{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T04:55:08Z","timestamp":1774328108109,"version":"3.50.1"},"reference-count":20,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Heart"],"accepted":{"date-parts":[[1998,6,8]]},"published-print":{"date-parts":[[1999,2,1]]},"abstract":"<jats:p>Takayasu aortitis is a chronic inflammatory vasculitis characterised by stenosis or obliteration of large and medium sized arteries. Although coronary arteries are affected in approximately 10% of cases, most of the lesions are luminal narrowing, and coronary aneurysm formation is extremely rare. A case is described of giant aneurysm of the left main coronary artery complicated with Takayasu aortitis in a 46 year old Japanese woman who was followed until her death at age 71. Pronounced intimal proliferation and adventitial fibrous thickening of the involved arterial wall usually induce constriction or occlusion at the orifice of the main branch of the aorta in Takayasu aortitis. However, systemic hypertension, which resulted from renovascular stenoses in this case, is likely to have enlarged the vessel lumen before replacement of medial and adventitial fibrosis after extensive destruction of medial elastic fibres in the left main coronary artery. Moreover, associations such as autoimmune hepatitis, chronic thyroiditis, and Sj\u00f6gren syndrome strongly suggests that Takayasu aortitis may be an autoimmune disease.<\/jats:p>","DOI":"10.1136\/hrt.81.2.214","type":"journal-article","created":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T15:31:45Z","timestamp":1413991905000},"page":"214-217","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":36,"title":["Giant aneurysm of the left main coronary artery in Takayasu aortitis"],"prefix":"10.1136","volume":"81","author":[{"given":"H","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Cardiology, Juntendo University School of Medicine, 2\u20131\u20131 Hongo, Bunkyo-ku, Tokyo, 113\u20138421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Daida","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Juntendo University School of Medicine, 2\u20131\u20131 Hongo, Bunkyo-ku, Tokyo, 113\u20138421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Juntendo University School of Medicine, 2\u20131\u20131 Hongo, Bunkyo-ku, Tokyo, 113\u20138421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Juntendo University School of Medicine, 2\u20131\u20131 Hongo, Bunkyo-ku, Tokyo, 113\u20138421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Kawai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Juntendo University School of Medicine, 2\u20131\u20131 Hongo, Bunkyo-ku, Tokyo, 113\u20138421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Juntendo University School of Medicine, 2\u20131\u20131 Hongo, Bunkyo-ku, Tokyo, 113\u20138421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Juntendo University School of Medicine, 2\u20131\u20131 Hongo, Bunkyo-ku, Tokyo, 113\u20138421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1999,2,1]]},"reference":[{"key":"2025101721173905000_81.2.214.1","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1536\/ihj.4.224","article-title":"Aortic arch syndrome with special reference to pulseless disease and its variants.","volume":"4","author":"Ueda","year":"1963","journal-title":"Jpn Heart J"},{"key":"2025101721173905000_81.2.214.2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1177\/000331976301400502","article-title":"Pathology of pulseless disease: a systemic study and critical review of twenty-one autopsy cases reported in Japan.","volume":"14","author":"Nasu","year":"1963","journal-title":"Angiology"},{"key":"2025101721173905000_81.2.214.3","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.35.6.1141"},{"key":"2025101721173905000_81.2.214.4","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1536\/ihj.9.76","article-title":"Clinical and pathological studies of aortitis syndrome.","volume":"9","year":"1968","journal-title":"Jpn Heart J"},{"key":"2025101721173905000_81.2.214.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(77)80178-6"},{"key":"2025101721173905000_81.2.214.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(77)80139-2"},{"key":"2025101721173905000_81.2.214.7","first-page":"1007","article-title":"Coronary arterial involvement in Takayasu\u2019s disease.","volume":"23","author":"Naoki","year":"1981","journal-title":"Jpn Heart J"},{"key":"2025101721173905000_81.2.214.8","unstructured":"Nasu T. 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Acta Pathol Jpn1982;32(suppl 1):117\u201331."},{"key":"2025101721173905000_81.2.214.9","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1600-0447.1951.tb09677.x","article-title":"Syndrome of obliteration of the arterial branches of the aortic arch due to aortitis.","volume":"26","author":"Frovig","year":"1951","journal-title":"Acta Psychiatr Neurol Scand"},{"key":"2025101721173905000_81.2.214.10","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1536\/ihj.8.4","article-title":"Immunological studies of aortitis syndrome.","volume":"8","author":"Ueda","year":"1967","journal-title":"Jpn Heart J"},{"key":"2025101721173905000_81.2.214.11","first-page":"554","article-title":"A case with peculiar changes of the central retinal vessels in the retina.","volume":"12","author":"Takayasu","year":"1908","journal-title":"Acta Soc Ophthalmol Jap"},{"key":"2025101721173905000_81.2.214.12","first-page":"427","article-title":"Rheumatoid arthritis after Takayasu\u2019s arteritis.","volume":"13","author":"Rush","year":"1986","journal-title":"J Rheumatology"},{"key":"2025101721173905000_81.2.214.13","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.0954-6820.1966.tb05435.x","article-title":"Takayasu\u2019s arteritis and ankylosing spondylitis.","volume":"179","author":"Paloheimo","year":"1966","journal-title":"Acta Med Scand"},{"key":"2025101721173905000_81.2.214.14","first-page":"1215","article-title":"Takayasu\u2019s arteritis and ulcerative colitis.","volume":"81","author":"Achar","year":"1986","journal-title":"Am J Gastroenterol"},{"key":"2025101721173905000_81.2.214.15","first-page":"231","article-title":"Takayasu\u2019s arteritis. A study of 16 autopsy cases.","volume":"104","author":"Rose","year":"1980","journal-title":"Arch Pathol Lab Med"},{"key":"2025101721173905000_81.2.214.16","doi-asserted-by":"publisher","DOI":"10.1007\/BF01744540"},{"key":"2025101721173905000_81.2.214.17","first-page":"629","article-title":"An autopsy case of aortitis syndrome with aneurysms of bilateral coronary arteries [in Japanese].","volume":"11","author":"Fukuhara","year":"1979","journal-title":"Shinzo (Heart)"},{"key":"2025101721173905000_81.2.214.18","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1536\/ihj.24.1007","article-title":"Coronary artery aneurysm associated with aortitis syndrome diagnosed pre- and intraoperatively.","volume":"24","author":"Fukuda","year":"1983","journal-title":"Jpn Heart J"},{"key":"2025101721173905000_81.2.214.19","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(94)90409-X"},{"key":"2025101721173905000_81.2.214.20","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.4.1855"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/hrt.81.2.214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T04:17:48Z","timestamp":1760761068000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/hrt.81.2.214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,2,1]]},"references-count":20,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1999,2,1]]},"published-print":{"date-parts":[[1999,2,1]]}},"alternative-id":["10.1136\/hrt.81.2.214"],"URL":"https:\/\/doi.org\/10.1136\/hrt.81.2.214","relation":{},"ISSN":["1355-6037","1468-201X"],"issn-type":[{"value":"1355-6037","type":"print"},{"value":"1468-201X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,2,1]]}}}