{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T15:36:41Z","timestamp":1765294601124,"version":"3.45.0"},"reference-count":23,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2013,5,12]]},"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Stanniocalcin-1 (STC1) is involved in fundamental biological processes such as angiogenesis, inflammation and wound healing, but little is known about its expression in human coronary atherosclerotic plaques or its relationship to plaque instability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>STC1 expression was examined in the culprit coronary plaques of 70 patients with acute myocardial infarction (AMI; n=49) or stable angina (n=21) who underwent directional coronary atherectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The specimens were stained with H&amp;E, STC1-specific antibodies, and endothelial cells, macrophages and smooth muscle cell markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The baseline characteristics of the two groups of patients were largely similar. CD31-immunopositive and CD68-immunopositive areas, indicative of the presence of endothelial cells and macrophages, respectively, were proportionately larger while areas immunopositive for \u03b1-actin, as a smooth muscle cell marker, were proportionately smaller in the AMI group than in the stable angina group. The proportion of STC1-immunopositive areas was significantly greater in the AMI group than in the stable angina group (20.0% (8.2\u201329.0%) vs 8.8% (3.9\u201319.4%), p=0.022). Areas positive for STC1 were independently correlated with those immunopositive for CD31 (r=0.42, p&lt;0.001) and CD68 (r=0.40, p&lt;0.001). STC1 immunoreactivity co-localised with CD31-immunopositive and CD68-immunopositive cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>STC1 is differentially expressed in the culprit coronary plaques of patients with AMI versus those with stable angina. STC1 may play a role in plaque instability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jclinpath-2013-201563","type":"journal-article","created":{"date-parts":[[2013,6,11]],"date-time":"2013-06-11T23:27:12Z","timestamp":1370993232000},"page":"787-791","source":"Crossref","is-referenced-by-count":7,"title":["Expression of stanniocalcin-1 in culprit coronary plaques of patients with acute myocardial infarction or stable angina"],"prefix":"10.1136","volume":"66","author":[{"given":"Cheol Whan","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Cardiology, Heart Institute, Asan Medical Center, University of Ulsan, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilseon","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, Keimyung University, Choong-Ku, Daegu, 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