{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:08:25Z","timestamp":1791216505850,"version":"4.1.0"},"reference-count":17,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Cryptogenic organising pneumonia (COP) and acute fibrinous and organising pneumonia (AFOP) are recognised patterns of organising pneumonia (OP), a condition that resembles pneumonia but is not caused by infection. We have recognised granulomatous organising pneumonia (GOP) to be a similar histopathological entity where non-necrotising granulomata are intimately associated with the organising connective tissue. To what degree COP, AFOP and GOP represent distinct clinical and pathological disorders is unknown. This cross-sectional study sought to compare the pathological, clinical, and radiographical features of these OP patterns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Surgical lung biopsy specimens were reviewed for consecutive patients referred with OP to a metropolitan cancer centre. Clinical information and CT images were acquired from the hospital electronic medical record to determine the clinical and CT characteristics of each OP pattern.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty-one patients (35 men, 26 women), mean age 61.5\u2005years (range 8\u201385\u2005years), were available for analysis. Of these, 43 patients (70%) had at least one prior cancer; 27 (44%) had received chemotherapy and 18 (30%) had received radiation. Approximately, half (32 patients) had respiratory symptoms, most commonly cough, dyspnoea and\/or wheezing. While symptoms and mortality rates were not different among OP groups, AFOP patients more commonly had fever (p=0.04). GOP patients less commonly had received chemotherapy (p=0.03) and were more likely to present as masses\/nodules (p=0.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>AFOP and GOP, a newly described OP form, possess clinical and pathological findings that set it apart from a COP, suggesting an emerging spectrum of OP.<\/jats:p><\/jats:sec>","DOI":"10.1136\/jclinpath-2014-202626","type":"journal-article","created":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T03:12:53Z","timestamp":1425611573000},"page":"441-447","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":49,"title":["A comparison of the pathological, clinical and radiographical, features of cryptogenic organising pneumonia, acute fibrinous and organising pneumonia and granulomatous organising pneumonia"],"prefix":"10.1136","volume":"68","author":[{"given":"Marc B","family":"Feinstein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpa A","family":"DeSouza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre L","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane E","family":"Stover","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert T","family":"Heelan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tun\u00e7 A","family":"Iyriboz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Taur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D","family":"Travis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2015,3,5]]},"reference":[{"key":"2020081105500966000_68.6.441.1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201308-1483ST"},{"key":"2020081105500966000_68.6.441.2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198606000-00002"},{"key":"2020081105500966000_68.6.441.3","doi-asserted-by":"crossref","unstructured":"Travis WD , Colby TV , Koss MN , et al . Non-neoplastic disorders of the lower respiratory tract. 2nd edn. Washington DC: Armed Forces Institute of Pathology, 2002.","DOI":"10.55418\/1881041794"},{"key":"2020081105500966000_68.6.441.4","doi-asserted-by":"publisher","DOI":"10.1159\/000103240"},{"key":"2020081105500966000_68.6.441.5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198501173120304"},{"issue":"(1 Suppl)","key":"2020081105500966000_68.6.441.6","doi-asserted-by":"crossref","first-page":"8S","DOI":"10.1378\/chest.102.1.8S","article-title":"Cryptogenic organizing pneumonitis. 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