{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:40:39Z","timestamp":1767850839457,"version":"3.49.0"},"reference-count":40,"publisher":"BMJ","issue":"5","funder":[{"name":"CDC","award":["5R49CE003085-02"],"award-info":[{"award-number":["5R49CE003085-02"]}]},{"name":"NIH","award":["UG3\/UH3 DA050173"],"award-info":[{"award-number":["UG3\/UH3 DA050173"]}]},{"DOI":"10.13039\/100009633","name":"NIH\/NICHD","doi-asserted-by":"crossref","award":["5R24HD08714903"],"award-info":[{"award-number":["5R24HD08714903"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100009633","name":"NIH\/NICHD","doi-asserted-by":"crossref","award":["T32HD108054"],"award-info":[{"award-number":["T32HD108054"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Inj Prev"],"accepted":{"date-parts":[[2024,1,8]]},"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Adolescents and young adults with risk factors for opioid misuse and opioid use disorder are at elevated risk for overdose. We examined prior non-fatal overdose experiences among at-risk adolescents\/young adults to inform prevention efforts.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Adolescents\/young adults (ages 16\u201330) in two US emergency departments self-reporting past year opioid misuse or opioid use plus a misuse risk factor completed a baseline survey as part of an ongoing randomised controlled trial. We describe baseline factors associated with (a) overall non-fatal overdose experiences and (b) groups based on substance(s) used during the worst overdose experience.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 771 participants (27.9% male), 40.7% reported a non-fatal overdose experience. Compared with those without a prior overdose experience, those with prior overdose experience(s) were less likely to be heterosexual, and more likely to report a prior suicide attempt and greater peer substance misuse. Regarding the worst overdose experience, substance(s) included: 36.6% alcohol only, 28.0% alcohol and cannabis, 22.6% alcohol with other substance(s) and 12.7% other substance(s) only (eg, opioids). Compared with the alcohol only group, the alcohol and cannabis group were younger and less likely to be heterosexual; the alcohol with other substance(s) group were older and had greater peer substance misuse; and the other substance(s) only group were more likely to be male, receive public assistance, screen positive for anxiety and less likely to be heterosexual.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Among at-risk adolescents\/young adults, findings support the need for tailored overdose prevention efforts based on substance(s) used, with consideration of sexuality, mental health and peer substance use.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registration number<\/jats:title>\n                  <jats:p>\n                     <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT04550715\">NCT04550715<\/jats:ext-link>.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/ip-2023-045072","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T13:25:25Z","timestamp":1707398725000},"page":"373-380","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Lifetime non-fatal overdose experiences among at-risk adolescents and young adults in the emergency department with past-year opioid use in the USA"],"prefix":"10.1136","volume":"30","clinical-trial-number":[{"clinical-trial-number":"nct04550715","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2664-4480","authenticated-orcid":false,"given":"Laura","family":"Seewald","sequence":"first","affiliation":[{"name":"Institute for Firearm Injury Prevention, University of Michigan, Ann Arbor, Michigan, USA"},{"name":"University of Michigan Department of Emergency Medicine, Ann Arbor, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin","family":"Bonar","sequence":"additional","affiliation":[{"name":"University of Michigan Department of Psychiatry, Ann Arbor, Michigan, USA"},{"name":"University of Michigan Addiction Center, Ann Arbor, Michigan, USA"},{"name":"Injury Prevention Center, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy S B","family":"Bohnert","sequence":"additional","affiliation":[{"name":"VA Serious Mental Illness Treatment Resource and Evaluation Center, Ann Arbor, Michigan, USA"},{"name":"University of Michigan Department of Anesthesiology, Ann Arbor, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7605-2980","authenticated-orcid":false,"given":"Patrick M","family":"Carter","sequence":"additional","affiliation":[{"name":"Institute for Firearm Injury Prevention, University of Michigan, Ann Arbor, Michigan, USA"},{"name":"University of Michigan Department of Emergency Medicine, Ann Arbor, Michigan, USA"},{"name":"Injury Prevention Center, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheryl A","family":"King","sequence":"additional","affiliation":[{"name":"University of Michigan Department of Psychiatry, Ann Arbor, Michigan, USA"},{"name":"Injury Prevention Center, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eve D","family":"Losman","sequence":"additional","affiliation":[{"name":"University of Michigan Department of Emergency Medicine, Ann Arbor, Michigan, USA"},{"name":"Injury Prevention Center, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linnea","family":"Bacon","sequence":"additional","affiliation":[{"name":"University of Michigan Department of Psychiatry, Ann Arbor, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiffany","family":"Wheeler","sequence":"additional","affiliation":[{"name":"University of Michigan Department of Psychiatry, Ann Arbor, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maureen","family":"Walton","sequence":"additional","affiliation":[{"name":"Institute for Firearm Injury Prevention, University of Michigan, Ann Arbor, Michigan, USA"},{"name":"University of Michigan Department of Psychiatry, Ann Arbor, Michigan, USA"},{"name":"University of Michigan Addiction Center, Ann Arbor, Michigan, USA"},{"name":"Injury Prevention Center, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,2,8]]},"reference":[{"key":"2025092509431385000_30.5.373.1","unstructured":"CDC National Center for Health Statistics . 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