{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T12:08:01Z","timestamp":1759147681273,"version":"3.44.0"},"reference-count":27,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2012,3,2]]},"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p>\n                  <jats:italic>Helicobacter pylori<\/jats:italic> infection is associated with gastroduodenal diseases. Melanoma differentiation associated gene 5 (MDA5) plays a role in antiviral host defense. We investigated the effect of <jats:italic>H pylori<\/jats:italic> infection on MDA5 expression in human gastric mucosa. Biopsy samples from the antrum and corpus were obtained from 33 patients. MDA5 mRNA and protein were examined by real-time PCR and immunohistochemical staining. Histological gastritis was graded according to updated Sydney System. MDA5 mRNA was significantly increased in the antrum infected with <jats:italic>H pylori<\/jats:italic>. MDA5 protein positively stained in infiltrating mononuclear cells. MDA5 mRNA expression was significantly correlated with the grade of glandular atrophy (rs = 0.767) and intestinal metaplasia (rs = 0.748) in the corpus with <jats:italic>H pylori<\/jats:italic> infection. These results indicate that MDA5 may be involved in innate immune reactions against <jats:italic>H pylori<\/jats:italic> and associate with glandular atrophy and intestinal metaplasia in patients with <jats:italic>H pylori<\/jats:italic> infection.<\/jats:p>","DOI":"10.1136\/jclinpath-2011-200590","type":"journal-article","created":{"date-parts":[[2012,3,29]],"date-time":"2012-03-29T23:18:05Z","timestamp":1333063085000},"page":"839-843","source":"Crossref","is-referenced-by-count":14,"title":["Expression of melanoma differentiation associated gene 5 is increased in human gastric mucosa infected with <i>Helicobacter pylori<\/i>"],"prefix":"10.1136","volume":"65","author":[{"given":"Tetsuya","family":"Tatsuta","sequence":"first","affiliation":[{"name":"1Department of Gastroenterology, Hirosaki University Graduate School of Medicine, Hirosaki, 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