{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T18:32:06Z","timestamp":1763749926267,"version":"3.45.0"},"reference-count":21,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2014,3,18]]},"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The diagnosis of primary myelofibrosis (PMF) strongly relies on the bone marrow biopsy findings, but a report model has not been standardised. Our aim was to establish general recommendations for bone marrow evaluation and standardised reporting in a case suspicious of PMF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Delphi method was employed to obtain expert consensus. An advisory panel of 10 leading members identifies a total of 37 haematopathology experts to participate. The first Delphi round included a questionnaire with three main groups of items: minimal clinical and laboratory data considered necessary before reporting, minimal descriptive aspects to record and main histological differential diagnosis. The final report content was based on consensus obtained after the second Delphi round.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The minimal data considered necessary were age, splenomegaly, haemoglobin, leucocyte and platelet counts, differential blood cell count, leucoerythroblastic blood picture, lactate dehydrogenase (LDH) level,\n                      <jats:italic>BCR-ABL<\/jats:italic>\n                      and\n                      <jats:italic>JAK2<\/jats:italic>\n                      mutational status, reticulin stain and the internal control for the reticulin staining. The minimal descriptive aspects to report were cellularity, osteosclerosis, megakaryocytic morphology and localisation, dense megakaryocytic clusters, quantity of granulocytic precursors, grade of myelofibrosis in a scale of 4, and a proposed final diagnostic approach. The entities to be considered for differential diagnosis were mainly the other classical chronic myeloproliferative neoplasms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The Delphi method is a robust tool to determine essential information to be included in a pathology report. A standardised good-quality histopathological report form may help to homogenise PMF diagnosis. A close collaboration between the pathologist and the haematologist is desirable according to our survey.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jclinpath-2014-202246","type":"journal-article","created":{"date-parts":[[2014,4,7]],"date-time":"2014-04-07T23:11:32Z","timestamp":1396912292000},"page":"620-625","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Pathology reporting of bone marrow biopsy in myelofibrosis; application of the Delphi consensus process to the development of a standardised diagnostic report"],"prefix":"10.1136","volume":"67","author":[{"given":"Jos\u00e9 M","family":"Raya","sequence":"first","affiliation":[{"name":"Department of Hematopathology, Hospital Universitario de Canarias, Tenerife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"Montes-Moreno","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Universitario Marqu\u00e9s de Valdecilla, Santander, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agust\u00edn","family":"Acevedo","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Universitario Quir\u00f3n, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Ferr\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Cl\u00ednico de Valencia, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1ximo","family":"Fraga","sequence":"additional","affiliation":[{"name":"Department of Pathology, Facultad de Medicina and Hospital Cl\u00ednico Universitario de Santiago de Compostela, Santiago de Compostela, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan F","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Pathology, MD Anderson Cancer Center, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital del Mar, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Empar","family":"Mayordomo-Aranda","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital de La Fe, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Men\u00e1rguez","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Besses","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hospital del Mar, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reyes","family":"Calzada","sequence":"additional","affiliation":[{"name":"Department of Novartis Oncology, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Rozman","sequence":"additional","affiliation":[{"name":"Hematopathology Unit, Pathology Department, Hospital Cl\u00ednic, IDIBAPS, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2014,4,7]]},"reference":[{"key":"2025112110282799000_67.7.620.1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-04-083501"},{"key":"2025112110282799000_67.7.620.2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.34.5298"},{"key":"2025112110282799000_67.7.620.3","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.047811"},{"key":"2025112110282799000_67.7.620.4","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.047811"},{"key":"2025112110282799000_67.7.620.5","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181ce1447"},{"key":"2025112110282799000_67.7.620.6","first-page":"9","article-title":"The Delphi method and the investigation in health services","volume":"14","author":"Gallardo","year":"2008","journal-title":"Ciencia y 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Reproducibility of the WHO histological criteria for the diagnosis of Philadelphia chromosome-negative myeloproliferative neoplasms. Mod Pathol 2013. doi: 10.1038\/modpathol.2013.196. 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