{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T19:27:31Z","timestamp":1781810851541,"version":"3.54.5"},"reference-count":11,"publisher":"BMJ","issue":"7","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["J Clin Pathol"],"accepted":{"date-parts":[[2015,3,29]]},"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To assess the performance of a clinically validated human papillomavirus (HPV) test (the Cobas 4800 HPV test) in urine and self-taken vaginal specimens within a colposcopy population and to assess HPV prevalence before and after treatment across the different biospecimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 100 women attending a colposcopy clinic provided three biospecimens (a clinician-taken liquid-based cytology sample (LBC), a self-taken vaginal sample and a urine sample) for HPV testing. HPV prevalence and concordance was compared across the biospecimens and clinical performance relative to the detection of cervical intraepithelial neoplasia (CIN)2+ and CIN3+ was assessed. A total of 39 women retuned at 6\u2005months for a post-treatment follow-up appointment, and HPV concordance in all biospecimens was measured relative to their original HPV status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>65 cases of CIN2+ were detected in the baseline population; sensitivity for CIN2+ was 92% (82 to 97) for the vaginal and the LBC sample and 80.0 (68% to 88%) for the urine sample. In the follow-up (post treatment) population, women were twice as likely to be HPV positive in their urine or vaginal sample compared with the equivalent LBC sample.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Vaginal and LBC samples showed very similar performance for the detection of CIN2+ in this population using the Cobas HPV test; further validation of these findings in screening contexts will be of value. Self-taken samples may have less utility in a \u2018test of cure\u2019 setting\u2014given the higher prevalence of HPV relative to LBC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/jclinpath-2014-202851","type":"journal-article","created":{"date-parts":[[2015,4,15]],"date-time":"2015-04-15T23:26:24Z","timestamp":1429140384000},"page":"567-570","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":33,"title":["Cobas 4800 HPV detection in the cervical, vaginal and urine samples of women with high-grade CIN before and after treatment"],"prefix":"10.1136","volume":"68","author":[{"given":"Grazyna A","family":"Stanczuk","sequence":"first","affiliation":[{"name":"Department of Research and Development, Dumfries and Galloway Royal Infirmary, Dumfries, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Currie","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Dumfries and Galloway Royal Infirmary, Dumfries, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwen","family":"Baxter","sequence":"additional","affiliation":[{"name":"Department of Research and Development, Dumfries and Galloway Royal Infirmary, Dumfries, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adele","family":"Foster","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Dumfries and Galloway Royal Infirmary, Dumfries, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Gibson","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Dumfries and Galloway Royal Infirmary, Dumfries, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catriona","family":"Graham","sequence":"additional","affiliation":[{"name":"Wellcome Trust Clinical Research Facility, University of Edinburgh, Western General Hospital, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Cuschieri","sequence":"additional","affiliation":[{"name":"Scottish HPV Reference Laboratory, Royal Infirmary of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2015,4,15]]},"reference":[{"key":"2025112108363949000_68.7.567.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.06.095"},{"key":"2025112108363949000_68.7.567.2","doi-asserted-by":"publisher","DOI":"10.1586\/14737159.2014.893829"},{"key":"2025112108363949000_68.7.567.3","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21139"},{"key":"2025112108363949000_68.7.567.4","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2013.869618"},{"key":"2025112108363949000_68.7.567.5","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27790"},{"key":"2025112108363949000_68.7.567.6","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70570-9"},{"key":"2025112108363949000_68.7.567.7","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g5264"},{"key":"2025112108363949000_68.7.567.8","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.30"},{"key":"2025112108363949000_68.7.567.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61947-9"},{"key":"2025112108363949000_68.7.567.10","unstructured":"Quest for improved, women friendly cervical screening continued: Evaluation of HPV DNA testing in primary cervical screening. An operational study in Dumfries and Galloway\u2014(12\/WS\/0085)."},{"key":"2025112108363949000_68.7.567.11","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2013-202014"}],"container-title":["Journal of Clinical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/jclinpath-2014-202851","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T16:36:49Z","timestamp":1763743009000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcp.bmj.com\/lookup\/doi\/10.1136\/jclinpath-2014-202851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,15]]},"references-count":11,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2015,6,19]]},"published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1136\/jclinpath-2014-202851"],"URL":"https:\/\/doi.org\/10.1136\/jclinpath-2014-202851","relation":{},"ISSN":["0021-9746","1472-4146"],"issn-type":[{"value":"0021-9746","type":"print"},{"value":"1472-4146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,15]]}}}