{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T19:50:50Z","timestamp":1783540250396,"version":"3.55.0"},"reference-count":39,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2012,11,15]]},"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Acute <jats:italic>Helicobacter pylori<\/jats:italic> infection is associated with transient hypochlorhydria. In <jats:italic>H pylori-<\/jats:italic>associated atrophy, hypochlorhydria has a role in iron deficiency (ID) through changes in the physiology of iron-complex absorption. The aims were to evaluate the association between <jats:italic>H pylori-<\/jats:italic>associated hypochlorhydria and ID in children.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Symptomatic children (n=123) were prospectively enrolled. Blood, gastric juice and gastric biopsies were taken, respectively, for haematological analyses, pH assessment and <jats:italic>H pylori<\/jats:italic> determination, and duodenal biopsies for exclusion of coeliac disease. Stool samples were collected for parasitology\/microbiology. Thirteen children were excluded following parasitology and duodenal histopathology, and five due to impaired blood analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Ten children were hypochlorhydric (pH&gt;4) and 33 were <jats:italic>H pylori<\/jats:italic> positive. In <jats:italic>H pylori-<\/jats:italic>positive children with pH&gt;4 (n=6) serum iron and transferrin saturation levels % were significantly lower (p&lt;0.01) than <jats:italic>H pylori-<\/jats:italic>positive children with pH\u22644. No differences in ferritin, or total iron binding capacity, were observed. In <jats:italic>H pylori-<\/jats:italic>negative children with pH&gt;4, iron and transferrin saturation were not significantly different from children with pH\u22644.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Low serum iron and transferrin in childhood <jats:italic>H pylori<\/jats:italic> infection is associated with hypochlorhydria. In uninfected children, hypochlorhydria was not associated with altered serum iron parameters, indicating a combination of <jats:italic>H pylori<\/jats:italic> infection and\/or inflammation, and hypochlorhydria has a role in the aetiology of ID. Although <jats:italic>H pylori-<\/jats:italic>associated hypochlorhydria is transient during acute gastritis, this alters iron homeostasis with clinical impact in developing countries with a high <jats:italic>H pylori<\/jats:italic> prevalence.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jclinpath-2012-201243","type":"journal-article","created":{"date-parts":[[2012,12,25]],"date-time":"2012-12-25T20:26:03Z","timestamp":1356467163000},"page":"343-347","source":"Crossref","is-referenced-by-count":35,"title":["<i>Helicobacter pylori<\/i>-associated hypochlorhydria in children, and development of iron deficiency"],"prefix":"10.1136","volume":"66","author":[{"given":"Paul R","family":"Harris","sequence":"first","affiliation":[{"name":"Division of Paediatrics, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina 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