{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T15:56:00Z","timestamp":1787932560270,"version":"build-2784847793"},"reference-count":41,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Heart"],"accepted":{"date-parts":[[1999,7,30]]},"published-print":{"date-parts":[[1999,12,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To document the natural history and surgical outcomes for discrete subaortic stenosis in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DESIGN<\/jats:title>\n                    <jats:p>Retrospective review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SETTING<\/jats:title>\n                    <jats:p>Tertiary care paediatric cardiology centres.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PATIENTS<\/jats:title>\n                    <jats:p>92 children diagnosed between 1985 and 1998.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MAIN OUTCOME MEASURES<\/jats:title>\n                    <jats:p>Echocardiographic left ventricular outflow gradient (echograd), and aortic insufficiency  (AI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The mean (SEM) age at diagnosis was 5.3 (0.4) years; the mean echograd was 30 (2)\u2009mm\u2009Hg, with AI in 22% (19\/87) of patients. The echograd and incidence of AI increased to 35 (3)\u2009mm\u2009Hg and 53% (36\/68) (p\u2009&lt;\u20090.05) 3.6 (0.3) years later. The echograd at diagnosis predicted echograd progression and appearance of AI. 42 patients underwent surgery 2.2 (0.4) years after diagnosis. Preoperatively echograd and AI incidence increased to 58 (6)\u2009mm\u2009Hg and 76% (19\/25) (p\u2009&lt;\u20090.05). The echograd was 26 (4)\u2009mm\u2009Hg 3.7 (0.4) years postoperatively, with AI in 82% (31\/38) of patients. Surgical morbidities included complete heart block, need for prosthetic valves, and iatrogenic ventricular septal defects. Eight patients underwent reoperation for recurrent subaortic stenosis. The age at diagnosis of 44 patients followed medically and 42 patients operated on did not differ (5.5 (0.6)\n                      <jats:italic>v<\/jats:italic>\n                      5.0 (0.6) years, p\u2009&lt;\u20090.05). However, the echograd at diagnosis in the former was less (21 (2)\n                      <jats:italic>v<\/jats:italic>\n                      40 (5)\u2009mm\u2009Hg, p\u2009&lt;\u20090.05) and did not increase (23 (2)\u2009mm\u2009Hg) despite longer follow up (4.1 (0.4)\n                      <jats:italic>v<\/jats:italic>\n                      2.2 (0.4) years, p\u2009&lt;\u20090.05). The incidence of AI at diagnosis and at last medical follow up was also less (14%\u2009(6\/44)\n                      <jats:italic>v<\/jats:italic>\n                      34%\u2009(13\/38); 40% (17\/43)\n                      <jats:italic>v<\/jats:italic>\n                      76% (19\/25), p\u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>Many children with mild subaortic stenosis exhibit little progression of obstruction or AI and need not undergo immediate surgery. Others with more severe subaortic stenosis may progress precipitously and will benefit from early resection despite risks of surgical morbidity and recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/hrt.82.6.708","type":"journal-article","created":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T15:31:45Z","timestamp":1413991905000},"page":"708-713","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":67,"title":["Natural history and surgical outcomes for isolated discrete subaortic stenosis in children"],"prefix":"10.1136","volume":"82","author":[{"given":"C V","family":"Rohlicek","sequence":"first","affiliation":[{"name":"aDivision of Cardiology, Montr\u00e9al Children's Hospital, 2300 Tupper Street, Montr\u00e9al, Qu\u00e9bec H3H 1P3, Canada, \n\nbDivision of Cardiology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada, \n\ncDepartement de Cardiologie, H\u00f4pital Ste Justine, Montr\u00e9al, Qu\u00e9bec, Canada, \n\ndDepartement de Cardiologie, Centre Hospitalier de l'Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada, \n\neDivision of Cardiology, Izaak Walton Killam Hospital, Halifax, Nova Scotia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S Font","family":"del Pino","sequence":"additional","affiliation":[{"name":"aDivision of Cardiology, Montr\u00e9al Children's Hospital, 2300 Tupper Street, Montr\u00e9al, Qu\u00e9bec H3H 1P3, Canada, \n\nbDivision of Cardiology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada, \n\ncDepartement de Cardiologie, H\u00f4pital Ste Justine, Montr\u00e9al, Qu\u00e9bec, Canada, \n\ndDepartement de Cardiologie, Centre Hospitalier de l'Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada, \n\neDivision of Cardiology, Izaak Walton Killam Hospital, Halifax, Nova Scotia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Hosking","sequence":"additional","affiliation":[{"name":"aDivision of Cardiology, Montr\u00e9al Children's Hospital, 2300 Tupper Street, Montr\u00e9al, Qu\u00e9bec H3H 1P3, Canada, \n\nbDivision of Cardiology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada, \n\ncDepartement de Cardiologie, H\u00f4pital Ste Justine, Montr\u00e9al, Qu\u00e9bec, Canada, \n\ndDepartement de Cardiologie, Centre Hospitalier de l'Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada, \n\neDivision of Cardiology, Izaak Walton Killam Hospital, Halifax, Nova Scotia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Miro","sequence":"additional","affiliation":[{"name":"aDivision of Cardiology, Montr\u00e9al Children's Hospital, 2300 Tupper Street, Montr\u00e9al, Qu\u00e9bec H3H 1P3, Canada, \n\nbDivision of Cardiology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada, \n\ncDepartement de Cardiologie, H\u00f4pital Ste Justine, Montr\u00e9al, Qu\u00e9bec, Canada, \n\ndDepartement de Cardiologie, Centre Hospitalier de l'Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada, \n\neDivision of Cardiology, Izaak Walton Killam Hospital, Halifax, Nova Scotia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J-M","family":"C\u00f4t\u00e9","sequence":"additional","affiliation":[{"name":"aDivision of Cardiology, Montr\u00e9al Children's Hospital, 2300 Tupper Street, Montr\u00e9al, Qu\u00e9bec H3H 1P3, Canada, \n\nbDivision of Cardiology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada, \n\ncDepartement de Cardiologie, H\u00f4pital Ste Justine, Montr\u00e9al, Qu\u00e9bec, Canada, \n\ndDepartement de Cardiologie, Centre Hospitalier de l'Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada, \n\neDivision of Cardiology, Izaak Walton Killam Hospital, Halifax, Nova Scotia, 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