{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T14:50:57Z","timestamp":1783435857308,"version":"3.54.6"},"reference-count":19,"publisher":"BMJ","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2012,2,20]]},"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>To assess the prevalence of acquired diverticulum of the appendix (DA), including incipient forms and its possible significance as a marker of local\/regional neoplasms.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Materials and Methods<\/jats:title>\n                  <jats:p>The pathology database at Hvidovre Hospital was searched for appendix specimens, received between 2001 and 2010, coded for DA or for a space-occupying lesion. Slides were reviewed to determine DA status and the nature of lesions possibly causing DA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Result<\/jats:title>\n                  <jats:p>Among 4413 appendix specimens, DA were identified in 39 (0.9%, CI 0.6% to 1.2%) cases, 17 (43.6%, 28.0% to 59.2%) of which additionally harboured an appendiceal neoplasm\/neoplastic precursor, whereas this figure was 1.2% (CI 0.9% to 1.6%) for non-DA specimens (p&lt;0.0001). Six of the 39 DA specimens comprised incipient DA, three of which coexisted with appendiceal neoplasms. In addition, local\/regional non-neoplastic lesions (six cases) and colorectal carcinomas (four cases) coexisted with DA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>DA has significance as a putative marker of local\/regional neoplasms. Therefore, a DA specimen proved significantly more likely to harbour a neoplastic growth than a non-DA counterpart. Submission for microscopy of the entire DA specimen, whether transmural or only incipient, and a comment in the pathology report on the occasional concurrence of local\/regional neoplasms in this setting seem appropriate. The observation of DA may thus provide a valuable contribution in the diagnostic process.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jclinpath-2011-200647","type":"journal-article","created":{"date-parts":[[2012,3,29]],"date-time":"2012-03-29T23:18:05Z","timestamp":1333063085000},"page":"638-642","source":"Crossref","is-referenced-by-count":27,"title":["Significance of acquired diverticular disease of the vermiform appendix: a marker of regional neoplasms?"],"prefix":"10.1136","volume":"65","author":[{"given":"Klaus","family":"Kallenbach","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie Vetli","family":"Hjorth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulla","family":"Engel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nis Hallundb\u00e6k","family":"Schlesinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Holck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2012,3,29]]},"reference":[{"key":"2025092505105842000_65.7.638.1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880086"},{"key":"2025092505105842000_65.7.638.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2008.06.001"},{"key":"2025092505105842000_65.7.638.3","doi-asserted-by":"publisher","DOI":"10.1177\/1066896909332728"},{"key":"2025092505105842000_65.7.638.4","doi-asserted-by":"publisher","DOI":"10.1007\/BF02553377"},{"key":"2025092505105842000_65.7.638.5","doi-asserted-by":"publisher","DOI":"10.1177\/106689699800600106"},{"key":"2025092505105842000_65.7.638.6","doi-asserted-by":"publisher","DOI":"10.1007\/BF02588104"},{"key":"2025092505105842000_65.7.638.7","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0046-8177(87)80197-1","article-title":"Diverticulosis of the vermiform appendix in patients with cystic fibrosis","volume":"18","author":"Georg","year":"1987","journal-title":"Hum Pathol"},{"key":"2025092505105842000_65.7.638.8","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181abe31b"},{"key":"2025092505105842000_65.7.638.9","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2004.11.006"},{"key":"2025092505105842000_65.7.638.10","first-page":"314","article-title":"Unusual tumors of the appendix and pseudomyxoma peritonei","volume":"13","author":"Carr","year":"1996","journal-title":"Semin Diagn Pathol"},{"key":"2025092505105842000_65.7.638.11","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181af6067"},{"key":"2025092505105842000_65.7.638.12","first-page":"548","article-title":"Mucoceles of the appendix. Their relationship to hyperplastic polyps, mucinous cystadenomas, and cystadenocarcinomas","volume":"99","author":"Quizilbach","year":"1975","journal-title":"Arch Pathol Lab Med"},{"key":"2025092505105842000_65.7.638.13","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31817ec31e"},{"key":"2025092505105842000_65.7.638.14","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200308000-00006"},{"key":"2025092505105842000_65.7.638.15","doi-asserted-by":"publisher","DOI":"10.1309\/BF5KLH7J547AXAA0"},{"issue":"Suppl 1","key":"2025092505105842000_65.7.638.16","first-page":"146A","article-title":"Appendiceal serrated neoplasms are more frequently associated with right-sided than left-sided colorectal adenocarcinoma","volume":"24","author":"Davison","year":"2011","journal-title":"Mod Pathol"},{"key":"2025092505105842000_65.7.638.17","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31806bee6d"},{"key":"2025092505105842000_65.7.638.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2011.05.003"},{"key":"2025092505105842000_65.7.638.19","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2004.018317"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jclinpath-2011-200647","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T12:11:02Z","timestamp":1758802262000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jclinpath-2011-200647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,29]]},"references-count":19,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2012,6,28]]},"published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1136\/jclinpath-2011-200647"],"URL":"https:\/\/doi.org\/10.1136\/jclinpath-2011-200647","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,29]]}}}