{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:18:34Z","timestamp":1758845914733,"version":"3.44.0"},"reference-count":23,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2012,5,8]]},"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Studies on the role of duodenal bulb biopsy (DBB) in coeliac disease (CD) evaluation have increased in recent years; growing evidence suggests that the disease can present solely in the duodenal bulb. Moreover, recent CD guidelines recommend obtaining a DBB. The study aim was to examine DBB performance in children undergoing CD evaluation and to identify independent predictors of DBB performance.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The authors performed a structured chart review of children aged &lt;18\u2005years who underwent CD evaluation between 2000 and 2010 at a large teaching hospital. The authors collected data including demographics, serology, endoscopy and histopathological findings. Predictors of DBB performance (obtained vs not obtained) were determined using multivariable logistic regression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 616 children who underwent endoscopy, DBB was performed in 103 children (17%, 95% CI 14% to 20%) with an increasing trend in the more recent years (2008\u20132010, 25%; 2004\u20132007, 16%; and 2000\u20132003, 5%, p&lt;0.001). Three independent predictors of DBB performance were older age at endoscopy (OR 1.05 per year of age), gross gastric antral abnormalities (OR 2.81) and gross duodenal abnormalities (OR 5.55). Regarding the DBB histological findings, patchiness of CD was found in 15%. Positive Marsh III biopsy presented solely on the DBB in 6\/103 (6%, 95% CI 2% to 12%) children.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The authors found a significant increase in DBB performance over time, but the overall performance remains suboptimal. Improving education on obtaining a DBB for CD evaluation is crucial, especially among those children in whom DBB is more likely to be omitted.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jclinpath-2012-200874","type":"journal-article","created":{"date-parts":[[2012,6,21]],"date-time":"2012-06-21T09:21:18Z","timestamp":1340270478000},"page":"791-794","source":"Crossref","is-referenced-by-count":7,"title":["Predictors of duodenal bulb biopsy performance in the evaluation of coeliac disease in children"],"prefix":"10.1136","volume":"65","author":[{"given":"Pornthep","family":"Tanpowpong","sequence":"first","affiliation":[{"name":"1Department of Pediatrics, Massachusetts General Hospital for Children, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarabeth","family":"Broder-Fingert","sequence":"additional","affiliation":[{"name":"1Department of Pediatrics, Massachusetts General Hospital for Children, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aubrey J","family":"Katz","sequence":"additional","affiliation":[{"name":"1Department of Pediatrics, Massachusetts General Hospital for Children, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Carlos A","family":"Camargo","sequence":"additional","affiliation":[{"name":"2Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2012,6,20]]},"reference":[{"key":"2025092506261382000_65.9.791.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071600"},{"key":"2025092506261382000_65.9.791.2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-2373"},{"key":"2025092506261382000_65.9.791.3","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.3.286"},{"key":"2025092506261382000_65.9.791.4","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181e04d26"},{"key":"2025092506261382000_65.9.791.5","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.153"},{"key":"2025092506261382000_65.9.791.6","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-010-0008-3"},{"key":"2025092506261382000_65.9.791.7","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.557"},{"key":"2025092506261382000_65.9.791.8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.40669.x"},{"key":"2025092506261382000_65.9.791.9","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31822d31da"},{"key":"2025092506261382000_65.9.791.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2010.05.021"},{"key":"2025092506261382000_65.9.791.11","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181677d6e"},{"key":"2025092506261382000_65.9.791.12","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200402000-00019"},{"key":"2025092506261382000_65.9.791.13","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31821a23d0"},{"key":"2025092506261382000_65.9.791.14","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1320"},{"key":"2025092506261382000_65.9.791.15","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.03.059"},{"key":"2025092506261382000_65.9.791.16","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1097\/00042737-199910000-00019","article-title":"The histopathology of coeliac disease: time for a standardized report scheme for pathologists","volume":"11","author":"Oberhuber","year":"1999","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2025092506261382000_65.9.791.17","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/0016-5085(92)91819-P","article-title":"Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity (\u2018celiac sprue\u2019)","volume":"102","author":"Marsh","year":"1992","journal-title":"Gastroenterology"},{"key":"2025092506261382000_65.9.791.18","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.171"},{"key":"2025092506261382000_65.9.791.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2010.06.026"},{"key":"2025092506261382000_65.9.791.20","doi-asserted-by":"publisher","DOI":"10.2350\/10-05-0833-OA.1"},{"key":"2025092506261382000_65.9.791.21","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(94)70254-3"},{"key":"2025092506261382000_65.9.791.22","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2005.035345"},{"key":"2025092506261382000_65.9.791.23","first-page":"335","article-title":"Diagnostic value of endoscopic markers for celiac disease in adults: a multicentre prospective Italian study","volume":"54","author":"Piazzi","year":"2008","journal-title":"Minerva Gastroenterol Dietol"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jclinpath-2012-200874","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T13:26:17Z","timestamp":1758806777000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jclinpath-2012-200874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,20]]},"references-count":23,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2012,8,28]]},"published-print":{"date-parts":[[2012,9]]}},"alternative-id":["10.1136\/jclinpath-2012-200874"],"URL":"https:\/\/doi.org\/10.1136\/jclinpath-2012-200874","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[2012,6,20]]}}}