{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:32:16Z","timestamp":1761489136169,"version":"3.44.0"},"reference-count":16,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2013,3,26]]},"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To investigate the pathological and clinical meaning of p63 in extranodal nasal type NK\/T cell lymphoma (NKTCL).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We detected p63 and p53 expression using immunohistochemistry staining in 84 cases of NKTCL from Southern of China, an area with a well known high incidence of nasopharyngeal carcinoma, which is closely associated with Epstein\u2013Barr virus infection. Moreover, we analysed the relationship between p63 and p53 expression and the clinicopathological features of NKTCL.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Our results first showed that p63 expression was found in 14.3% (12\/84) of NKTCL compared with 6.6% (2\/30) in reactive lymphoid hyperplasia of nasopharynx. p63 Expression rate in NKTCL was significantly higher than that in reactive lymphoid hyperplasia of nasopharynx (p=0.016). NKTCL patients with p63 positivity had poorer 5-year overall survival rate (29.2%) than that (49.9%) of p63 negativity. p53 expression was found in 33.3% (28\/84) of NKTCL. Our data showed that p53 expression was significantly associated with tumour stage (p=0.016) and international prognostic index (p=0.026) in patients with NKTCL. Cox regression test showed that p53 expression rate and international prognostic index score were statistically independent prognostic factors for NKTCL patients (p=0.002 and p=0.016, respectively). Our results suggest that p63 and p53 might play a role in pathogenesis of NKTCL.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jclinpath-2013-201454","type":"journal-article","created":{"date-parts":[[2013,4,27]],"date-time":"2013-04-27T20:20:14Z","timestamp":1367094014000},"page":"676-680","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["p63 And p53 expression in extranodal NK\/T cell lymphoma, nasal type"],"prefix":"10.1136","volume":"66","author":[{"given":"Ziyin","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Pathology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinghua","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Pathology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingjie","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Pathology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongdong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Jiang","sequence":"additional","affiliation":[{"name":"Undergraduate student (Grade 2008), Department of Clinical Medicine, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoling","family":"Yu","sequence":"additional","affiliation":[{"name":"Undergraduate student (Grade 2008), Department of Clinical Medicine, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjia","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Pathology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2013,4,27]]},"reference":[{"key":"2025092504264155000_66.8.676.1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/ijc.2910440112","article-title":"Nation-wide study of lethal mid-line granuloma in Japan: frequencies of wegener's granulomatosis, polymorphic reticulosis, malignant lymphoma and other related conditions","volume":"44","author":"Aozasa","year":"1989","journal-title":"Int J Cancer"},{"key":"2025092504264155000_66.8.676.2","doi-asserted-by":"crossref","unstructured":"Sato Y Tsurumi T . 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WHO classification of tumours, pathology & genetics tumours of haematopoietic and lymphoid tissues. Lyon: IARC Press, 2008."},{"key":"2025092504264155000_66.8.676.15","first-page":"494","article-title":"p63 expression profiles in human normal and tumor tissues","volume":"8","author":"Di Como","year":"2002","journal-title":"Clin Cancer Res"},{"key":"2025092504264155000_66.8.676.16","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e3181edf543"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jclinpath-2013-201454","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T11:26:48Z","timestamp":1758799608000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jclinpath-2013-201454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,27]]},"references-count":16,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2013,7,22]]},"published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1136\/jclinpath-2013-201454"],"URL":"https:\/\/doi.org\/10.1136\/jclinpath-2013-201454","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[2013,4,27]]}}}