{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:24:13Z","timestamp":1773660253341,"version":"3.50.1"},"reference-count":44,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2011,7,27]]},"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Aurora kinases are central to cell proliferation and considered to be prognostic\/predictive markers and therapeutic targets for epithelial cancers. Here, the prognostic\/predictive value of Aurora-B protein expression was evaluated in patients with serous, FIGO stage III ovarian carcinomas treated with taxane- or platinum-based first-line chemotherapy (1st-CTx).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Immunohistochemistry was performed on tissue microarrays, including 80 ovarian carcinomas and 18 non-neoplastic ovaries, previously characterised for Aurora-A protein expression. None or marginal (score 0+1), moderate (score 2) and strong (score 3) Aurora-B protein expression was correlated with clinico-pathological parameters as well as recurrence-free survival (RFS) and overall survival (OS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>While non-neoplastic ovaries were negative for Aurora-B, almost all (79\/80; 99%) ovarian carcinomas exhibited Aurora-B positive tumour cells, with score 1 in 41\/80 (51%), score 2 in 23\/80 (29%) and score 3 in 15\/80 (19%) cases. Aurora-B and Aurora-A protein expression correlated significantly (p=0.002). In optimal debulked patients, Aurora-B protein expression was associated with RFS (p=0.011, n=53) and marginally with OS (p=0.460; n=53). Moreover, Aurora-B protein expression was predictive for RFS of optimal debulked patients with taxane-based (p=0.006; n=32), but not with platinum-based (p=0.720; n=20) 1st-CTx. Aurora-B protein expression was not linked to OS in optimal debulked patients with either of the two 1st-CTx.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Aurora-B protein expression frequently occurs in serous, FIGO stage III ovarian carcinomas, making it a \u2018drugable\u2019 molecular target in the majority of ovarian carcinoma patients. Moreover, Aurora-B protein expression is predictive for initial response to taxane-based 1st-CTx in optimal debulked, late stage ovarian carcinoma patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jclinpath-2011-200212","type":"journal-article","created":{"date-parts":[[2011,10,19]],"date-time":"2011-10-19T20:59:07Z","timestamp":1319057947000},"page":"29-35","source":"Crossref","is-referenced-by-count":11,"title":["Aurora-B protein expression is linked to initial response to taxane-based first-line chemotherapy in stage III ovarian carcinoma"],"prefix":"10.1136","volume":"65","author":[{"given":"S","family":"Beussel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Hasenburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Bogatyreva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Hauschke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Werner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Lassmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2011,10,19]]},"reference":[{"key":"2025112109382308000_65.1.29.1","doi-asserted-by":"publisher","DOI":"10.1007\/s004320000153"},{"key":"2025112109382308000_65.1.29.2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2005.00430.x"},{"key":"2025112109382308000_65.1.29.3","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi961"},{"key":"2025112109382308000_65.1.29.4","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000220516.34053.48"},{"key":"2025112109382308000_65.1.29.5","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3253"},{"key":"2025112109382308000_65.1.29.6","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1691"},{"key":"2025112109382308000_65.1.29.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2009.09.019"},{"key":"2025112109382308000_65.1.29.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2009.04.019"},{"key":"2025112109382308000_65.1.29.9","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.8.1.7209"},{"key":"2025112109382308000_65.1.29.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.09.008"},{"key":"2025112109382308000_65.1.29.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2007.01.044"},{"key":"2025112109382308000_65.1.29.12","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-1274"},{"key":"2025112109382308000_65.1.29.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.12.015"},{"key":"2025112109382308000_65.1.29.14","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/emm.2006.38","article-title":"Association between excision repair cross-complementation group 1 polymorphism and clinical outcome of platinum-based chemotherapy in patients with epithelial ovarian cancer","volume":"38","author":"Kang","year":"2006","journal-title":"Exp Mol Med"},{"key":"2025112109382308000_65.1.29.15","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-4076"},{"key":"2025112109382308000_65.1.29.16","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-46091-6_6"},{"key":"2025112109382308000_65.1.29.17","first-page":"60","article-title":"The Aurora kinase family in cell division and cancer","volume":"1786","author":"Vader","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"2025112109382308000_65.1.29.18","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-09-0765"},{"key":"2025112109382308000_65.1.29.19","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2964"},{"key":"2025112109382308000_65.1.29.20","doi-asserted-by":"publisher","DOI":"10.1038\/2496"},{"key":"2025112109382308000_65.1.29.21","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.11.3052"},{"key":"2025112109382308000_65.1.29.22","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2009.111"},{"key":"2025112109382308000_65.1.29.23","first-page":"1420","article-title":"Activation and overexpression of centrosome kinase BTAK\/Aurora-A in human ovarian cancer","volume":"9","author":"Gritsko","year":"2003","journal-title":"Clin Cancer Res"},{"key":"2025112109382308000_65.1.29.24","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-6-79"},{"key":"2025112109382308000_65.1.29.25","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-0431"},{"key":"2025112109382308000_65.1.29.26","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-0671"},{"key":"2025112109382308000_65.1.29.27","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-2775"},{"key":"2025112109382308000_65.1.29.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2008.10.011"},{"key":"2025112109382308000_65.1.29.29","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.10.1.77"},{"key":"2025112109382308000_65.1.29.30","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-2144"},{"key":"2025112109382308000_65.1.29.31","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-010-1318-9"},{"key":"2025112109382308000_65.1.29.32","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(02)00235-0"},{"key":"2025112109382308000_65.1.29.33","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22154"},{"key":"2025112109382308000_65.1.29.34","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-009-0838-3"},{"key":"2025112109382308000_65.1.29.35","doi-asserted-by":"publisher","DOI":"10.1096\/fj.09-130963"},{"key":"2025112109382308000_65.1.29.36","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605274"},{"key":"2025112109382308000_65.1.29.37","unstructured":"Tavassoli FA Deville P . Who Classification of Tumours: Tumours of the Breast and Female Genital Organs. Lyon: IARC Press, 2003."},{"key":"2025112109382308000_65.1.29.38","doi-asserted-by":"crossref","unstructured":"Sobin LH Wittekind C . TNM\u00e2\u0080\u0094Classification of Malignant Tumours, UICC, 6th edn: Hoboken, New Jersey, US: John Wihley and Sons, Inc, 2002.","DOI":"10.1002\/0471463752"},{"key":"2025112109382308000_65.1.29.39","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.5858\/133.11.1775","article-title":"Ovarian cancer update: lessons from morphology, molecules, and mice","volume":"133","author":"Cho","year":"2009","journal-title":"Arch Pathol Lab Med"},{"key":"2025112109382308000_65.1.29.40","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2011.03.003"},{"key":"2025112109382308000_65.1.29.41","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-8-43"},{"key":"2025112109382308000_65.1.29.42","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00612"},{"key":"2025112109382308000_65.1.29.43","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2010.11.029"},{"key":"2025112109382308000_65.1.29.44","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-4922"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jclinpath-2011-200212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:38:30Z","timestamp":1763746710000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jclinpath-2011-200212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,19]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2011,12,13]]},"published-print":{"date-parts":[[2012,1]]}},"alternative-id":["10.1136\/jclinpath-2011-200212"],"URL":"https:\/\/doi.org\/10.1136\/jclinpath-2011-200212","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,19]]}}}