of Paediatric Cardiology, University Hospital, M\u00fcnster, Germany, \n\nfDepartment of Paediatric Cardiology, Heart Center Munich, Germany, \n\ngDepartment of Cardiology, Heart Center Bad Oeynhausen, Germany,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Meyer","sequence":"additional","affiliation":[{"name":"aDepartment of Paediatric Cardiology, University Hospital Eppendorf, Hamburg, Germany, \n\nbDepartment of Cardiology, University Hospital Eppendorf, \n\ncDepartment of Cardiology, Hospital Bethanien, Frankfurt, Germany, \n\ndDepartment of Paediatric Cardiology, University Hospital Gie\u03b2en, Germany, \n\neDepartment of Paediatric Cardiology, University Hospital, M\u00fcnster, Germany, \n\nfDepartment of Paediatric Cardiology, Heart Center Munich, Germany, \n\ngDepartment of Cardiology, Heart Center Bad Oeynhausen, Germany,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Matthies","sequence":"additional","affiliation":[{"name":"aDepartment of Paediatric Cardiology, University Hospital Eppendorf, Hamburg, Germany, \n\nbDepartment of Cardiology, University Hospital Eppendorf, \n\ncDepartment of Cardiology, Hospital Bethanien, Frankfurt, Germany, \n\ndDepartment of Paediatric Cardiology, University Hospital Gie\u03b2en, Germany, \n\neDepartment of Paediatric Cardiology, University Hospital, M\u00fcnster, Germany, \n\nfDepartment of Paediatric Cardiology, Heart Center Munich, Germany, \n\ngDepartment of Cardiology, Heart Center Bad Oeynhausen, Germany,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Kleber","sequence":"additional","affiliation":[{"name":"aDepartment of Paediatric Cardiology, University Hospital Eppendorf, Hamburg, Germany, \n\nbDepartment of Cardiology, University Hospital Eppendorf, \n\ncDepartment of Cardiology, Hospital Bethanien, Frankfurt, Germany, \n\ndDepartment of Paediatric Cardiology, University Hospital Gie\u03b2en, Germany, \n\neDepartment of Paediatric Cardiology, University Hospital, M\u00fcnster, Germany, \n\nfDepartment of Paediatric Cardiology, Heart Center Munich, Germany, \n\ngDepartment of Cardiology, Heart Center Bad Oeynhausen, Germany,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Hug","sequence":"additional","affiliation":[{"name":"aDepartment of Paediatric Cardiology, University Hospital Eppendorf, Hamburg, Germany, \n\nbDepartment of Cardiology, University Hospital Eppendorf, \n\ncDepartment of Cardiology, Hospital Bethanien, Frankfurt, Germany, \n\ndDepartment of Paediatric Cardiology, University Hospital Gie\u03b2en, Germany, \n\neDepartment of Paediatric Cardiology, University Hospital, M\u00fcnster, Germany, \n\nfDepartment of Paediatric Cardiology, Heart Center Munich, Germany, \n\ngDepartment of Cardiology, Heart Center Bad Oeynhausen, Germany,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Weil","sequence":"additional","affiliation":[{"name":"aDepartment of Paediatric Cardiology, University Hospital Eppendorf, Hamburg, Germany, \n\nbDepartment of Cardiology, University Hospital Eppendorf, \n\ncDepartment of Cardiology, Hospital Bethanien, Frankfurt, Germany, \n\ndDepartment of Paediatric Cardiology, University Hospital Gie\u03b2en, Germany, \n\neDepartment of Paediatric Cardiology, University Hospital, M\u00fcnster, Germany, \n\nfDepartment of Paediatric Cardiology, Heart Center Munich, Germany, \n\ngDepartment of Cardiology, Heart Center Bad Oeynhausen, Germany,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1998,11,1]]},"reference":[{"key":"2025092000334011000_80.5.517.1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1976.03260490024013"},{"key":"2025092000334011000_80.5.517.2","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1161\/01.CIR.67.4.711","article-title":"Transcatheter treatment of congenital heart disease.","volume":"67","author":"Rashkind","year":"1983","journal-title":"Circulation"},{"key":"2025092000334011000_80.5.517.3","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5273(85)90165-2"},{"key":"2025092000334011000_80.5.517.4","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.79.5.1091"},{"key":"2025092000334011000_80.5.517.5","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1161\/01.CIR.82.3.751","article-title":"Double umbrella closure of atrial septal defects: initial clinical applications.","volume":"82","author":"Rome","year":"1990","journal-title":"Circulation"},{"key":"2025092000334011000_80.5.517.6","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(90)90552-C"},{"key":"2025092000334011000_80.5.517.7","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1161\/01.CIR.81.1.312","article-title":"Transvenous atrial septal defect occlusion in piglets with a \u201cbuttoned\u201d double disk device.","volume":"81","author":"Sideris","year":"1990","journal-title":"Circulation"},{"key":"2025092000334011000_80.5.517.8","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(90)90590-W"},{"key":"2025092000334011000_80.5.517.9","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.86.6.1902"},{"key":"2025092000334011000_80.5.517.10","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.75.3.593"},{"key":"2025092000334011000_80.5.517.11","first-page":"2518","article-title":"Atrial septal defect occlusion with the buttoned device: early FDA trial results [abstract].","volume":"86","author":"Lloyd","year":"1992","journal-title":"Circulation"},{"key":"2025092000334011000_80.5.517.12","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1161\/01.CIR.88.4.1754","article-title":"Experimental atrial septal defect closure with a new, transcatheter, self-centering device.","volume":"88","author":"Das","year":"1993","journal-title":"Circulation"},{"key":"2025092000334011000_80.5.517.13","first-page":"I","article-title":"Intermediate term follow up of patients after percutaeous closure of atrial septal defects with the Das angel wings device [abstract].","volume":"94","author":"Das","year":"1996","journal-title":"Circulation"},{"key":"2025092000334011000_80.5.517.14","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(92)90937-Q"},{"key":"2025092000334011000_80.5.517.15","unstructured":"King TD, Thompson SL, Mills NL. Measurement of atrial septal defect during cardiac catheterisation: experimental and clinical trials. Am J Cardiol."},{"key":"2025092000334011000_80.5.517.16","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.8.2162"},{"key":"2025092000334011000_80.5.517.17","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1161\/01.CIR.88.2.621","article-title":"Echocardiographic follow-up of atrial septal defect after catheter closure by double-umbrella device.","volume":"88","author":"Boutin","year":"1993","journal-title":"Circulation"},{"key":"2025092000334011000_80.5.517.18","first-page":"136","article-title":"Initial clinical experience of transcatheter closure of secundum atrial septal with a septal occlusion system. A multicenter European study [abstract].","volume":"18","author":"Carminati","year":"1997","journal-title":"Eur Heart J"},{"key":"2025092000334011000_80.5.517.19","first-page":"143","article-title":"Follow-up results of the multi-institutional phase I FDA supervised clinical trials of transcatheter occlusion of atrial septal defects with buttoned device [abstract].","volume":"29","author":"Zamora","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"2025092000334011000_80.5.517.20","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.75.1.83"},{"key":"2025092000334011000_80.5.517.21","first-page":"143","article-title":"ASD and PFO closure in adults with the second generation ASDOS device [abstract].","volume":"29","author":"Sievert","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"2025092000334011000_80.5.517.22","first-page":"I","article-title":"Secundum\u2014ASD closure with a new self-expanding prosthesis in swine [abstract].","volume":"94","author":"Sharafudin","year":"1996","journal-title":"Circulation"},{"key":"2025092000334011000_80.5.517.23","first-page":"135","article-title":"Transcatheter closure of atrial septal defect with a new nitinol double disk device (Amplatzer septal occluder). United Kingdom experience.","volume":"18","author":"Chan","year":"1997","journal-title":"Eur Hearts J"},{"key":"2025092000334011000_80.5.517.24","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90372-T"},{"key":"2025092000334011000_80.5.517.25","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(94)90498-7"},{"key":"2025092000334011000_80.5.517.26","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)90192-F"},{"key":"2025092000334011000_80.5.517.27","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199508243330801"},{"key":"2025092000334011000_80.5.517.28","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.71.3.219"},{"key":"2025092000334011000_80.5.517.29","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1093\/oxfordjournals.eurheartj.a060398","article-title":"Peri-operative complications following surgical closure of atrial septal defect type II in 232 patients\u2014a baseline study.","volume":"15","author":"Galal","year":"1994","journal-title":"Eur Heart J"},{"key":"2025092000334011000_80.5.517.30","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(73)90804-7"},{"key":"2025092000334011000_80.5.517.31","first-page":"155","article-title":"Secundum type atrial septal defects: early and late results of surgical repair using extracorporal circulation in 275 patients.","volume":"59","author":"Sellers","year":"1966","journal-title":"Surgery"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/hrt.80.5.517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T07:33:49Z","timestamp":1758353629000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/hrt.80.5.517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,11,1]]},"references-count":31,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1998,11,1]]},"published-print":{"date-parts":[[1998,11,1]]}},"alternative-id":["10.1136\/hrt.80.5.517"],"URL":"https:\/\/doi.org\/10.1136\/hrt.80.5.517","relation":{},"ISSN":["1355-6037","1468-201X"],"issn-type":[{"value":"1355-6037","type":"print"},{"value":"1468-201X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,11,1]]}}}