{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:24:42Z","timestamp":1763036682385,"version":"3.44.0"},"reference-count":27,"publisher":"BMJ","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2012,4,10]]},"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:sec>\n                  <jats:title>Backgrounds<\/jats:title>\n                  <jats:p>Large cell neuroendocrine carcinoma (LCNEC) is well-known as a lung cancer subtype. This study assessed the prevalence of head and neck mucosal LCNEC (M-LCNEC).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>M-LCNEC was studied clinically, histologically and immunohistochemically.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 814 surgically resected cases of mucosal head and neck carcinoma, only eight cases (0.98%; all men, mean age 64.6\u2005years) were rediagnosed as M-LCNEC. They occurred in the oropharynx (n=3), larynx (n=4) and hypopharynx (n=1). Seven of the cases had regional lymph node metastases and four resulted in death. Histologically, M-LCNEC had a sheet-like trabacular organoid growth pattern of relatively large basaloid cells in which central necrosis, rosette formation, peripheral palisading and high mitotic figures were evident. M-LCNEC was immunopositive for two or three neuroendocrine markers (CD56, chromogranin-A and synaptophysin). All cases showed high proliferative activity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>M-LCNEC in the head and neck regions is a distinct histopathological entity whose positivity for neuroendocrine markers makes its diagnosis important. As about half of the patients died of the disease, M-LCNEC has a relatively poor prognosis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jclinpath-2012-200801","type":"journal-article","created":{"date-parts":[[2012,6,21]],"date-time":"2012-06-21T09:21:18Z","timestamp":1340270478000},"page":"704-709","source":"Crossref","is-referenced-by-count":37,"title":["Mucosal large cell neuroendocrine carcinoma of the head and neck regions in Japanese patients: a distinct clinicopathological entity"],"prefix":"10.1136","volume":"65","author":[{"given":"Kimihide","family":"Kusafuka","sequence":"first","affiliation":[{"name":"1Pathology Division, Shizuoka Cancer Center Hospital and Research Institute, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Abe","sequence":"additional","affiliation":[{"name":"1Pathology Division, Shizuoka Cancer Center Hospital and Research Institute, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Iida","sequence":"additional","affiliation":[{"name":"2Division of Head and Neck Surgery, Shizuoka Cancer Center Hospital and Research Institute, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuro","family":"Onitsuka","sequence":"additional","affiliation":[{"name":"2Division of Head and Neck Surgery, Shizuoka Cancer Center Hospital and Research Institute, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohito","family":"Fuke","sequence":"additional","affiliation":[{"name":"2Division of Head and Neck Surgery, Shizuoka Cancer Center Hospital and Research Institute, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rei","family":"Asano","sequence":"additional","affiliation":[{"name":"2Division of Head and Neck Surgery, Shizuoka Cancer Center Hospital and Research Institute, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Kamijo","sequence":"additional","affiliation":[{"name":"2Division of Head and Neck Surgery, Shizuoka Cancer Center Hospital and Research Institute, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Nakajima","sequence":"additional","affiliation":[{"name":"1Pathology Division, Shizuoka Cancer Center Hospital and Research Institute, Shizuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2012,6,20]]},"reference":[{"key":"2025092509565657000_65.8.704.1","unstructured":"Brambilla E Pugatch B Geisinger K . 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