{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:30:21Z","timestamp":1791923421106,"version":"4.3.4"},"reference-count":37,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Heart"],"accepted":{"date-parts":[[1999,2,16]]},"published-print":{"date-parts":[[1999,7,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>To analyse the spectrum of congenital heart malformations, the frequency of extracardiac malformations, and the proportion of chromosome aberrations among fetuses sent for necropsy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>MATERIAL<\/jats:title>\n                  <jats:p>Necropsies were performed on 815 fetuses\u2014448 induced abortions (55%), 220 spontaneous abortions (27%), and 147 stillbirths (18%)\u2014during a seven year period (1991\u201397) in the department of pathology of the Charit\u00e9 Medical Centre in Berlin. A congenital heart defect was identified in 129 cases (16%). For all 129 fetuses, karyotyping and an ultrasound examination had been performed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>Congenital heart defects were present in 22% of induced abortions (99 cases), 9% of spontaneous abortions (20 cases), and 7% of stillbirths (10 cases). The heart malformations were classified into 13 categories. A fetus with more than one defect was included only in the category of the most serious defect. The malformations in order of frequency were: ventricular septal defect (VSD) (28%), atrioventricular septal defect (AVSD) (16%), hypoplastic left heart (HLH) (16%), double outlet right ventricle (DORV) (12%), coarctation of the aorta (CoA) (6%), transposition of the great arteries (TGA) (4%), aortic valve stenosis (AoVS) (4%), tetralogy of Fallot (TOF) (3%), truncus arteriosus communis (TAC) (3%), pulmonary valve stenosis\/pulmonary valve atresia (PaVS\/PaVA) (3%), tricuspid atresia (TA) (3%), single ventricle (SV) (1.5%), and atrial septal defect (ASD) (0.5%). The most common congenital heart defects were VSD, AVSD, HLH, and DORV, which made up 72% of all the cases. In 11 cases the heart defect was isolated (no other cardiovascular or extracardiac malformations present), 85 cases (66%) were associated with additional cardiac malformations, 85 cases (66%) were associated with extracardiac malformations, and chromosome anomalies were detected in 43 cases (33%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Fetal congenital heart malformations are common. These defects are often associated with other cardiovascular and extracardiac malformations, as well as with chromosome anomalies. Complex heart defects such as AVSD, HLH, and DORV are frequent in fetuses, as they often lead to spontaneous abortion or stillbirth or, after prenatal diagnosis, to deliberate termination of pregnancy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/hrt.82.1.34","type":"journal-article","created":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T15:31:45Z","timestamp":1413991905000},"page":"34-39","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":169,"title":["Spectrum of congenital heart defects and extracardiac malformations associated with chromosomal abnormalities: results of a seven year necropsy study"],"prefix":"10.1136","volume":"82","author":[{"given":"C","family":"Tennstedt","sequence":"first","affiliation":[{"name":"aDepartment of Pathology, Charit\u00e9 Hospital of the Humboldt University, Berlin, Germany, \n\nbUnit of Prenatal Diagnosis and Therapy, Department of Gynaecology and Obstetrics, Charit\u00e9 Hospital, \n\ncInstitute of Medical Genetics, Charit\u00e9 Hospital, \n\ndDepartment of Pathology, Charit\u00e9 Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Chaoui","sequence":"additional","affiliation":[{"name":"aDepartment of Pathology, Charit\u00e9 Hospital of the Humboldt University, Berlin, Germany, \n\nbUnit of Prenatal Diagnosis and Therapy, Department of Gynaecology and Obstetrics, Charit\u00e9 Hospital, \n\ncInstitute of Medical Genetics, Charit\u00e9 Hospital, \n\ndDepartment of Pathology, Charit\u00e9 Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"K\u00f6rner","sequence":"additional","affiliation":[{"name":"aDepartment of Pathology, Charit\u00e9 Hospital of the Humboldt University, Berlin, Germany, \n\nbUnit of Prenatal Diagnosis and Therapy, Department of Gynaecology and Obstetrics, Charit\u00e9 Hospital, \n\ncInstitute of Medical Genetics, Charit\u00e9 Hospital, \n\ndDepartment of Pathology, Charit\u00e9 Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Dietel","sequence":"additional","affiliation":[{"name":"aDepartment of Pathology, Charit\u00e9 Hospital of the Humboldt University, Berlin, Germany, \n\nbUnit of Prenatal Diagnosis and Therapy, Department of Gynaecology and Obstetrics, Charit\u00e9 Hospital, \n\ncInstitute of Medical Genetics, Charit\u00e9 Hospital, \n\ndDepartment of Pathology, Charit\u00e9 Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1999,7,1]]},"reference":[{"key":"2025092101032095000_82.1.34.1","unstructured":"Ferencz C Rubin JD Loffredo CA (1993) Epidemiology of congenital heart disease: the Baltimore-Washington Infant Study 1981\u20131989. 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