{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T13:44:42Z","timestamp":1758462282517,"version":"3.44.0"},"reference-count":23,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Heart"],"accepted":{"date-parts":[[1998,9,21]]},"published-print":{"date-parts":[[1999,4,1]]},"abstract":"<jats:p>The percutaneous treatment of saphenous vein graft lesions containing angiographically massive thrombus is associated with a high risk of distal embolisation and no-reflow. The optimal management for these lesions remains unclear and a challenge to the interventional cardiologist. Five cases are described in whom the risks of percutaneous angioplasty were felt to be excessive owing to a high thrombus load. Each case was treated with a bolus and infusion of abciximab (ReoPro; Eli Lilly\u2014a platelet glycoprotein IIb\/IIIa receptor antagonist) at least 24 hours before further angiography. Repeat angiography of the culprit vein graft, following treatment with abciximab alone, demonstrated a major reduction in the thrombus score and the presence of TIMI 3 flow in each case. Immediately following repeat angiography, angioplasty with stent insertion was performed successfully with no distal embolisation or no-reflow phenomenon. This staged approach, with abciximab used alone to reduce thrombus load, is a new treatment for vein graft lesions containing massive thrombus.<\/jats:p>","DOI":"10.1136\/hrt.81.4.434","type":"journal-article","created":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T15:31:45Z","timestamp":1413991905000},"page":"434-437","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Platelet IIb\/IIIa antagonists followed by delayed stent implantation. A new treatment for vein graft lesions containing massive thrombus"],"prefix":"10.1136","volume":"81","author":[{"given":"N","family":"Robinson","sequence":"first","affiliation":[{"name":"aDepartment of Cardiology, London Chest Hospital, Bonner Road, London E2 9JX, UK, \n\nbDepartment of Cardiology, St Bartholomew\u2019s Hospital, West Smithfield, London EC1A 7BE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Barakat","sequence":"additional","affiliation":[{"name":"aDepartment of Cardiology, London Chest Hospital, Bonner Road, London E2 9JX, UK, \n\nbDepartment of Cardiology, St Bartholomew\u2019s Hospital, West Smithfield, London EC1A 7BE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Dymond","sequence":"additional","affiliation":[{"name":"aDepartment of Cardiology, London Chest Hospital, Bonner Road, London E2 9JX, UK, \n\nbDepartment of Cardiology, St Bartholomew\u2019s Hospital, West Smithfield, London EC1A 7BE, 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