{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:10:31Z","timestamp":1789513831335,"version":"build-2803163510"},"reference-count":72,"publisher":"BMJ","issue":"12","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2015,1,18]]},"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p>\n                    The diagnosis of panniculitis is a relatively rare occurrence for many practising pathologists. The smaller subset of lymphocyte-predominant panniculitis is further complicated by the diagnostic consideration of T cell lymphoma involving the subcutaneous tissue, mimicking inflammatory causes of panniculitis. Accurate classification of the panniculitis is crucial to direct clinical management as treatment options may vary from non-medical therapy to immunosuppressive agents to aggressive chemotherapy. Many diseases show significant overlap in clinical and histological features, making the process of determining a specific diagnosis very challenging. However, with an adequate biopsy including skin and deep subcutaneous tissue, a collaborative effort between clinician and pathologist can often lead to a specific diagnosis. This review provides an algorithmic approach to the diagnosis of lymphocyte-predominant panniculitis, including entities of septal-predominant pattern panniculitis (erythema nodosum, deep necrobiosis lipoidica, morphea profunda and sclerosing panniculitis) and lobular-predominant pattern panniculitis (lupus erythematous panniculitis\/lupus profundus, subcutaneous panniculitis-like T cell lymphoma, cutaneous \u03b3-\u03b4 T cell lymphoma,\n                    <jats:italic>Borrelia<\/jats:italic>\n                    infection and cold panniculitis).\n                  <\/jats:p>","DOI":"10.1136\/jclinpath-2014-202849","type":"journal-article","created":{"date-parts":[[2015,11,24]],"date-time":"2015-11-24T00:52:40Z","timestamp":1448326360000},"page":"954-962","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Lymphocytic panniculitis: an algorithmic approach to lymphocytes in subcutaneous tissue"],"prefix":"10.1136","volume":"68","author":[{"given":"Carolyn J","family":"Shiau","sequence":"first","affiliation":[{"name":"Department of Pathology, Royal Columbian Hospital, New Westminster, British Columbia, Canada"},{"name":"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie S","family":"Abi Daoud","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Calgary and Calgary Laboratory Services, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se Mang","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard 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