{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:45:11Z","timestamp":1760204711388,"version":"3.44.0"},"reference-count":10,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Heart"],"accepted":{"date-parts":[[1999,3,17]]},"published-print":{"date-parts":[[1999,9,1]]},"abstract":"<jats:p>Two patients with a novel variant of long QT syndrome are described. The clinical course was characterised by an in utero onset of ventricular tachycardia and atrioventricular block (at 26 and 30 weeks\u2019 gestational age, respectively), and an association with a ventricular septal defect. Studies of both patients\u2019 families identified relatives with prolonged QT interval, syncope, or sudden death. One patient died of intractable ventricular tachycardia at 4 days old. The other received \u03b2 blocker treatment and a pacemaker. She died suddenly at the age of 10 months. The unique association with ventricular septal defect and the malignant clinical course warrants further molecular diagnosis of this novel variant of long QT syndrome.<\/jats:p>","DOI":"10.1136\/hrt.82.3.386","type":"journal-article","created":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T15:31:45Z","timestamp":1413991905000},"page":"386-388","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["A variant of long QT syndrome manifested as fetal tachycardia and associated with ventricular septal defect"],"prefix":"10.1136","volume":"82","author":[{"given":"M-H","family":"Wu","sequence":"first","affiliation":[{"name":"aDepartment of Pediatrics, National Taiwan University Hospital, No 7, Chung-Shen South Road, Taipei, Taiwan 100, \n\nbDepartment of Gynecology and Obstetrics, National Taiwan University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F-C","family":"Hsieh","sequence":"additional","affiliation":[{"name":"aDepartment of Pediatrics, National Taiwan University Hospital, No 7, Chung-Shen South Road, Taipei, Taiwan 100, \n\nbDepartment of Gynecology and Obstetrics, National Taiwan University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J-K","family":"Wang","sequence":"additional","affiliation":[{"name":"aDepartment of Pediatrics, National Taiwan University Hospital, No 7, Chung-Shen South Road, Taipei, Taiwan 100, \n\nbDepartment of Gynecology and Obstetrics, National Taiwan University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M-L","family":"Kau","sequence":"additional","affiliation":[{"name":"aDepartment of Pediatrics, National Taiwan University Hospital, No 7, Chung-Shen South Road, Taipei, Taiwan 100, \n\nbDepartment of Gynecology and Obstetrics, National Taiwan University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1999,9,1]]},"reference":[{"key":"2025092001233581000_82.3.386.1","first-page":"300","article-title":"The long QT syndrome.","volume":"22","author":"Schwartz","year":"1997","journal-title":"Curr Probl Cardiology"},{"key":"2025092001233581000_82.3.386.2","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/BF02505096","article-title":"Perinatal manifestations of idiopathic long QT syndrome.","volume":"17","author":"Mache","year":"1996","journal-title":"Pediatr Cardiol"},{"key":"2025092001233581000_82.3.386.3","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(92)90940-W"},{"key":"2025092001233581000_82.3.386.4","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.87.6.1866"},{"key":"2025092001233581000_82.3.386.5","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1055\/s-2007-993915","article-title":"Long QT syndrome manifested as fetal ventricular tachycardia and intermittent AV block.","volume":"15","author":"Lin","year":"1998","journal-title":"Am J Perinatol"},{"key":"2025092001233581000_82.3.386.6","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.77.3.198"},{"key":"2025092001233581000_82.3.386.7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199806113382401"},{"key":"2025092001233581000_82.3.386.8","unstructured":"Rosenthal G (1998) Prevalence of congenital heart disease. in The science and practice of pediatric cardiology. eds Garson A Jr Bricker JT Fisher DJ (Williams & Wilkins, Baltimore), pp 1083\u20131105."},{"key":"2025092001233581000_82.3.386.9","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1111\/j.1540-8159.1997.tb03626.x","article-title":"Molecular biology of the long QT syndrome: impact on management.","volume":"20","author":"Priori","year":"1997","journal-title":"PACE"},{"key":"2025092001233581000_82.3.386.10","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.92.10.2929"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/hrt.82.3.386","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T08:23:44Z","timestamp":1758356624000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/hrt.82.3.386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,9,1]]},"references-count":10,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1999,9,1]]},"published-print":{"date-parts":[[1999,9,1]]}},"alternative-id":["10.1136\/hrt.82.3.386"],"URL":"https:\/\/doi.org\/10.1136\/hrt.82.3.386","relation":{},"ISSN":["1355-6037","1468-201X"],"issn-type":[{"type":"print","value":"1355-6037"},{"type":"electronic","value":"1468-201X"}],"subject":[],"published":{"date-parts":[[1999,9,1]]}}}