{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T16:39:38Z","timestamp":1783615178799,"version":"3.55.0"},"reference-count":12,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2011,12,1]]},"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:p>\n                    A chronic infectious mononucleosis-like illness caused by Epstein\u2013Barr virus (EBV) is called \u2018chronic active EBV disease\u2019, which is defined as an EBV-associated lymphoproliferative disease. This lymphoproliferative disease is rare and predominantly occurs in Japanese children. Between 1998 and 2010, seven adult-onset cases (aged 20\u201345\u2005years, median 39\u2005years) were identified, which initially presented with inflammatory diseases, including hepatitis, interstitial pneumonitis, uveitis, nephritis and hypersensitivity to mosquito bites. They showed an EBV viral load in the peripheral blood and evidence of EBV infection of T or natural killer (NK) cells. Five cases (71.4%) developed EBV-positive T\/NK-cell lymphoma\/leukaemia at a median of 5\u2005years (range 1\u20137\u2005years) after the diagnosis. Although\n                    <jats:sc>l<\/jats:sc>\n                    -asparaginase-containing chemotherapy was effective for the lymphomas, only allogeneic haematopoietic cell transplantation eradicated EBV-infected cells. This observation indicates that persistent EBV infection of T or NK cells defines a distinct disease entity, which provides an underlying condition for EBV-positive T\/NK-cell lymphoma\/leukaemia.\n                  <\/jats:p>","DOI":"10.1136\/jclinpath-2011-200523","type":"journal-article","created":{"date-parts":[[2012,1,13]],"date-time":"2012-01-13T22:33:11Z","timestamp":1326493991000},"page":"278-282","source":"Crossref","is-referenced-by-count":46,"title":["T\/NK cell type chronic active Epstein\u2013Barr virus disease in adults: an underlying condition for Epstein\u2013Barr virus-associated T\/NK-cell lymphoma"],"prefix":"10.1136","volume":"65","author":[{"given":"Yasushi","family":"Isobe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanae","family":"Aritaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Setoguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuharu","family":"Hamano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Sugimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Komatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2012,1,13]]},"reference":[{"key":"2025112108152487000_65.3.278.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra032015"},{"key":"2025112108152487000_65.3.278.2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.2.280"},{"key":"2025112108152487000_65.3.278.3","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20398"},{"key":"2025112108152487000_65.3.278.4","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-11-316745"},{"key":"2025112108152487000_65.3.278.5","unstructured":"Swerdlow SH Campo E Harris NL . WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th edn. 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