{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:36:30Z","timestamp":1792812990075,"version":"4.5.0"},"reference-count":16,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2011,6,26]]},"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The authors previously reported the expression of keratan sulfate (KS), a glycosaminoglycan, in the epithelium of normal and neoplastic endometria. The aim of this study was to evaluate its potential use as a diagnostic marker, and the expression of KS was investigated in other human epithelial tissues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Expression was examined immunohistochemically using 102 samples of normal epithelia and 110 samples of carcinomas from the female genital tract (FGT; cervix, endometrium, ovary, fallopian tube), digestive organs (gastrointestinal tract, pancreas, liver), urinary tract, lung, mammary gland, thyroid and mesothelium.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In normal tissues, KS was consistently detected in the FGT and ectopic endometrium (25\/26), but was not found in the digestive organs (1\/42) and urinary tract (0\/6), and was only partly detected in the lung (7\/10), mammary gland (3\/9) and thyroid (4\/4). In malignant tissues, KS was consistently observed in carcinomas of the endometrium, ovary and fallopian tube (29\/32), and was partly detected in carcinomas of the lung, mammary gland, thyroid, pancreas and mesothelium, but was absent in carcinomas of the gastrointestinal tract (0\/17), liver (0\/5) and urinary tract (0\/11). Among carcinomas of the FGT, digestive organs and urinary tract, KS positivity suggested the possibility of FGT carcinomas, with 79.5% (31\/39) sensitivity and 92.9% (39\/42) specificity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>KS is a potentially useful marker for the supportive diagnosis of the primary site of metastatic carcinomas or unknown primary carcinomas, especially in the abdominal cavity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jclinpath-2011-200231","type":"journal-article","created":{"date-parts":[[2011,8,12]],"date-time":"2011-08-12T00:21:39Z","timestamp":1313108499000},"page":"1058-1063","source":"Crossref","is-referenced-by-count":18,"title":["Immunohistochemical expression of keratan sulfate: a possible diagnostic marker for carcinomas of the female genital tract"],"prefix":"10.1136","volume":"64","author":[{"given":"Tsutomu","family":"Miyamoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryouichi","family":"Asaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihisa","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Takatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyasu","family":"Kashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanri","family":"Shiozawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2011,8,11]]},"reference":[{"key":"2025120600282943000_64.12.1058.1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M103554200"},{"key":"2025120600282943000_64.12.1058.2","first-page":"5212","article-title":"Tumorigenicity in athymic mice of the human colon carcinoma cell line SW1116 expressing the tumor-associated antigenic determinant CA 19-9","volume":"44","author":"Klug","year":"1984","journal-title":"Cancer Res"},{"key":"2025120600282943000_64.12.1058.3","unstructured":"Esko JD Kimata K Lindahl U . Proteoglycans and sulfated glycosaminoglycans. In: Varki A Cummings RD Esko JD , eds. Essentials of Glycobiology, 2nd edn. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 2009:229\u201348."},{"key":"2025120600282943000_64.12.1058.4","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1159\/000293040","article-title":"Immunohistochemical reactivity of antikeratan sulfate monoclonal antibody 5D4 to various conditions of human endometrial tissues and its application as a useful marker for identifying endometrial epithelia","volume":"32","author":"Shiozawa","year":"1991","journal-title":"Gynecol Obstet Invest"},{"key":"2025120600282943000_64.12.1058.5","doi-asserted-by":"publisher","DOI":"10.1042\/bj2660757"},{"key":"2025120600282943000_64.12.1058.6","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/8.3.269"},{"key":"2025120600282943000_64.12.1058.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.11.059"},{"key":"2025120600282943000_64.12.1058.8","doi-asserted-by":"publisher","DOI":"10.1309\/8VAV-J2FU-8CU9-EK18"},{"key":"2025120600282943000_64.12.1058.9","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-4-38"},{"key":"2025120600282943000_64.12.1058.10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0643.2007.00645.x"},{"key":"2025120600282943000_64.12.1058.11","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990101)85:1<171::AID-CNCR24>3.0.CO;2-V"},{"key":"2025120600282943000_64.12.1058.12","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-2236"},{"key":"2025120600282943000_64.12.1058.13","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20202"},{"key":"2025120600282943000_64.12.1058.14","doi-asserted-by":"publisher","DOI":"10.1097\/01.MP.0000086073.92773.55"},{"key":"2025120600282943000_64.12.1058.15","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960115)77:2<321::AID-CNCR15>3.0.CO;2-3"},{"key":"2025120600282943000_64.12.1058.16","doi-asserted-by":"publisher","DOI":"10.1309\/QLV6-HH0H-UCTF-WEF6"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jclinpath-2011-200231","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T08:28:37Z","timestamp":1765009717000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jclinpath-2011-200231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,11]]},"references-count":16,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2011,11,17]]},"published-print":{"date-parts":[[2011,12]]}},"alternative-id":["10.1136\/jclinpath-2011-200231"],"URL":"https:\/\/doi.org\/10.1136\/jclinpath-2011-200231","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,11]]}}}