{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:04:56Z","timestamp":1792087496262,"version":"4.4.0"},"reference-count":25,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2013,9,2]]},"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The aim of this study was to evaluate the epithelial\u2013mesenchymal transition (EMT) and to assess its prognostic significance in intrahepatic cholangiocarcinoma.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We performed immunohistochemical stainings for E-cadherin, \u03b2-catenin, vimentin and fibronectin in a total of 85 cases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Expression of vimentin and reduced expression of E-cadherin were found to show correlation with poor differentiation (p=0.017, p=0.010). Reduced expression of \u03b2-catenin showed significant association with poor differentiation (p=0.023), tumour size (p=0.028) and lymph node metastasis (p=0.011). According to the expression pattern of E-cadherin, \u03b2-catenin, vimentin and fibronectin we categorised four phenotypes: complete type, hybrid type, null type and wild type. The complete type of \u03b2-catenin with vimentin or fibronectin was found to show an association with lymph node metastasis (p=0.048, p=0.012). Significantly worse overall survival (OS) and disease-free survival (DFS) was observed for the complete type, and the best OS and DFS were observed for the wild type.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>EMT phenotypes can be useful markers for prediction of patient outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jclinpath-2013-201806","type":"journal-article","created":{"date-parts":[[2013,9,24]],"date-time":"2013-09-24T03:15:06Z","timestamp":1379992506000},"page":"229-234","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Epithelial\u2013mesenchymal transition phenotypes are associated with patient survival in intrahepatic cholangiocarcinoma"],"prefix":"10.1136","volume":"67","author":[{"given":"Mi Jin","family":"Gu","sequence":"first","affiliation":[{"name":"Department of Pathology, Yeungnam University College of Medicine, Daegu, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon Hyuk","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Yeungnam University College of Medicine, Daegu, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2013,9,23]]},"reference":[{"key":"2025092505312347000_67.3.229.1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604129"},{"key":"2025092505312347000_67.3.229.2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-10-302"},{"key":"2025092505312347000_67.3.229.3","doi-asserted-by":"publisher","DOI":"10.1159\/000084509"},{"key":"2025092505312347000_67.3.229.4","first-page":"4451","article-title":"The EMT status in the primary tumor does not predict postoperative recurrence or disease-free survival in lung adenocarcinoma","volume":"31","author":"Chikaishi","year":"2011","journal-title":"Anticancer Res"},{"key":"2025092505312347000_67.3.229.5","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.59"},{"key":"2025092505312347000_67.3.229.6","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27467"},{"key":"2025092505312347000_67.3.229.7","first-page":"973","article-title":"Immunohistochemical and mutational analyses of wnt signaling components and target genes in intrahepatic cholangiocarcinomas","volume":"27","author":"Tokumoto","year":"2005","journal-title":"Int J Oncol"},{"key":"2025092505312347000_67.3.229.8","doi-asserted-by":"publisher","DOI":"10.1038\/nrc822"},{"key":"2025092505312347000_67.3.229.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2012.05.011"},{"key":"2025092505312347000_67.3.229.10","first-page":"1235","article-title":"Vimentin expression is associated with decreased survival in gastric cancer","volume":"25","author":"Otsuki","year":"2011","journal-title":"Oncol Rep"},{"key":"2025092505312347000_67.3.229.11","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgs227"},{"key":"2025092505312347000_67.3.229.12","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-10-0490"},{"key":"2025092505312347000_67.3.229.13","first-page":"787","article-title":"Fibronectin 1 protein expression in clear cell renal cell carcinoma","volume":"3","author":"Steffens","year":"2012","journal-title":"Oncol Lett"},{"key":"2025092505312347000_67.3.229.14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1115191108"},{"key":"2025092505312347000_67.3.229.15","first-page":"237","article-title":"Bcl-2 and P53 oncoprotein expression during colorectal tumorigenesis","volume":"55","author":"Sinicrope","year":"1995","journal-title":"Cancer Res"},{"key":"2025092505312347000_67.3.229.16","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-29-88"},{"key":"2025092505312347000_67.3.229.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2005.08.001"},{"key":"2025092505312347000_67.3.229.18","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5742(03)00033-4"},{"key":"2025092505312347000_67.3.229.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2008.07.013"},{"key":"2025092505312347000_67.3.229.20","first-page":"2279","article-title":"Aberrant expression of vimentin correlates with dedifferentiation and poor prognosis in patients with intrahepatic cholangiocarcinoma","volume":"30","author":"Korita","year":"2010","journal-title":"Anticancer Res"},{"key":"2025092505312347000_67.3.229.21","doi-asserted-by":"crossref","unstructured":"Sudo T Iwaya T Nishida N . Expression of mesenchymal markers vimentin and fibronectin: The clinical significance in esophageal squamous cell carcinoma. Ann Surg Oncol 2012. doi: 10.1245\/s10434-012-2418-z","DOI":"10.1245\/s10434-012-2418-z"},{"key":"2025092505312347000_67.3.229.22","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-0487"},{"key":"2025092505312347000_67.3.229.23","first-page":"1523","article-title":"Molecular mechanisms involved in the pathogenesis of gastric carcinoma: Interactions between genetic alterations, cellular phenotype and cancer histotype","volume":"48","author":"Fiocca","year":"2001","journal-title":"Hepatogastroenterology"},{"key":"2025092505312347000_67.3.229.24","first-page":"1241","article-title":"Clinicopathological significance of E-cadherin, beta-catenin and epidermal growth factor receptor expression in intrahepatic cholangiocarcinoma","volume":"59","author":"Gu","year":"2012","journal-title":"Hepatogastroenterology"},{"key":"2025092505312347000_67.3.229.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2011.07.003"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jclinpath-2013-201806","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T12:31:30Z","timestamp":1758803490000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jclinpath-2013-201806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,23]]},"references-count":25,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,2,14]]},"published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1136\/jclinpath-2013-201806"],"URL":"https:\/\/doi.org\/10.1136\/jclinpath-2013-201806","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,23]]}}}