{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T22:48:29Z","timestamp":1773096509369,"version":"3.50.1"},"reference-count":30,"publisher":"BMJ","issue":"10","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2015,5,24]]},"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim of this study was to characterise plasma cell infiltrates, in terms of IgG4 positivity, in specific and non-specific plasma cell-rich chronic inflammatory conditions of the oral mucosa. Exploring the possibility that specific plasma cell-rich oral inflammatory conditions have association with or represent an oral manifestation of immunoglobulin G4-related disease (IgG4-RD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ten patients with plasma cell-rich chronic inflammatory conditions of the oral mucosa were identified (seven\u2014plasma cell mucositis and three\u2014non-specific diffuse oral mucosal inflammation with ulceration). For each patient, the clinical record and H&amp;E-stained sections were reviewed. Immunohistochemistry for IgG and IgG4 antibodies was performed on sections from the corresponding paraffin block, permitting calculation of the mean number of IgG4+ plasma cells per high-power field (HPF) and the IgG4+\/IgG+ plasma cell ratio.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In all the cases, only one histological hallmark of IgG4-RD\u2014a dense lymphoplasmacytic infiltrate\u2014was seen. Review of the medical histories did not reveal any features representing other manifestations of IgG4-RD. The number of IgG4+ plasma cells exceeded 100 per HPF in half of the cases. Only two cases had an IgG4+\/IgG+ plasma cell ratio of &gt;40%; both of which were in the non-specific oral inflammatory group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study suggests that plasma cell mucositis does not meet microscopic criteria for IgG4-RD. It importantly reinforces the opinion that IgG4+ plasma cells are major components of chronic inflammation in the oral cavity and the pertinence of correct contextual interpretation of histopathological features with clinical findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jclinpath-2014-202814","type":"journal-article","created":{"date-parts":[[2015,6,8]],"date-time":"2015-06-08T22:46:51Z","timestamp":1433803611000},"page":"802-807","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Are plasma cell-rich inflammatory conditions of the oral mucosa manifestations of IgG4-related disease?"],"prefix":"10.1136","volume":"68","author":[{"given":"Hannah","family":"Cottom","sequence":"first","affiliation":[{"name":"Department of Histopathology, Leeds Teaching Hospitals NHS Trust, Leeds, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan 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