{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:49:08Z","timestamp":1763747348119,"version":"3.44.0"},"reference-count":15,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2014,9,24]]},"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:p>\n                  <jats:italic>KRAS<\/jats:italic> mutation status predicts response to anti-EGFR therapy in colorectal cancer patients. Here we report an interesting case of discordant <jats:italic>KRAS<\/jats:italic> mutation status in a patient with two separate tumour foci. Tumour A in sigmoid colon invaded through muscularis propria into the subserosal fat with metastatic disease in regional lymph nodes (pT3N2b). Tumour B in ascending colon had a relatively lower stage and no metastasis (pT2N0). Both tumours showed similar morphology, immunohistochemical staining and microsatellite instability pattern. <jats:italic>KRAS<\/jats:italic> mutation, however, was detected only in tumour A. These findings indicate distinct clonal nature of these two tumours. The discordance of <jats:italic>KRAS<\/jats:italic> mutation status also suggests that a combination of anti-epidermal growth factor receptor and chemotherapy is likely the best treatment option for this patient. This case exemplifies a notion that comprehensive pathological work-up comprising molecular testing is critical to guide the diagnosis and treatment decisions for colorectal cancer patients with multiple tumours.<\/jats:p>","DOI":"10.1136\/jclinpath-2014-202591","type":"journal-article","created":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T01:13:03Z","timestamp":1413249183000},"page":"83-85","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["<i>KRAS<\/i> mutation status impacts diagnosis and treatment decision in a patient with two colon tumours: a case report"],"prefix":"10.1136","volume":"68","author":[{"given":"Xiaodong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, USC\/LAC Medical Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Pezeshkpour","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, USC\/LAC Medical Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA"},{"name":"Department of Pathology and Laboratory Medicine, VA Greater Los Angeles Healthcare System, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan T","family":"Phan","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, USC\/LAC Medical Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA"},{"name":"Department of Pathology and Laboratory Medicine, VA Greater Los Angeles Healthcare System, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2014,10,13]]},"reference":[{"key":"2025092504153660000_68.1.83.1","first-page":"425787","article-title":"Public Awareness of Colorectal Cancer Screening: Knowledge, Attitudes, and Interventions for Increasing Screening Uptake","volume":"2014","author":"Gimeno-Garcia","year":"2014","journal-title":"ISRN Oncol"},{"doi-asserted-by":"publisher","key":"2025092504153660000_68.1.83.2","DOI":"10.1200\/JCO.2011.40.4194"},{"doi-asserted-by":"publisher","key":"2025092504153660000_68.1.83.3","DOI":"10.1056\/NEJMoa1305275"},{"doi-asserted-by":"publisher","key":"2025092504153660000_68.1.83.4","DOI":"10.1056\/NEJMoa0804385"},{"doi-asserted-by":"publisher","key":"2025092504153660000_68.1.83.5","DOI":"10.1177\/1756283X13491797"},{"doi-asserted-by":"publisher","key":"2025092504153660000_68.1.83.6","DOI":"10.1016\/S0305-7372(10)70021-9"},{"doi-asserted-by":"publisher","key":"2025092504153660000_68.1.83.7","DOI":"10.1309\/AJCP7FO2VAXIVSTP"},{"unstructured":"\"Therascreen KRAS RGQ PCR Kit\u2014P110030\". Device Approvals and Clearances. 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