{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:48:24Z","timestamp":1790214504663,"version":"4.1.0"},"reference-count":19,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2014,8,15]]},"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To perform a pharmaco-economic analysis of prescribing alternative antibiotics in patients with a diagnostic label of \u2018penicillin allergy\u2019 and assess whether collation of information from a structured history and liaison with the family physician could reduce costs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective pro-forma-based interview of randomly selected in-patients and their family physician was used to assess the validity of the diagnostic label of \u2018penicillin allergy\u2019. Cost analysis of prescription of alternative antibiotics was performed and compared with first-line agents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>102 patients were assessed and only 40% (n=41) were found to have a history consistent with penicillin hypersensitivity, 40% (n=41) were likely \u2018not allergic\u2019 and 20% (n=20) had \u2018indeterminate\u2019 reactions. Total cost of antibiotics prescribed for patients with penicillin allergy was 1.82\u20132.58-fold higher than for first-line antibiotics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Obtaining a structured history from the patient and family physician alone can enable an accurate identification of penicillin allergy status. Total acquisition cost of second-line antibiotics is higher than if these patients were prescribed first-line antibiotics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jclinpath-2014-202438","type":"journal-article","created":{"date-parts":[[2014,9,3]],"date-time":"2014-09-03T09:21:38Z","timestamp":1409736098000},"page":"1088-1092","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":97,"title":["A real-time prospective evaluation of clinical pharmaco-economic impact of diagnostic label of \u2018penicillin allergy\u2019 in a UK teaching hospital"],"prefix":"10.1136","volume":"67","author":[{"given":"M","family":"Li","sequence":"first","affiliation":[{"name":"Department of Microbiology, Birmingham Heartlands Hospital, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M T","family":"Krishna","sequence":"additional","affiliation":[{"name":"Department of Allergy and Immunology, Birmingham 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