{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T21:05:23Z","timestamp":1771362323012,"version":"3.50.1"},"reference-count":11,"publisher":"BMJ","issue":"5","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Heart"],"accepted":{"date-parts":[[1999,2,2]]},"published-print":{"date-parts":[[1999,11,1]]},"abstract":"\n OBJECTIVE<\/jats:title>\n To assess the efficacy and complications of device occlusion of atrial septal defects in adults, using the Amplatzer septal occluder (ASO).<\/jats:p>\n <\/jats:sec>\n \n DESIGN<\/jats:title>\n A prospective interventional study.<\/jats:p>\n <\/jats:sec>\n \n SETTING<\/jats:title>\n Paediatric cardiology departments in two European teaching hospitals.<\/jats:p>\n <\/jats:sec>\n \n PATIENTS<\/jats:title>\n The first 20 patients accepted for atrial septal defect device occlusion, on the basis of transoesophageal echocardiography. Sixteen patients had larger defects with right heart dilatation, while the primary indication for closure in four was a history of early paradoxical embolism.<\/jats:p>\n <\/jats:sec>\n \n INTERVENTIONS<\/jats:title>\n Transcatheter atrial septal defect occlusions performed under transoesophageal echocardiography and fluoroscopic guidance between December 1996 and June 1998.<\/jats:p>\n <\/jats:sec>\n \n OUTCOME MEASURES<\/jats:title>\n Success of deployment of ASO devices, procedure and fluoroscopic times, complications, and symptoms.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n The ASO device was successfully implanted in all 20 patients (14 female), median age 44.2 years, with no complications. Of the 16 patients with right heart dilatation, the median Qp:Qs was 2.5:1. Defects measured 11\u201322 mm (median 18) on transoesophageal echocardiography, with balloon sized diameter (and device size) of 13\u201328 mm (median 20). For all 20 patients, the procedure time ranged from 38\u201378 minutes (median 61), and fluoroscopy 8.4\u201324.7 minutes (median 15.2). There were residual shunts in three patients at the end of the procedure, which were trivial (\u2a7d\u20091\u2009mm) as assessed by transoesophageal echocardiography, and persisted for more than six months in only one patient. Follow up ranged from 0.1\u20131.5 years (median 0.7). There have been no late complications.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS<\/jats:title>\n The ASO device can be used successfully to close selected oval fossa defects in adults, with minimal procedural morbidity and excellent early results.<\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/hrt.82.5.559","type":"journal-article","created":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T15:31:45Z","timestamp":1413991905000},"page":"559-562","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":47,"title":["Transcatheter closure of atrial septal defects in adults with the Amplatzer septal occluder"],"prefix":"10.1136","volume":"82","author":[{"given":"R","family":"Dhillon","sequence":"first","affiliation":[{"name":"aDepartment of Paediatric Cardiology, Royal Brompton and Harefield Hospital NHS Trust, London, UK, \n\nbDepartment of Paediatric Cardiology, Aghia Sophia Children's Hospital, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Thanopoulos","sequence":"additional","affiliation":[{"name":"aDepartment of Paediatric Cardiology, Royal Brompton and Harefield Hospital NHS Trust, London, UK, \n\nbDepartment of Paediatric Cardiology, Aghia Sophia Children's Hospital, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Tsaousis","sequence":"additional","affiliation":[{"name":"aDepartment of Paediatric Cardiology, Royal Brompton and Harefield Hospital NHS Trust, London, UK, \n\nbDepartment of Paediatric Cardiology, Aghia Sophia Children's Hospital, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Triposkiadis","sequence":"additional","affiliation":[{"name":"aDepartment of Paediatric Cardiology, Royal Brompton and Harefield Hospital NHS Trust, London, UK, \n\nbDepartment of Paediatric Cardiology, Aghia Sophia Children's Hospital, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Kyriakidis","sequence":"additional","affiliation":[{"name":"aDepartment of Paediatric Cardiology, Royal Brompton and Harefield Hospital NHS Trust, London, UK, \n\nbDepartment of Paediatric Cardiology, Aghia Sophia Children's Hospital, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Redington","sequence":"additional","affiliation":[{"name":"aDepartment of Paediatric Cardiology, Royal Brompton and Harefield Hospital NHS Trust, London, UK, \n\nbDepartment of Paediatric Cardiology, Aghia Sophia Children's Hospital, Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1999,11,1]]},"reference":[{"key":"2025100704545530000_82.5.559.1","first-page":"794","article-title":"Incidence of congenital heart disease in children born to residents of Olmsted County, Minnesota, 1950\u20131969.","volume":"46","author":"Feldt","year":"1971","journal-title":"Mayo Clin Proc"},{"key":"2025100704545530000_82.5.559.2","first-page":"31","article-title":"Closure of atrial septal defect in adult life.","volume":"41","author":"Oakley","year":"1996","journal-title":"Cardiologia"},{"key":"2025100704545530000_82.5.559.3","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.71.3.224"},{"key":"2025100704545530000_82.5.559.4","doi-asserted-by":"publisher","DOI":"10.1136\/adc.75.2.96"},{"key":"2025100704545530000_82.5.559.5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199508243330809"},{"key":"2025100704545530000_82.5.559.6","first-page":"330","article-title":"Adults with congenital heart defects: clinical spectrum and surgical management.","volume":"21","author":"Berdjis","year":"1996","journal-title":"Herz"},{"key":"2025100704545530000_82.5.559.7","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(95)01043-2"},{"key":"2025100704545530000_82.5.559.8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1976.03260490024013"},{"key":"2025100704545530000_82.5.559.9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199508243330801"},{"key":"2025100704545530000_82.5.559.10","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.72.4.372"},{"key":"2025100704545530000_82.5.559.11","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1136\/hrt.80.1.54","article-title":"Extending the limits of transcatheter closure of atrial septal defects with the double umbrella device (Cardioseal).","volume":"80","author":"Kaulitz","year":"1998","journal-title":"Heart"}],"container-title":["Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/hrt.82.5.559","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T11:55:05Z","timestamp":1759838105000},"score":1,"resource":{"primary":{"URL":"https:\/\/heart.bmj.com\/lookup\/doi\/10.1136\/hrt.82.5.559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,11,1]]},"references-count":11,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1999,11,1]]},"published-print":{"date-parts":[[1999,11,1]]}},"alternative-id":["10.1136\/hrt.82.5.559"],"URL":"https:\/\/doi.org\/10.1136\/hrt.82.5.559","relation":{},"ISSN":["1355-6037","1468-201X"],"issn-type":[{"value":"1355-6037","type":"print"},{"value":"1468-201X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,11,1]]}}}