{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T04:46:17Z","timestamp":1778906777380,"version":"3.51.4"},"reference-count":33,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["international-journal-of-gynecological-cancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Gynecological Cancer"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1136\/ijgc-2023-004435","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T12:35:37Z","timestamp":1686832537000},"page":"1169-1178","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Prognostic factors in patients with endometrial cancer with isolated lymphatic recurrence"],"prefix":"10.1016","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5987-6654","authenticated-orcid":false,"given":"Ilaria","family":"Capasso","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5840-699X","authenticated-orcid":false,"given":"Simone","family":"Garzon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjeev","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy L.","family":"Weaver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela","family":"Mc Gree","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi Antonio","family":"De Vitis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Uccella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivy","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9413-316X","authenticated-orcid":false,"given":"Gretchen","family":"Glaser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9361-8392","authenticated-orcid":false,"given":"Carrie","family":"Langstraat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2758-1063","authenticated-orcid":false,"given":"Giovanni","family":"Scambia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1991-7284","authenticated-orcid":false,"given":"Francesco","family":"Fanfani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8059-1602","authenticated-orcid":false,"given":"Andrea","family":"Mariani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1136\/ijgc-2023-004435_bb0010","first-page":"7","article-title":"Cancer statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J Clin"},{"key":"10.1136\/ijgc-2023-004435_bb0015","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1097\/IGC.0000000000000891","article-title":"Paclitaxel, carboplatin, and bevacizumab in advanced and recurrent endometrial carcinoma","volume":"27","author":"Rose","year":"2017","journal-title":"Int J Gynecol Cancer"},{"key":"10.1136\/ijgc-2023-004435_bb0020","doi-asserted-by":"crossref","DOI":"10.3802\/jgo.2021.32.e45","article-title":"Laparoscopic vs. robotic-assisted laparoscopy in endometrial cancer staging: large retrospective single-institution study","volume":"32","author":"Perrone","year":"2021","journal-title":"J Gynecol Oncol"},{"key":"10.1136\/ijgc-2023-004435_bb0025","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0090-8258(84)90063-5","article-title":"Recurrent adenocarcinoma of the endometrium: a clinical and histopathological study of 379 patients","volume":"17","author":"Aalders","year":"1984","journal-title":"Gynecol Oncol"},{"key":"10.1136\/ijgc-2023-004435_bb0030","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ygyno.2008.06.010","article-title":"What is the incidence of isolated paraaortic nodal recurrence in grade 1 endometrial carcinoma","volume":"111","author":"Abu-Rustum","year":"2008","journal-title":"Gynecol Oncol"},{"key":"10.1136\/ijgc-2023-004435_bb0035","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ygyno.2004.06.042","article-title":"High-risk endometrial cancer subgroups: candidates for target-based adjuvant therapy","volume":"95","author":"Mariani","year":"2004","journal-title":"Gynecol Oncol"},{"key":"10.1136\/ijgc-2023-004435_bb0040","doi-asserted-by":"crossref","first-page":"e631","DOI":"10.1016\/j.ijrobp.2011.04.013","article-title":"Fifteen-year radiotherapy outcomes of the randomized PORTEC-1 trial for endometrial carcinoma","volume":"81","author":"Creutzberg","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1136\/ijgc-2023-004435_bb0045","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1097\/COC.0b013e31829a2974","article-title":"Advances in the management of recurrent endometrial cancer","volume":"38","author":"Bradford","year":"2015","journal-title":"Am J Clin Oncol"},{"key":"10.1136\/ijgc-2023-004435_bb0050","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1136\/ijgc-2020-002230","article-title":"ESGO\/ESTRO\/ESP guidelines for the management of patients with endometrial carcinoma","volume":"31","author":"Concin","year":"2021","journal-title":"Int J Gynecol Cancer"},{"key":"10.1136\/ijgc-2023-004435_bb0055","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/j.jtho.2017.05.015","article-title":"Long-term outcome of surgery or stereotactic radiotherapy for lung oligometastases","volume":"12","author":"Lodeweges","year":"2017","journal-title":"J Thorac Oncol"},{"key":"10.1136\/ijgc-2023-004435_bb0060","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1016\/S0140-6736(18)32487-5","article-title":"Stereotactic ablative radiotherapy versus standard of care palliative treatment in patients with oligometastatic cancers (SABR-COMET): a randomised, phase 2, open-label trial","volume":"393","author":"Palma","year":"2019","journal-title":"Lancet"},{"key":"10.1136\/ijgc-2023-004435_bb0065","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1097\/IGC.0000000000000543","article-title":"Salvage cytoreductive surgery for recurrent endometrial cancer","volume":"25","author":"Turan","year":"2015","journal-title":"Int J Gynecol Cancer"},{"key":"10.1136\/ijgc-2023-004435_bb0070","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/S0140-6736(09)62163-2","article-title":"Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial","volume":"375","author":"Nout","year":"2010","journal-title":"Lancet"},{"key":"10.1136\/ijgc-2023-004435_bb0075","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/s41416-018-0310-8","article-title":"Ten-year results of the PORTEC-2 trial for high-intermediate risk endometrial carcinoma: improving patient selection for adjuvant therapy","volume":"119","author":"Wortman","year":"2018","journal-title":"Br J Cancer"},{"key":"10.1136\/ijgc-2023-004435_bb0080","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ygyno.2015.07.096","article-title":"Management of nodal recurrences of endometrial cancer with IMRT","volume":"139","author":"Ho","year":"2015","journal-title":"Gynecol Oncol"},{"key":"10.1136\/ijgc-2023-004435_bb0085","doi-asserted-by":"crossref","first-page":"38","DOI":"10.4274\/jtgga.galenos.2021.2021.0072","article-title":"Evaluation of peripheral nodal recurrence in patients with endometrial cancer","volume":"23","author":"K\u0131l\u0131\u00e7","year":"2022","journal-title":"J Turk Ger Gynecol Assoc"},{"key":"10.1136\/ijgc-2023-004435_bb0090","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1002\/1097-0142(19880615)61:12<2561::AID-CNCR2820611229>3.0.CO;2-2","article-title":"Isolated peripheral lymph node recurrence of endometrial carcinoma","volume":"61","author":"Foote","year":"1988","journal-title":"Cancer"},{"key":"10.1136\/ijgc-2023-004435_bb0095","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1007\/s10147-019-01469-z","article-title":"Predictors of favorable survival after secondary cytoreductive surgery for recurrent endometrial cancer","volume":"24","author":"Shikama","year":"2019","journal-title":"Int J Clin Oncol"},{"key":"10.1136\/ijgc-2023-004435_bb0100","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/GRF.0b013e318218c6d1","article-title":"Recurrent endometrial cancer","volume":"54","author":"Del Carmen","year":"2011","journal-title":"Clin Obstet Gynecol"},{"key":"10.1136\/ijgc-2023-004435_bb0105","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14174176","article-title":"Recurrent endometrial cancer: which is the best treatment? Systematic review of the literature","volume":"14","author":"Restaino","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1136\/ijgc-2023-004435_bb0110","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1016\/j.ejca.2015.05.015","article-title":"Substantial lymph-vascular space invasion (LVSI) is a significant risk factor for recurrence in endometrial cancer--a pooled analysis of PORTEC 1 and 2 trials","volume":"51","author":"Bosse","year":"2015","journal-title":"Eur J Cancer"},{"key":"10.1136\/ijgc-2023-004435_bb0115","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ejca.2020.10.011","article-title":"Semiquantitative evaluation of lymph-vascular space invasion in patients affected by endometrial cancer: prognostic and clinical implications","volume":"142","author":"Restaino","year":"2021","journal-title":"Eur J Cancer"},{"key":"10.1136\/ijgc-2023-004435_bb0120","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1006\/gyno.2001.6550","article-title":"Predictors of lymphatic failure in endometrial cancer","volume":"84","author":"Mariani","year":"2002","journal-title":"Gynecol Oncol"},{"key":"10.1136\/ijgc-2023-004435_bb0125","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0360-3016(92)90675-8","article-title":"Endometrial cancer with para-aortic adenopathy: patterns of failure and opportunities for cure","volume":"24","author":"Corn","year":"1992","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1136\/ijgc-2023-004435_bb0130","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1006\/gyno.1999.5688","article-title":"Potential therapeutic role of para-aortic lymphadenectomy in node-positive endometrial cancer","volume":"76","author":"Mariani","year":"2000","journal-title":"Gynecol Oncol"},{"key":"10.1136\/ijgc-2023-004435_bb0135","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1006\/gyno.2000.6050","article-title":"Significance of pathologic patterns of pelvic lymph node metastases in endometrial cancer","volume":"80","author":"Mariani","year":"2001","journal-title":"Gynecol Oncol"},{"key":"10.1136\/ijgc-2023-004435_bb0140","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ygyno.2019.08.005","article-title":"Comparing risk stratification criteria for predicting lymphatic dissemination in endometrial cancer","volume":"155","author":"Kilts","year":"2019","journal-title":"Gynecol Oncol"},{"key":"10.1136\/ijgc-2023-004435_bb0145","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1097\/IGC.0000000000001296","article-title":"A proposal for a classification for recurrent endometrial cancer: analysis of a French multicenter database from the FRANCOGYN study group","volume":"28","author":"Bricou","year":"2018","journal-title":"Int J Gynecol Cancer"},{"key":"10.1136\/ijgc-2023-004435_bb0150","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000006920","article-title":"Stratification of risk groups according to survival after recurrence in endometrial cancer patients","volume":"96","author":"Shim","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"10.1136\/ijgc-2023-004435_bb0155","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.crad.2006.06.015","article-title":"Recurrent endometrial cancer: patterns of recurrent disease and assessment of prognosis","volume":"62","author":"Sohaib","year":"2007","journal-title":"Clin Radiol"},{"key":"10.1136\/ijgc-2023-004435_bb0160","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ygyno.2016.10.025","article-title":"Patterns of recurrence and outcomes in surgically treated women with endometrial cancer according to ESMO-ESGO-ESTRO consensus conference risk groups: results from the FRANCOGYN study group","volume":"144","author":"Bendifallah","year":"2017","journal-title":"Gynecol Oncol"},{"key":"10.1136\/ijgc-2023-004435_bb0165","first-page":"535","article-title":"Cytoreductive surgery for isolated para-aortic lymph node recurrence of endometrial cancer: report of four cases and a review of the literature","volume":"35","author":"Nakamura","year":"2014","journal-title":"Eur J Gynaecol Oncol"},{"key":"10.1136\/ijgc-2023-004435_bb0170","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.ygyno.2018.09.021","article-title":"Patterns of FIRST recurrence of stage Iiic1 endometrial cancer with no PARAAORTIC nodal assessment","volume":"151","author":"Aloisi","year":"2018","journal-title":"Gynecol Oncol"}],"container-title":["International Journal of Gynecological Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1048891X24016669?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1048891X24016669?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/ijgc-2023-004435","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T01:29:00Z","timestamp":1753234140000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1048891X24016669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S1048891X24016669"],"URL":"https:\/\/doi.org\/10.1136\/ijgc-2023-004435","relation":{},"ISSN":["1048-891X"],"issn-type":[{"value":"1048-891X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prognostic factors in patients with endometrial cancer with isolated lymphatic recurrence","name":"articletitle","label":"Article Title"},{"value":"International Journal of Gynecological Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1136\/ijgc-2023-004435","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 IGCS and ESGO 2023. No commercial re-use. See rights and permissions. Published by BMJ.","name":"copyright","label":"Copyright"}]}}