{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:24:28Z","timestamp":1784823868902,"version":"3.55.0"},"reference-count":29,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2011,10,20]]},"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The biomarkers representing the metastatic potential of well-differentiated thyroid carcinoma remain to be established. A study was undertaken to find whether the expression status of neural cell adhesion molecule (NCAM) and\/or ovarian cancer immunoreactive antigen domain containing 1 (OCIAD1) is associated with the metastatic potential of differentiated thyroid carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>NCAM and OCIAD1 were analysed by immunohistochemistry on tissue microarrays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 214 well-differentiated thyroid carcinomas, 68 patients had distant metastases. Immunohistochemical analyses showed that the majority of benign thyroid lesions expressed NCAM while a significant proportion of thyroid carcinomas lost or had reduced NCAM expression. Both follicular and papillary carcinomas with distant metastasis had a significantly higher frequency of preserving NCAM expression. Hierarchical clustering analysis showed that OCIAD1 had significant differential expression between benign and malignant thyroid lesions. The overall metastatic-to-localised tumour ratio was higher in NCAM-expressing clusters, but the difference between ratios of OCIAD1-positive and OCIAD1-negative subclusters was not significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These analyses suggest that the preservation of NCAM expression in well-differentiated thyroid carcinoma is an indicator for a higher risk of distant metastasis. OCIAD1 is a potential biomarker of thyroid carcinoma but had no significant additive effect on the risk of distant metastasis. Further elucidation of the molecular mechanisms underlying the NCAM-mediated cellular processes will be beneficial for the development of effective treatments against the metastasis of thyroid carcinoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jclinpath-2011-200416","type":"journal-article","created":{"date-parts":[[2011,11,12]],"date-time":"2011-11-12T20:48:40Z","timestamp":1321130920000},"page":"206-212","source":"Crossref","is-referenced-by-count":20,"title":["Expression of NCAM and OCIAD1 in well-differentiated thyroid carcinoma: correlation with the risk of distant metastasis"],"prefix":"10.1136","volume":"65","author":[{"given":"An-Hang","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jui-Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Hsen","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Yi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2011,11,12]]},"reference":[{"key":"2025121321553026000_65.3.206.1","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(03)00332-6"},{"key":"2025121321553026000_65.3.206.2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22956"},{"key":"2025121321553026000_65.3.206.3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02304.x"},{"key":"2025121321553026000_65.3.206.4","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.51.219"},{"key":"2025121321553026000_65.3.206.5","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K08E-116"},{"key":"2025121321553026000_65.3.206.6","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1097\/01.mlg.0000161337.46892.e0","article-title":"Variables predicting distant metastases in thyroid cancer","volume":"115","author":"Clark","year":"2005","journal-title":"Laryngoscope"},{"key":"2025121321553026000_65.3.206.7","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/CCO.0b013e328011ab86","article-title":"Molecular mechanisms involved in differentiated thyroid cancer invasion and metastasis","volume":"19","author":"Vasko","year":"2007","journal-title":"Curr Opin Oncol"},{"key":"2025121321553026000_65.3.206.8","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e32832ff2cb"},{"key":"2025121321553026000_65.3.206.9","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1177\/205873929901200104","article-title":"Protein and mRNA expression of CD56\/N-CAM on follicular epithelial cells of the human thyroid","volume":"12","author":"Zeromski","year":"1999","journal-title":"Int J Immunopathol Pharmacol"},{"key":"2025121321553026000_65.3.206.10","first-page":"246","article-title":"Detection of Leu-19 (CD56) antigen on human thyroid epithelial cells by an immunohistochemical method","volume":"72","author":"Migita","year":"1991","journal-title":"Immunology"},{"key":"2025121321553026000_65.3.206.11","doi-asserted-by":"publisher","DOI":"10.1002\/path.2183"},{"key":"2025121321553026000_65.3.206.12","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-3-5"},{"key":"2025121321553026000_65.3.206.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2008.11.011"},{"key":"2025121321553026000_65.3.206.14","doi-asserted-by":"publisher","DOI":"10.1385\/EP:12:3:291"},{"key":"2025121321553026000_65.3.206.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2007.12.024"},{"key":"2025121321553026000_65.3.206.16","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-09-1024"},{"key":"2025121321553026000_65.3.206.17","unstructured":"DeLellis RA Williams ED . 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