{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:09:27Z","timestamp":1789168167323,"version":"build-2803163510"},"reference-count":39,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["international-journal-of-gynecological-cancer.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Gynecological Cancer"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1136\/ijgc-2023-005165","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T23:05:16Z","timestamp":1708470316000},"page":"659-666","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Molecular profile is a strong predictor of the pattern of recurrence in patients with endometrial cancer"],"prefix":"10.1016","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6007-0308","authenticated-orcid":false,"given":"Ana","family":"Luzarraga Aznar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Bebia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"L\u00f3pez-Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Villafranca-Magdalena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Salazar-Huayna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Castellvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Col\u00e0s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Gil-Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3164-6686","authenticated-orcid":false,"given":"Silvia","family":"Cabrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1136\/ijgc-2023-005165_bb0010","first-page":"7","article-title":"Cancer statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J Clin"},{"key":"10.1136\/ijgc-2023-005165_bb0015","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1016\/j.ejca.2015.07.022","article-title":"Survival of women with cancers of breast and genital organs in Europe 1999\u20132007: results of the EUROCARE-5 study","volume":"51","author":"Sant","year":"2015","journal-title":"Eur J Cancer"},{"key":"10.1136\/ijgc-2023-005165_bb0020","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1136\/ijgc-2019-000822","article-title":"Clinical outcome of recurrent endometrial cancer: analysis of post-relapse survival by pattern of recurrence and secondary treatment","volume":"30","author":"Legge","year":"2020","journal-title":"Int J Gynecol Cancer"},{"key":"10.1136\/ijgc-2023-005165_bb0025","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1097\/IGC.0000000000001296","article-title":"A proposal for a classification for recurrent endometrial cancer: analysis of a French multicenter database from the FRANCOGYN study group","volume":"28","author":"Bricou","year":"2018","journal-title":"Int J Gynecol Cancer"},{"key":"10.1136\/ijgc-2023-005165_bb0030","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3802\/jgo.2011.22.1.3","article-title":"Multivariate survival analysis of the patients with recurrent endometrial cancer","volume":"22","author":"Odagiri","year":"2011","journal-title":"J Gynecol Oncol"},{"key":"10.1136\/ijgc-2023-005165_bb0035","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ygyno.2019.04.676","article-title":"Recurrent early stage endometrial cancer: patterns of recurrence and results of salvage therapy","volume":"154","author":"Francis","year":"2019","journal-title":"Gynecol Oncol"},{"key":"10.1136\/ijgc-2023-005165_bb0040","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jcma.2015.10.010","article-title":"Pulmonary recurrence in patients with endometrial cancer","volume":"79","author":"Turan","year":"2016","journal-title":"J Chin Med Assoc"},{"key":"10.1136\/ijgc-2023-005165_bb0045","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1006\/gyno.2000.6058","article-title":"Hematogenous dissemination in corpus cancer","volume":"80","author":"Mariani","year":"2001","journal-title":"Gynecol Oncol"},{"key":"10.1136\/ijgc-2023-005165_bb0050","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/0002-9378(85)90371-0","article-title":"Risk factors and recurrent patterns in stage I endometrial cancer","volume":"151","author":"DiSaia","year":"1985","journal-title":"Am J Obstet Gynecol"},{"key":"10.1136\/ijgc-2023-005165_bb0055","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13092052","article-title":"Evaluation of survival, recurrence patterns and adjuvant therapy in surgically staged high-grade endometrial cancer with retroperitoneal metastases","volume":"13","author":"McEachron","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1136\/ijgc-2023-005165_bb0060","doi-asserted-by":"crossref","first-page":"208","DOI":"10.3802\/jgo.2015.26.3.208","article-title":"Lymph node metastasis and pattern of recurrence in clinically early stage endometrial cancer with positive lymphovascular space invasion","volume":"26","author":"Mahdi","year":"2015","journal-title":"J Gynecol Oncol"},{"key":"10.1136\/ijgc-2023-005165_bb0065","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1111\/IGC.0b013e3181a833cc","article-title":"Survival and failure pattern of patients with endometrial cancer after extensive surgery including systematic pelvic and para-aortic lymphadenectomy followed by adjuvant chemotherapy","volume":"19","author":"Watari","year":"2009","journal-title":"Int J Gynecol Cancer"},{"key":"10.1136\/ijgc-2023-005165_bb0070","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1006\/gyno.2001.6550","article-title":"Predictors of lymphatic failure in endometrial cancer","volume":"84","author":"Mariani","year":"2002","journal-title":"Gynecol Oncol"},{"key":"10.1136\/ijgc-2023-005165_bb0075","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/nature12113","article-title":"Integrated genomic characterization of endometrial carcinoma","volume":"497","author":"Cancer Genome Atlas Research Network","year":"2013","journal-title":"Nature"},{"key":"10.1136\/ijgc-2023-005165_bb0080","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/bjc.2015.190","article-title":"A clinically applicable molecular-based classification for endometrial cancers","volume":"113","author":"Talhouk","year":"2015","journal-title":"Br J Cancer"},{"key":"10.1136\/ijgc-2023-005165_bb0085","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/cncr.30496","article-title":"Confirmation of promise: a simple, genomics-based clinical classifier for endometrial cancer","volume":"123","author":"Talhouk","year":"2017","journal-title":"Cancer"},{"key":"10.1136\/ijgc-2023-005165_bb0090","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1093\/annonc\/mdy058","article-title":"Final validation of the promise molecular classifier for endometrial carcinoma in a large population-based case series","volume":"29","author":"Kommoss","year":"2018","journal-title":"Ann Oncol"},{"key":"10.1136\/ijgc-2023-005165_bb0095","doi-asserted-by":"crossref","first-page":"3388","DOI":"10.1200\/JCO.20.00549","article-title":"Molecular classification of the PORTEC-3 trial for high-risk endometrial cancer: impact on prognosis and benefit from adjuvant therapy","volume":"38","author":"Le\u00f3n-Castillo","year":"2020","journal-title":"J Clin Oncol"},{"key":"10.1136\/ijgc-2023-005165_bb0100","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/ijgo.14923","article-title":"FIGO staging of endometrial cancer: 2023","volume":"162","author":"Berek","year":"2023","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1136\/ijgc-2023-005165_bb0105","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1136\/ijgc-2020-002230","article-title":"ESGO\/ESTRO\/ESP guidelines for the management of patients with endometrial carcinoma","volume":"31","author":"Concin","year":"2021","journal-title":"Int J Gynecol Cancer"},{"key":"10.1136\/ijgc-2023-005165_bb0110","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ijgo.2009.02.010","article-title":"Revised FIGO staging for carcinoma of the endometrium","volume":"105","author":"Creasman","year":"2009","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1136\/ijgc-2023-005165_bb0115","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23116266","article-title":"Genomic validation of endometrial cancer patient-derived xenograft models as a preclinical tool","volume":"23","author":"Villafranca-Magdalena","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1136\/ijgc-2023-005165_bb0120","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.ygyno.2022.02.024","article-title":"Time to first recurrence, pattern of recurrence, and survival after recurrence in endometrial cancer according to the molecular classification","volume":"165","author":"Siegenthaler","year":"2022","journal-title":"Gynecol Oncol"},{"key":"10.1136\/ijgc-2023-005165_bb0125","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ygyno.2021.04.029","article-title":"Uterine serous carcinoma","volume":"162","author":"Bogani","year":"2021","journal-title":"Gynecol Oncol"},{"key":"10.1136\/ijgc-2023-005165_bb0130","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1158\/0008-5472.CAN-15-1046","article-title":"Mutant P53 promotes epitelial ovarian cancer by regulating tumor differentiation, metastasis, and responsiveness to steroid hormones","volume":"76","author":"Ren","year":"2016","journal-title":"Cancer Res"},{"key":"10.1136\/ijgc-2023-005165_bb0135","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/modpathol.2015.43","article-title":"Refining prognosis and identifying targetable pathways for high-risk endometrial cancer; a transPORTEC initiative","volume":"28","author":"Stelloo","year":"2015","journal-title":"Mod Pathol"},{"key":"10.1136\/ijgc-2023-005165_bb0140","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1136\/ijgc-2023-004534","article-title":"Endometrial adenocarcinoma recurring in the lung: impact of molecular profile and role of local therapies on prognosis","volume":"33","author":"Luzarraga Aznar","year":"2023","journal-title":"Int J Gynecol Cancer"},{"key":"10.1136\/ijgc-2023-005165_bb0145","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/s41416-018-0187-6","article-title":"L1CAM further stratifier endometrial carcinoma patients with no specific molecular risk profile","volume":"119","author":"Kommoss","year":"2018","journal-title":"Br J Cancer"},{"key":"10.1136\/ijgc-2023-005165_bb0150","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1038\/s41416-023-02141-0","article-title":"Prognostic refinement of NSMP high-risk endometrial cancers using oestrogen receptor immunohistochemistry","volume":"128","author":"Vermij","year":"2023","journal-title":"Br J Cancer"},{"key":"10.1136\/ijgc-2023-005165_bb0155","doi-asserted-by":"crossref","first-page":"100085","DOI":"10.1016\/j.modpat.2022.100085","article-title":"Grade and estrogen receptor expression identify a subset of no specific molecular profile endometrial carcinomas at a very low risk of disease-specific death","volume":"36","author":"Jamieson","year":"2023","journal-title":"Mod Pathol"},{"key":"10.1136\/ijgc-2023-005165_bb0160","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ejca.2023.03.016","article-title":"Back to the future: the impact of oestrogen receptor profile in the era of molecular endometrial cancer classification","volume":"186","author":"Perrone","year":"2023","journal-title":"Eur J Cancer"},{"key":"10.1136\/ijgc-2023-005165_bb0165","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.ygyno.2021.01.002","article-title":"Understanding the clinical implication of mismatch repair deficiency in endometrioid endometrial cancer through a prospective study","volume":"161","author":"Kim","year":"2021","journal-title":"Gynecol Oncol"},{"key":"10.1136\/ijgc-2023-005165_bb0170","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1016\/S0140-6736(00)02139-5","article-title":"Surgery and postoperative radiotherapy versus surgery alone for patients with stage 1 endometrial carcinoma: multicenter randomized trial","volume":"355","author":"Creutzberg","year":"2000","journal-title":"Lancet"},{"key":"10.1136\/ijgc-2023-005165_bb0175","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.ygyno.2003.11.048","article-title":"A phase III trial of surgery with or without adjunctive external beam radiation therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study","volume":"92","author":"Keys","year":"2004","journal-title":"Gynecol Oncol"},{"key":"10.1136\/ijgc-2023-005165_bb0180","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/S0140-6736(09)62163-2","article-title":"Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomized trial","volume":"375","author":"Nout","year":"2010","journal-title":"Lancet"},{"key":"10.1136\/ijgc-2023-005165_bb0185","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1002\/cncr.33516","article-title":"Evaluation of treatment effects in patients with endometrial cancer and POLE mutations: an individual patient data meta-analysis","volume":"127","author":"McAlpine","year":"2021","journal-title":"Cancer"},{"key":"10.1136\/ijgc-2023-005165_bb0190","first-page":"109","article-title":"Refining adjuvant treatment in endometrial cancer based on molecular features: the RAINBO clinical trial program","volume":"33","author":"RAINBO Research Consortium","year":"2022","journal-title":"Int J Gynecol Cancer"},{"key":"10.1136\/ijgc-2023-005165_bb0195","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ygyno.2016.07.090","article-title":"Molecular classification of endometrial carcinoma on diagnostic specimens is highly concordant with final hysterectomy: earlier prognostic information to guide treatment","volume":"143","author":"Talhouk","year":"2016","journal-title":"Gynecol Oncol"},{"key":"10.1136\/ijgc-2023-005165_bb0200","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ygyno.2014.02.012","article-title":"High concordance of molecular tumor alterations between pre-operative curettage and hysterectomy specimens in patients with endometrial carcinoma","volume":"133","author":"Stelloo","year":"2014","journal-title":"Gynecol Oncol"}],"container-title":["International Journal of Gynecological Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1048891X24013896?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1048891X24013896?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/ijgc-2023-005165","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:19:32Z","timestamp":1753229972000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1048891X24013896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["S1048891X24013896"],"URL":"https:\/\/doi.org\/10.1136\/ijgc-2023-005165","relation":{},"ISSN":["1048-891X"],"issn-type":[{"value":"1048-891X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular profile is a strong predictor of the pattern of recurrence in patients with endometrial cancer","name":"articletitle","label":"Article Title"},{"value":"International Journal of Gynecological Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1136\/ijgc-2023-005165","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 IGCS and ESGO 2024. No commercial re-use. See rights and permissions. Published by BMJ.","name":"copyright","label":"Copyright"}]}}