{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:46:22Z","timestamp":1790023582825,"version":"4.0.1"},"reference-count":11,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2011,9,26]]},"published-print":{"date-parts":[[2012,3]]},"abstract":"\n Aims<\/jats:title>\n \n To examine the clinicopathological features of a series of penile melanomas and screen for mutations in the\n BRAF<\/jats:italic>\n and\n KIT<\/jats:italic>\n genes, which are seen in melanomas from other sites.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and results<\/jats:title>\n \n 12 patients with penile melanoma were identified over a 10-year period in two supra-regional networks in the UK. The 2- and 5-year survival was 61% and 20%, respectively. Half the patients had lymph node involvement at presentation; this was a poor prognostic indicator.\n KIT<\/jats:italic>\n exons 11, 13, 17 and 18, and\n BRAF<\/jats:italic>\n codons 600 and 601 were analysed for mutations by Sanger sequencing and pyrosequencing, respectively. None of the tumours showed either\n KIT<\/jats:italic>\n mutations or the\n BRAF<\/jats:italic>\n V600E mutation.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Penile melanomas are extremely rare and have a similar prognosis to melanomas elsewhere, but they often present late, leading to a poor outcome. The mutations seen in melanomas from other sites appear to be rarely present in these tumours.<\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/jclinpath-2011-200344","type":"journal-article","created":{"date-parts":[[2011,10,19]],"date-time":"2011-10-19T20:59:07Z","timestamp":1319057947000},"page":"228-231","source":"Crossref","is-referenced-by-count":18,"title":["Clinicopathological and molecular study of penile melanoma"],"prefix":"10.1136","volume":"65","author":[{"given":"J D","family":"Oxley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Corbishley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Down","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Watkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Dickerson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N A C S","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2011,10,19]]},"reference":[{"key":"2025121322490723000_65.3.228.1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.urology.2007.03.039","article-title":"Prognosis of primary mucosal penile melanoma: a series of 19 Dutch patients and 47 patients from the literature","volume":"70","author":"van Geel","year":"2007","journal-title":"Urology"},{"key":"2025121322490723000_65.3.228.2","unstructured":"http:\/\/www.nice.org.uk\/nicemedia\/live\/10889\/28771\/28771.pdf (accessed Jul 2011)."},{"key":"2025121322490723000_65.3.228.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2005.03.015"},{"key":"2025121322490723000_65.3.228.4","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604482"},{"key":"2025121322490723000_65.3.228.5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1002011"},{"key":"2025121322490723000_65.3.228.6","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-2917"},{"key":"2025121322490723000_65.3.228.7","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1111\/j.1365-2559.2007.02866.x","article-title":"KIT and PDGFRalpha mutational analyses of mixed cell-type gastrointestinal stromal tumours","volume":"52","author":"Wong","year":"2007","journal-title":"Histopathology"},{"key":"2025121322490723000_65.3.228.8","doi-asserted-by":"publisher","DOI":"10.1038\/nature00766"},{"key":"2025121322490723000_65.3.228.9","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.2984"},{"issue":"2 Suppl 1","key":"2025121322490723000_65.3.228.10","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1016\/j.urology.2010.03.001","article-title":"Management of the lymph nodes in penile cancer","volume":"76","author":"Heyns","year":"2010","journal-title":"Urology"},{"key":"2025121322490723000_65.3.228.11","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000159207.91737.53"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jclinpath-2011-200344","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T06:49:11Z","timestamp":1765694951000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jclinpath-2011-200344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,19]]},"references-count":11,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,2,17]]},"published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1136\/jclinpath-2011-200344"],"URL":"https:\/\/doi.org\/10.1136\/jclinpath-2011-200344","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,19]]}}}