{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:48:17Z","timestamp":1760100497698,"version":"3.44.0"},"reference-count":26,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2012,2,16]]},"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>The nuclear factor \u03ba B (NF-\u03baB) family comprises transcription factors that promote the development and progression of cancer. The NF-\u03baB pathway is induced by radiation therapy and may be related to tumour radioresistance. The aim of this study was to evaluate the expression of NF-\u03baB as a predictor of the response to radiotherapy and its value as a prognostic marker.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A retrospective analysis was performed in a series of 32 individuals with stage IB2 and IIB cervical cancer who underwent radiotherapy, followed by radical hysterectomy, from January 1992 to June 2001. NF-\u03baB-p65 and NF-\u03baB-p50 expression was examined by immunohistochemistry in biopsies from all patients before radiotherapy and in 12 patients with residual tumours after radiotherapy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>16 (50%) patients had residual disease after radical hysterectomy. The median follow-up time was 73.5\u2005months, and the 5-year overall survival was 66.5%. Before radiotherapy, cytoplasmic expression of NF-\u03baB-p65 and NF-\u03baB-p50 was noted in 91% and 97% of cases, respectively, versus 59% of cases with nuclear expression of these subunits. Cytoplasmic expression of NF-\u03baB-p65 and NF-\u03baB-p50 in the residual tumours after radiotherapy was observed in 50% of cases; 75% of cases with residual tumours had nuclear expression of NF-\u03baB-p50 versus none with NF-\u03baB-p65. NF-\u03baB-p65 and NF-\u03baB-p50 did not correlate with the risk of residual tumours after radiotherapy or recurrence or death.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>These data suggest that NF-\u03baB does not predict the response to radiotherapy and does not correlate with poor outcomes in advanced cervical cancer.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jclinpath-2011-200599","type":"journal-article","created":{"date-parts":[[2012,3,24]],"date-time":"2012-03-24T03:12:44Z","timestamp":1332558764000},"page":"614-618","source":"Crossref","is-referenced-by-count":5,"title":["Prognostic value of nuclear factor \u03ba B expression in patients with advanced cervical cancer undergoing radiation therapy followed by 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