{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T09:23:25Z","timestamp":1759742605905,"version":"3.44.0"},"reference-count":13,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2015,2,4]]},"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:p>Cytokeratin 7 (CK 7) negative breast tumours are reported to occur rarely. We studied 14 CK 7 negative cases of primary invasive ductal carcinoma (IDC) detected during sentinel lymph node metastases work-up and immunohistochemistry panel in the work-up of metastatic carcinoma of unknown origin. Axillary lymph node metastases were present in seven patients (50%). Oestrogen receptor (ER) was strongly positive in all cases: progesterone receptor in 78%, Her-2\/neu in 7% and high proliferation index with Ki-67 &gt;20% was seen in 71% of the cases.<\/jats:p>\n               <jats:p>Metastatic and\/or recurrence were found in 8 of 14 patients (57%) with the mean clinical follow-up of 55\u2005months. Metastatic sites include multiple bones, brain, spinal cord, liver, pancreas, ovary, lung, lymph node other than ipsilateral axillary and skin. 12 of 14 patients received adjuvant chemotherapy. All 14 patients received hormonal therapy and radiation therapy. Morphologically, IDC with neuroendocrine features was noted in 57%. Synaptophysin stain was positive in 57% and chromogranin was positive in 21% of the cases. In conclusion, these CK 7 negative breast carcinomas were ER positive, mostly Her-2\/neu negative, had high Ki-67 and frequently showed neuroendocrine differentiation. More than half of these cases had a poor outcome.<\/jats:p>","DOI":"10.1136\/jclinpath-2014-202729","type":"journal-article","created":{"date-parts":[[2015,2,26]],"date-time":"2015-02-26T03:18:03Z","timestamp":1424920683000},"page":"484-487","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Cytokeratin 7 negative invasive breast carcinoma: clinicopathological and immunohistochemical analysis of 14 cases with clinical follow-up"],"prefix":"10.1136","volume":"68","author":[{"given":"Neda A","family":"Moatamed","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annie","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaled","family":"Sarah","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia K","family":"Apple","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2015,2,20]]},"reference":[{"key":"2025092510295740000_68.6.484.1","doi-asserted-by":"publisher","DOI":"10.1007\/s004280050226"},{"key":"2025092510295740000_68.6.484.2","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1524-4741.2012.01279.x","article-title":"Inference of the basal epithelial phenotype in breast carcinoma from differential maker expression, using tissue microarrays in triple negative breast cancer and women younger than 35","volume":"5","author":"Nassar","year":"2012","journal-title":"Breast J"},{"key":"2025092510295740000_68.6.484.3","unstructured":"Lakhani S , Ellis I , Schnitt S , et al . WHO classification of tumours of the breast. Lyon, France: IARC Press, 2012."},{"key":"2025092510295740000_68.6.484.4","doi-asserted-by":"publisher","DOI":"10.1016\/S1092-9134(99)80013-6"},{"key":"2025092510295740000_68.6.484.5","unstructured":"Ellis P , Schnitt SJ , Sastre-Garau X , et al . Tumors of the breast and female genital organ: pathology and genetics. Lyon, France: IARC Press, 2003."},{"key":"2025092510295740000_68.6.484.6","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-010-1229-9"},{"key":"2025092510295740000_68.6.484.7","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/BF00197547","article-title":"Carcinomas of the breast with endocrine differentiation: a review","volume":"425","author":"Maluf","year":"1994","journal-title":"Virchows Arch"},{"key":"2025092510295740000_68.6.484.8","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199206000-00004"},{"key":"2025092510295740000_68.6.484.9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2002.01336.x"},{"key":"2025092510295740000_68.6.484.10","doi-asserted-by":"crossref","first-page":"S115","DOI":"10.1093\/annonc\/12.suppl_2.S115","article-title":"Clinical significance of neuroendocrine carcinoma of the breast","volume":"2","author":"Sapino","year":"2001","journal-title":"Ann Oncol"},{"key":"2025092510295740000_68.6.484.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2003.11.008"},{"key":"2025092510295740000_68.6.484.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2010.11.014"},{"key":"2025092510295740000_68.6.484.13","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25352"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jclinpath-2014-202729","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T17:30:11Z","timestamp":1758821411000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jclinpath-2014-202729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,20]]},"references-count":13,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2015,5,18]]},"published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1136\/jclinpath-2014-202729"],"URL":"https:\/\/doi.org\/10.1136\/jclinpath-2014-202729","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"type":"print","value":"0021-9746"},{"type":"electronic","value":"1472-4146"}],"subject":[],"published":{"date-parts":[[2015,2,20]]}}}