{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:12:46Z","timestamp":1791339166938,"version":"4.3.1"},"reference-count":54,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2014,4,12]]},"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:p>The <jats:italic>BECN1<\/jats:italic> gene encodes the Beclin-1 protein, which is a well-established regulator of the autophagic pathway. It is a mammalian orthologue of the <jats:italic>ATG6<\/jats:italic> gene in yeast and was one of the first identified mammalian autophagy-associated genes. Beclin-1 interacts with a number of binding partners in the cell which can lead to either activation (eg, via PI3KC3\/Vps34, Ambra 1, UV radiation resistance-associated gene) or inhibition (eg, via Bcl-2, Rubicon) of the autophagic pathway. Apart from its role as a regulator of autophagy, it is also shown to effect important biological processes in the cell such as apoptosis and embryogenesis. Beclin-1 has also been implicated to play a critical role in the pathology of a variety of disease states including cancer, neurological disorders (eg, Alzheimer's disease, Parkinson's disease) and viral infections. Thus, understanding the functions of Beclin-1 and its interactions with other cellular components will aid in its development as an important therapeutic target for future drug development.<\/jats:p>","DOI":"10.1136\/jclinpath-2014-202356","type":"journal-article","created":{"date-parts":[[2014,5,9]],"date-time":"2014-05-09T01:57:33Z","timestamp":1399600653000},"page":"656-660","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":55,"title":["Gene of the month: <i>BECN1<\/i>"],"prefix":"10.1136","volume":"67","author":[{"given":"Sumit","family":"Sahni","sequence":"first","affiliation":[{"name":"Molecular Pharmacology and Pathology Program, Department of Pathology, Bosch Institute, Blackburn Building (D06), University of Sydney, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelica M","family":"Merlot","sequence":"additional","affiliation":[{"name":"Molecular Pharmacology and 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