{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T06:11:23Z","timestamp":1776319883576,"version":"3.50.1"},"reference-count":21,"publisher":"BMJ","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2012,6,24]]},"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Bioglue is an adhesive used during cardiovascular surgery to improve hemostasis perioperatively and to strengthen and reinforce vascular anastomoses. It has also been used to \u2018seal\u2019 the false lumen in patients presenting with acute aortic dissections. Herein, we examine the complications of Bioglue, which may lead to redo sternotomy in selected patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A review of pathology records at our institution from 2002 to 2010 found 4 cases of excised aortic tissue and\/or aortic valves with previous Bioglue\u00ae use at initial operation. Excised tissues and valves were examined, looking for the presence of Bioglue\u00ae, inflammatory cells (acute, chronic, macrophage and giant cells) and micro-organisms. Patient demographics were also reviewed and recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified four cases of Bioglue use found at redo surgery, after the formation of pseudoaneurysm (n=3) and aortic stenosis (n=1). Mean interval to redo surgery was 2.28 + 0.32 years (range 2-2.6 years). Pseudoaneurysm formation was thought to be caused by an inflammatory reaction to the Bioglue\u00ae itself in two cases, while one case found no such reaction. One patient with previous aortic valve replacement had large annular abscesses filled with necrotic debris surrounding the prosthesis and pannus found on the sewing cuff, comprised of Bioglue\u00ae itself.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The mechanisms leading to these complications include mechanical strain, inflammation and tissue necrosis. The judicious use of Bioglue\u00ae when clinically indicated, and close follow-up of these patients with serial imaging, remain an integral part of avoiding future complications.<\/jats:p><\/jats:sec>","DOI":"10.1136\/jclinpath-2012-200809","type":"journal-article","created":{"date-parts":[[2012,8,8]],"date-time":"2012-08-08T03:58:41Z","timestamp":1344398321000},"page":"1008-1012","source":"Crossref","is-referenced-by-count":47,"title":["Complications of Bioglue postsurgery for aortic dissections and aortic valve replacement"],"prefix":"10.1136","volume":"65","author":[{"given":"Adriana","family":"Luk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tirone E","family":"David","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jagdish","family":"Butany","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2012,8,7]]},"reference":[{"key":"2024052923442076000_65.11.1008.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2005.02.004"},{"key":"2024052923442076000_65.11.1008.2","doi-asserted-by":"crossref","unstructured":"Zehr KJ . Use of bovine albumin-glutaraldehyde glue in cardiovascular surgery. Ann Thorac Surg 2007;84:1048\u201352.","DOI":"10.1016\/j.athoracsur.2007.01.012"},{"key":"2024052923442076000_65.11.1008.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.11.054"},{"key":"2024052923442076000_65.11.1008.4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8191.2009.00809.x"},{"key":"2024052923442076000_65.11.1008.5","first-page":"581","article-title":"\u201cBioglue\u201d as a possible cause of acute blocked mechanical mitral valve leaflet","volume":"47","author":"Shapira","year":"2006","journal-title":"J Cardiovasc Surg (Torino)"},{"key":"2024052923442076000_65.11.1008.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.12.069"},{"key":"2024052923442076000_65.11.1008.7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8191.2011.01208.x"},{"key":"2024052923442076000_65.11.1008.8","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2010.261933"},{"key":"2024052923442076000_65.11.1008.9","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1249868"},{"key":"2024052923442076000_65.11.1008.10","unstructured":"Food and Drug Administration Center for Devices and Radiological Health. Bioglue surgical adhesive approval Order. 2001. http:\/\/www.accessdata.fda.gov\/scripts\/cdrh\/cfdocs\/cftopic\/pma\/pma.cfm?num=p010003 (accessed 21 May 2011)."},{"key":"2024052923442076000_65.11.1008.11","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(03)00376-4"},{"key":"2024052923442076000_65.11.1008.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(02)03689-5"},{"key":"2024052923442076000_65.11.1008.13","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(01)02777-1"},{"key":"2024052923442076000_65.11.1008.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2004.07.046"},{"key":"2024052923442076000_65.11.1008.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.12.072"},{"key":"2024052923442076000_65.11.1008.16","unstructured":"Weiner J Widman S Golek Z . Bioglue does not predispose to anastomotic pseudoaneurysm in thoracic aortic surgery. Presented at 15th World Congress on Heart Disease, Vancouver, British Colombia, Canada July 2010."},{"key":"2024052923442076000_65.11.1008.17","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(95)97585-B"},{"key":"2024052923442076000_65.11.1008.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2004.04.033"},{"key":"2024052923442076000_65.11.1008.19","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2011.273094"},{"key":"2024052923442076000_65.11.1008.20","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jvs.2004.06.014","article-title":"Embolus of surgical adjesive to the extremities causing acute ischemia: report of two cases","volume":"40","author":"Guerrero","year":"2003","journal-title":"J Vasc Surg"},{"key":"2024052923442076000_65.11.1008.21","unstructured":"Cryolife: Products and Services, Bioglue\u00ae Surgical Adhesive. http:\/\/www.cryolife.com\/products\/bioglue-surgical-adhesive (accessed 21 May 2011)."}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jclinpath-2012-200809","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T12:35:33Z","timestamp":1717072533000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jclinpath-2012-200809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,7]]},"references-count":21,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2012,10,17]]},"published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1136\/jclinpath-2012-200809"],"URL":"https:\/\/doi.org\/10.1136\/jclinpath-2012-200809","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,7]]}}}