{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T01:26:20Z","timestamp":1781918780474,"version":"3.54.5"},"reference-count":12,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2013,10,24]]},"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:p>Type AB thymoma is a thymic epithelial tumour composed of lymphocyte-poor type A and lymphocyte-rich type B components. Although it is categorised as a single entity in the classification of WHO, it shows a broad range of morphology. To investigate whether the functional characteristic of neoplastic cells in type AB thymoma relates to morphological diversity, we performed immunohistochemical analysis using anti-\u03b25t antibody in 20 cases of type AB thymoma. \u03b25t is a recently discovered proteasomal \u03b2 subunit expressed exclusively in cortical thymic epithelial cells and tumour epithelial cells of thymomas with cortical differentiation. Consistent with our previous observation, \u03b25t was predominantly expressed in the type B component. When the type B component was divided into three groups morphologically, \u03b25t was expressed more frequently in cases with round to polygonal than spindle to oval tumour cells. Furthermore, the ratio of terminal deoxynucleotidyl transferase (TdT)-positive lymphocytes was increased in components with higher expression of \u03b25t. These results indicate that the histological diversity of type AB thymoma correlates with expression of a functional marker \u03b25t and abundance of TdT-positive lymphocytes.<\/jats:p>","DOI":"10.1136\/jclinpath-2013-201930","type":"journal-article","created":{"date-parts":[[2013,11,29]],"date-time":"2013-11-29T20:26:29Z","timestamp":1385756789000},"page":"276-278","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Expression of thymoproteasome subunit \u03b25t in type AB thymoma"],"prefix":"10.1136","volume":"67","author":[{"given":"Yosuke","family":"Yamada","sequence":"first","affiliation":[{"name":"Department of Surgical Pathology, Hokkaido University Hospital, Sapporo, Japan"},{"name":"Department of Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Utano","family":"Tomaru","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Ishizu","sequence":"additional","affiliation":[{"name":"Health Sciences, Hokkaido University, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Kiuchi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Kasahara","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Matsuno","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology, Hokkaido University Hospital, Sapporo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2013,11,29]]},"reference":[{"key":"2025092610153302000_67.3.276.1","doi-asserted-by":"crossref","unstructured":"Rosai J . Histological typing of tumors of the thymus. Berlin: Springer-Verlag, 1999.","DOI":"10.1007\/978-3-642-60157-6"},{"key":"2025092610153302000_67.3.276.2","unstructured":"Muller-Hermelink HK Engel P Kuo TT . Tumors of the thymus. In: Travis WD Brambilla E Muller-Hermelink HK , eds. Pathology and Genetics, Tumours of the lung, pleura, thymus and heart. Lyon: IARC Press, 2004:146\u201374."},{"key":"2025092610153302000_67.3.276.3","doi-asserted-by":"publisher","DOI":"10.1309\/CAV8RNU5TKNACKNC"},{"key":"2025092610153302000_67.3.276.4","doi-asserted-by":"publisher","DOI":"10.1097\/00001622-200009000-00007"},{"key":"2025092610153302000_67.3.276.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64426-4"},{"key":"2025092610153302000_67.3.276.6","doi-asserted-by":"publisher","DOI":"10.1126\/science.1141915"},{"key":"2025092610153302000_67.3.276.7","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-11-187633"},{"key":"2025092610153302000_67.3.276.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2008.03.002"},{"key":"2025092610153302000_67.3.276.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.10.009"},{"key":"2025092610153302000_67.3.276.10","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-013-0234-1"},{"key":"2025092610153302000_67.3.276.11","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182237f5d"},{"key":"2025092610153302000_67.3.276.12","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.172"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jclinpath-2013-201930","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:15:38Z","timestamp":1758906938000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jclinpath-2013-201930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,29]]},"references-count":12,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,2,14]]},"published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1136\/jclinpath-2013-201930"],"URL":"https:\/\/doi.org\/10.1136\/jclinpath-2013-201930","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,29]]}}}