{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T06:08:48Z","timestamp":1760249328667,"version":"3.44.0"},"reference-count":35,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Heart"],"accepted":{"date-parts":[[1999,6,7]]},"published-print":{"date-parts":[[1999,12,1]]},"abstract":"<jats:sec>\n                  <jats:title>OBJECTIVE<\/jats:title>\n                  <jats:p>To assess left ventricular function in adult Fallot patients with residual pulmonary regurgitation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>SETTING<\/jats:title>\n                  <jats:p>The radiology department of a tertiary referral centre.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>PATIENTS<\/jats:title>\n                  <jats:p>14 patients with chronic pulmonary regurgitation and right ventricular volume overload after repair of tetralogy of Fallot and 10 healthy subjects were studied using magnetic resonance imaging.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>MAIN OUTCOME MEASURES<\/jats:title>\n                  <jats:p>Biventricular volumes, global biventricular function, and regional left ventricular function were assessed in all subjects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>RESULTS<\/jats:title>\n                  <jats:p>The amount of pulmonary regurgitation in patients (mean (SD)) was 25 (18)% of forward flow and correlated significantly with right ventricular enlargement (p\u2009&lt;\u20090.05). Left ventricular end diastolic volume was decreased in patients (78 (11) <jats:italic>v<\/jats:italic> 88 (10) ml\/m<jats:sup>2<\/jats:sup>; p\u2009&lt;\u20090.05), ejection fraction was not significantly altered (59 (5)% <jats:italic>v<\/jats:italic> 55 (7)%; NS). No significant correlation was found between pulmonary regurgitation and left ventricular function. Overall left ventricular end diastolic wall thickness was significantly lower in patients (5.06 (0.72) <jats:italic>v<\/jats:italic> 6.06 (1.06) mm; p\u2009&lt;\u20090.05), predominantly in the free wall. At the apical level, left ventricular systolic wall thickening was 20% higher in Fallot patients (p\u2009&lt;\u20090.05). Left ventricular shape was normal.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>CONCLUSIONS<\/jats:title>\n                  <jats:p>Adult Fallot patients with mild chronic pulmonary regurgitation and subsequent right ventricular enlargement showed a normal left ventricular shape and global function. Although the left ventricular free wall had reduced wall thickness, compensatory hypercontractility of the apex may contribute to preserved global function.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/hrt.82.6.697","type":"journal-article","created":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T15:31:45Z","timestamp":1413991905000},"page":"697-703","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Left ventricular function in adults with mild pulmonary insufficiency late after Fallot repair"],"prefix":"10.1136","volume":"82","author":[{"given":"R A","family":"Niezen","sequence":"first","affiliation":[{"name":"aDepartment of Radiology, Leiden University Medical Centre, Albinusdreef 2, 2333 AA Leiden, Netherlands, \n\nbDepartment of Cardiology, Leiden University Medical Centre, \n\ncLaboratory for Clinical and Experimental Image Processing, Leiden University Medical Centre, \n\ndDivision of Paediatric Cardiology of the Department of Paediatrics, Leiden University Medical Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W A","family":"Helbing","sequence":"additional","affiliation":[{"name":"aDepartment of Radiology, Leiden University Medical Centre, Albinusdreef 2, 2333 AA Leiden, Netherlands, \n\nbDepartment of Cardiology, Leiden University Medical Centre, \n\ncLaboratory for Clinical and Experimental Image Processing, Leiden University Medical Centre, \n\ndDivision of Paediatric Cardiology of the Department of Paediatrics, Leiden University Medical Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E E","family":"van der Wall","sequence":"additional","affiliation":[{"name":"aDepartment of Radiology, Leiden University Medical Centre, Albinusdreef 2, 2333 AA Leiden, Netherlands, \n\nbDepartment of Cardiology, Leiden University Medical Centre, \n\ncLaboratory for Clinical and Experimental Image Processing, Leiden University Medical Centre, \n\ndDivision of Paediatric Cardiology of the Department of Paediatrics, Leiden University Medical Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R J","family":"van der Geest","sequence":"additional","affiliation":[{"name":"aDepartment of Radiology, Leiden University Medical Centre, Albinusdreef 2, 2333 AA Leiden, Netherlands, \n\nbDepartment of Cardiology, Leiden University Medical Centre, \n\ncLaboratory for Clinical and Experimental Image Processing, Leiden University Medical Centre, \n\ndDivision of Paediatric Cardiology of the Department of Paediatrics, Leiden University Medical Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H W","family":"Vliegen","sequence":"additional","affiliation":[{"name":"aDepartment of Radiology, Leiden University Medical Centre, Albinusdreef 2, 2333 AA Leiden, Netherlands, \n\nbDepartment of Cardiology, Leiden University Medical Centre, \n\ncLaboratory for Clinical and Experimental Image Processing, Leiden University Medical Centre, \n\ndDivision of Paediatric Cardiology of the Department of Paediatrics, Leiden University Medical Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"de Roos","sequence":"additional","affiliation":[{"name":"aDepartment of Radiology, Leiden University Medical Centre, Albinusdreef 2, 2333 AA Leiden, Netherlands, \n\nbDepartment of Cardiology, Leiden University Medical Centre, \n\ncLaboratory for Clinical and Experimental Image Processing, Leiden University Medical Centre, \n\ndDivision of Paediatric Cardiology of the Department of Paediatrics, Leiden University Medical Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1999,12,1]]},"reference":[{"key":"2025092012562703000_82.6.697.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199308263290901"},{"key":"2025092012562703000_82.6.697.2","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/S0022-5223(19)37504-X","article-title":"The influence of pulmonary insufficiency on ventricular function following repair of tetralogy of Fallot. 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