{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T17:02:36Z","timestamp":1765040556028,"version":"3.44.0"},"reference-count":14,"publisher":"BMJ","issue":"4","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2014,12,17]]},"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Specialist Integrated Haematological Malignancy Diagnostic Services (SIHMDS) were introduced as a standard of care within the UK National Health Service to reduce diagnostic error and improve clinical outcomes. Two broad models of service delivery have become established: \u2018co-located\u2019 services operating from a single-site and \u2018networked\u2019 services, with geographically separated laboratories linked by common management and information systems. Detailed systematic cost analysis has never been published on any established SIHMDS model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We used Activity Based Costing (ABC) to construct a cost model for our regional \u2018networked\u2019 SIHMDS covering a two-million population based on activity in 2011.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Overall estimated annual running costs were \u00a31\u2005056\u2005260 per annum (\u00a3733\u2005400 excluding consultant costs), with individual running costs for diagnosis, staging, disease monitoring and end of treatment assessment components of \u00a3723\u2005138, \u00a355\u2005302, \u00a3184\u2005152 and \u00a394\u2005134 per annum, respectively. The cost distribution by department was 28.5% for haematology, 29.5% for histopathology and 42% for genetics laboratories. Costs of the diagnostic pathways varied considerably; pathways for myelodysplastic syndromes and lymphoma were the most expensive and the pathways for essential thrombocythaemia and polycythaemia vera being the least.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>ABC analysis enables estimation of running costs of a SIHMDS model comprised of \u2018networked\u2019 laboratories. Similar cost analyses for other SIHMDS models covering varying populations are warranted to optimise quality and cost-effectiveness in delivery of modern haemato-oncology diagnostic services in the UK as well as internationally.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/jclinpath-2014-202624","type":"journal-article","created":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T23:38:59Z","timestamp":1422488339000},"page":"292-300","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Specialist integrated haematological malignancy diagnostic services: an Activity Based Cost (ABC) analysis of a networked laboratory service model"],"prefix":"10.1136","volume":"68","author":[{"given":"C","family":"Dalley","sequence":"first","affiliation":[{"name":"Departments of Haematology and Histopathology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Basarir","sequence":"additional","affiliation":[{"name":"School of Health and Related Research (ScHARR), University of Sheffield, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J G","family":"Wright","sequence":"additional","affiliation":[{"name":"Departments of Haematology and Histopathology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Fernando","sequence":"additional","affiliation":[{"name":"Departments of Haematology and Histopathology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Pearson","sequence":"additional","affiliation":[{"name":"Departments of Haematology and Histopathology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S E","family":"Ward","sequence":"additional","affiliation":[{"name":"School of Health and Related Research (ScHARR), University of Sheffield, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Thokula","sequence":"additional","affiliation":[{"name":"School of Health and Related Research (ScHARR), University of Sheffield, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Krishnankutty","sequence":"additional","affiliation":[{"name":"School of Health and Related Research (ScHARR), University of Sheffield, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Wilson","sequence":"additional","affiliation":[{"name":"Sheffield Diagnostic Genetics Service, Sheffield Children's NHS Foundation Trust, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Dalton","sequence":"additional","affiliation":[{"name":"Sheffield Diagnostic Genetics Service, Sheffield Children's NHS Foundation Trust, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Talley","sequence":"additional","affiliation":[{"name":"Sheffield Diagnostic Genetics Service, Sheffield Children's NHS Foundation Trust, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Barnett","sequence":"additional","affiliation":[{"name":"Departments of Haematology and Histopathology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Hughes","sequence":"additional","affiliation":[{"name":"Departments of Haematology and Histopathology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N R","family":"Porter","sequence":"additional","affiliation":[{"name":"Departments of Haematology and Histopathology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J T","family":"Reilly","sequence":"additional","affiliation":[{"name":"Departments of Haematology and Histopathology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J A","family":"Snowden","sequence":"additional","affiliation":[{"name":"Departments of Haematology and Histopathology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2015,1,28]]},"reference":[{"key":"2025092503575803000_68.4.292.1","unstructured":"Guidance for Commissioning Cancer Services. Improving Outcomes in Haematological Cancers: the manual. London, UK: National Institute for Clinical Excellence, 2003."},{"key":"2025092503575803000_68.4.292.2","unstructured":"National Peer Review Programme: Manual for Cancer Services Haemato-Oncology Cancer Measures (Version 1.1) April 2013."},{"key":"2025092503575803000_68.4.292.3","doi-asserted-by":"publisher","DOI":"10.1046\/j.0141-9854.2003.00559.x"},{"key":"2025092503575803000_68.4.292.4","unstructured":"Guidance for Commissioning Cancer Services. Improving Outcomes in Haematological Cancers: the research evidence. 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Trends in incidence and outcome for haematological cancers in England: 2001\u20132010. Public Health England, 2014."}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jclinpath-2014-202624","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T10:58:06Z","timestamp":1758797886000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jclinpath-2014-202624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,28]]},"references-count":14,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,3,17]]},"published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1136\/jclinpath-2014-202624"],"URL":"https:\/\/doi.org\/10.1136\/jclinpath-2014-202624","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[2015,1,28]]}}}